Day: February 22, 2023

Serotonin syndrome associated with metaxalone overdose. was written by Bosak, Adam R;Skolnik, Aaron B. And the article was included in Journal of medical toxicology in 2014.Safety of 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one This article mentions the following:

INTRODUCTION: Serotonin syndrome is a potentially life-threatening entity associated with pro-serotonergic medications in therapeutic use, in overdose, or when co-administered with other drugs. A broad range of drugs and drug combinations have been associated with serotonin syndrome. Metaxalone overdose associated with serotonin syndrome has not been previously reported. CASE REPORT: (Case 1) A 23-year-old female overdosed on tramadol and metaxalone. She developed dysautonomia, diaphoresis, lower extremity rigidity and spontaneous clonus, flaccid upper extremities, and hyperthermia 5 h after ingestion. Her course was complicated by status epilepticus. (Case 2) A 56-year-old female overdosed on metaxalone and was found unresponsive. She developed dysautonomia, lower extremity rigidity and spontaneous clonus, flaccid upper extremities, rhabdomyolysis, acute renal failure, and hyperthermia. Non-depolarizing neuromuscular blockade and cooling blankets were required to control hyperthermia in both cases. Serum metaxalone levels were markedly elevated in both cases. CONCLUSION: These are the first reported cases of metaxalone overdose associated with serotonin syndrome, which may be related to monoamine oxidase inhibition. In the experiment, the researchers used many compounds, for example, 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1Safety of 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one).

5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1) belongs to oxazolidine derivatives. Oxazolidine-based compounds are well-known chiral auxiliaries and strategic molecular moieties in chemistry since they can effectively mask or mimic amino acid units or amino alcohols. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Safety of 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Synthesis of a Common Cyclopentanoid Building Block for the Total Synthesis of Jatropha-5,12- and -6(17),11-dienes by Uncatalyzed Intramolecular Carbonyl Ene (ICE) Reaction was written by Butt, Lena;Hiersemann, Martin. And the article was included in Synthesis in 2014.SDS of cas: 89028-40-0 This article mentions the following:

The authors report a scalable synthesis of a common cyclopentanoid building block for 15-hydroxyjatropha-5,12-diene and 15-hydroxyjatropha-6(17),11-diene in eleven steps. A key to the synthesis is an uncatalyzed intramol. carbonyl-ene (ICE) reaction of an ε,ζ-unsaturated α-keto ester. The synthesis of the target compound was achieved using (4R)-4-(1-methylethyl)-3-(1-oxopropyl)-2-oxazolidinone as a chiral auxiliary. The title compound thus formed was a cyclopentanoid intermediate for 3a-(acetyloxy)-1-(benzoyloxy)-2,3,3a,7,8,10,11,13a-octahydro-7,11-dihydroxy-2,5,8,8,12-pentamethyl-1H-cyclopentacyclododecene-4,9-dione [euphoheliosnoid D]. In the experiment, the researchers used many compounds, for example, (R)-4-Isopropyl-3-propionyloxazolidin-2-one (cas: 89028-40-0SDS of cas: 89028-40-0).

(R)-4-Isopropyl-3-propionyloxazolidin-2-one (cas: 89028-40-0) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.SDS of cas: 89028-40-0

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Lithium Amino Alkoxide-Evans Enolate Mixed Aggregates: Aldol Addition with Matched and Mismatched Stereocontrol was written by Jermaks, Janis;Tallmadge, Evan H.;Keresztes, Ivan;Collum, David B.. And the article was included in Journal of the American Chemical Society in 2018.Computed Properties of C9H15NO3 This article mentions the following:

Building on structural and mechanistic studies of lithiated enolates derived from acylated oxazolidinones (Evans enolates) and chiral lithiated amino alkoxides, we found that amino alkoxides amplify the enantioselectivity of aldol additions The pairing of enantiomeric series affords matched and mismatched stereoselectivities. The structures of mixed tetramers showing 2:2 and 3:1 (alkoxide-rich) stoichiometries are determined spectroscopically. Rate and computational studies provide a viable mechanistic and stereochem. model based on the direct reaction of the 3:1 mixed tetramers, but they raise unanswered questions for the 2:2 mixed aggregates. In the experiment, the researchers used many compounds, for example, (R)-4-Isopropyl-3-propionyloxazolidin-2-one (cas: 89028-40-0Computed Properties of C9H15NO3).

(R)-4-Isopropyl-3-propionyloxazolidin-2-one (cas: 89028-40-0) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Computed Properties of C9H15NO3

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Analysis on nutrition and volatile components of Shenxian (fairy) soybean product in north Anhui region was written by Wang, Wei;Zhang, Yong-jin;Jiang, Zhong-hui;Gu, Zheng-fen;Liu, Wei;Ye, Chuan;Lin, Lin;Jiang, Shao-tong;Lu, Jian-feng. And the article was included in Shipin Yu Fajiao Gongye in 2014.Recommanded Product: 20662-84-4 This article mentions the following:

Shenxian (fairy) bean is a traditional fermented soybean product especially popular in the north Anhui region. To study the nutrition and volatile components of Shenxian bean, the national standard method, head-space solid phase microextraction (HS-SPME) and GC-MS anal. were applied. The results indicated that the contents of basic nutrition components of Shenxian bean were very close to natto. A total of 72 compounds were identified and they were classified into nine major groups. Major classes of compounds included alcs. (16), nitrogenous (8), esters (2), aldehydes (14), hydrocarbons (18), ketones (4), acids (3), phenols (4) and ethers (3). Furthermore, total free amino acids (FAA) of Shenxian bean reached 4.70 mg/g with the highest glutamic acid concentration In conclusion, Shenxian soybean product has a good flavor and higher nutritive values. In the experiment, the researchers used many compounds, for example, 2,4,5-Trimethyloxazole (cas: 20662-84-4Recommanded Product: 20662-84-4).

2,4,5-Trimethyloxazole (cas: 20662-84-4) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Recommanded Product: 20662-84-4

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Liquid-liquid partition coefficients of β-diketonato complexes of chromium(III) and palladium(II) in dodecane/(water-methanol mixture) systems was written by Saitoh, Koichi;Tsukahara, Satoshi;Suzuki, Nobuo. And the article was included in Analytical Letters in 1988.Application In Synthesis of Bis(2,2′,6,6′-tetramethylheptanedionato) palladium(II) This article mentions the following:

Liquid-liquid partition coefficients (K_D) of both Cr(III) and Pd(II) complexes of several β-diketones between dodecane and a aqueous MeOH mixture were determined by a combined batch technique and high performance liquid chromatog. method. The K_D of each metal complex is enhanced as the MeOH content of the liquid mixture decreases. In both homologs of the Cr(III) complexes and the Pd(II) complexes, the K_D increases with an increase in mol. size of the complex, although the Cr(III) complex tends to have a smaller K_D than the Pd(II) complex whose mol. size is comparable with that of the Cr complex. In the experiment, the researchers used many compounds, for example, Bis(2,2′,6,6′-tetramethylheptanedionato) palladium(II) (cas: 15214-66-1Application In Synthesis of Bis(2,2′,6,6′-tetramethylheptanedionato) palladium(II)).

Bis(2,2′,6,6′-tetramethylheptanedionato) palladium(II) (cas: 15214-66-1) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Application In Synthesis of Bis(2,2′,6,6′-tetramethylheptanedionato) palladium(II)

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Fractionated stir bar sorptive extraction using conventional and solvent-assisted approaches for enhanced identification capabilities of aroma compounds in beverages was written by Ochiai, Nobuo;Sasamoto, Kikuo;Sasaki, Tetsuya;David, Frank;Sandra, Pat. And the article was included in Journal of Chromatography A in 2020.Related Products of 20662-84-4 This article mentions the following:

For successful profiling of aroma carriers in food samples, a highly efficient extraction method is mandatory. A two-step stir bar sorptive extraction (SBSE) approach, namely fractionated SBSE (Fr-SBSE), was developed to improve both the organoleptic and the chem. identification of aroma compounds in beverages. The first extraction consists of a conventional mSBSE using three polydimethylsiloxane (PDMS) stir bars (1stmSBSE). This is followed by a solvent-assisted mSBSE performed on the same sample using three solvent-swollen PDMS stir bars (2nd SA-mSBSE). The 1stmSBSE mainly extracts apolar/medium polar solutes with log Kow values >2, while the 2nd SA-mSBSE mainly extracts polar solutes with log Kow values <2. After this two-step fractionation procedure, either thermal desorption (TD) or liquid desorption – large volume injection (LD-LVI), followed by GC-MS is performed on each set of three stir bars. A real-life sample of roasted green tea was used for method development. The performance of the Fr-SBSE method is further illustrated with sensory evaluations and GC-MS anal. for a stout beer sample. Compared to an extraction procedure with SA-mSBSE only, Fr-SBSE including a 1stmSBSE and a 2nd SA-mSBSE reduced co-elution of aroma compounds in the chromatograms and was capable of providing improved mass spectral quality for identification of 17 addnl. compounds in roasted green tea, and 12 addnl. compounds in stout beer, resp. Moreover, odor description and characterization were clearly improved. In the experiment, the researchers used many compounds, for example, 2,4,5-Trimethyloxazole (cas: 20662-84-4Related Products of 20662-84-4).

2,4,5-Trimethyloxazole (cas: 20662-84-4) belongs to oxazolidine derivatives. Oxazolidine-based compounds are well-known chiral auxiliaries and strategic molecular moieties in chemistry since they can effectively mask or mimic amino acid units or amino alcohols. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.Related Products of 20662-84-4

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Alkylative Carboxylation of Ynamides and Allenamides with Functionalized Alkylzinc Halides and Carbon Dioxide by a Copper Catalyst was written by Takimoto, Masanori;Gholap, Sandeep Suryabhan;Hou, Zhaomin. And the article was included in Chemistry – A European Journal in 2019.Name: 3-(Phenylethynyl)oxazolidin-2-one This article mentions the following:

The alkylative carboxylation of ynamides and allenamides with CO₂ and alkylzinc halides catalyzed by a copper catalyst was developed. A variety of alkylzinc halides bearing functional groups were used for this transformation to afford α,β-unsaturated carboxylic acids, which contain the α,β-dehydroamino acid skeleton, introducing the corresponding alkyl group and CO₂ across the carbon-carbon triple or double bond. This alkylative carboxylation formally consists of Cu-catalyzed carbozincation of ynamides or allenamides with alkylzinc halides and the subsequent nucleophilic carboxylation of the resulting alkenylzinc species with CO₂. This protocol would be a useful method for the synthesis of α,β-dehydroamino acid derivatives possessing a functionalized alkyl group due to the high regio- and stereoselectivity, simple one-pot procedure as well as the use of CO₂ as a starting material. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Name: 3-(Phenylethynyl)oxazolidin-2-one).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Name: 3-(Phenylethynyl)oxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Rapid identification of volatile compounds in sesame oil by headspace gas chromatography-mass spectrometry with calibrated lineshape isotope profile search(CLIPs) was written by Ma, Yu-song;Wang, Jing;Ai, Lian-feng;Dou, Cai-yun;Jia, Hai-tao;Yu, Meng. And the article was included in Fenxi Ceshi Xuebao in 2015.Application of 20662-84-4 This article mentions the following:

The volatile compounds in sesame oil were analyzed by headspace gas chromatog.-mass spectrometry(GC-MS) with calibrated lineshape isotope profile search(CLIPs) function integrated in Mass Works^TM software. 71 Kinds of components including pyrazines, pyrroles, pyridines, thiazoles, thiophenes, indoles, oxazoles, furans, aldehydes and phenols etc., could be identified, which accounted for 90.2% of the total normalized peak areas. Among them, aldehydes, phenols, pyrazines and furans account for 37.4%, 20.1%, 10.0% and 6.7%, resp. They were principal contributors of sesame oil flavor components. The application of CLIPs can provide the accurate mol. weight of compounds and an important basis for the low-resolution quadrupole mass spectrometer to identify the elemental composition and the structure of compound The study provided a new tech. means for the component anal. of sesame oils. In the experiment, the researchers used many compounds, for example, 2,4,5-Trimethyloxazole (cas: 20662-84-4Application of 20662-84-4).

2,4,5-Trimethyloxazole (cas: 20662-84-4) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. In another report, the incorporation of an additional substituted oxazolidine ring over a range of new biphenylazepinium salt organocatalysts for the asymmetric epoxidation of alkenes improved enantiocontrol over the parent structures.Application of 20662-84-4

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Palladium-Catalyzed Oxygenative Cross-Coupling of Ynamides and Benzyl Bromides by Carbene Migratory Insertion was written by Gao, Yunpeng;Wu, Guojiao;Zhou, Qi;Wang, Jianbo. And the article was included in Angewandte Chemie, International Edition in 2018.Application of 888329-88-2 This article mentions the following:

A palladium-catalyzed oxygenative cross-coupling of ynamides and benzyl bromides has been developed. After subsequent hydrogenation, α,α-disubstituted amide derivatives, e. g., I, were obtained in good yields. Migratory insertion of α-oxo palladium carbene species, generated by intermol. oxidation, is proposed as the key step in this reaction. The study demonstrates the potential of ynamides to serve as carbene precursors in palladium-catalyzed C-C bond-forming cross-coupling reactions. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Application of 888329-88-2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.Application of 888329-88-2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Landfill leachate as a mirror of today’s disposable society: Pharmaceuticals and other contaminants of emerging concern in final leachate from landfills in the conterminous United States was written by Masoner, Jason R.;Kolpin, Dana W.;Furlong, Edward T.;Cozzarelli, Isabelle M.;Gray, James L.. And the article was included in Environmental Toxicology and Chemistry in 2016.Application of 1665-48-1 This article mentions the following:

Final leachates (leachate after storage or treatment processes) from 22 landfills in 12 states were analyzed for 190 pharmaceuticals and other contaminants of emerging concern (CECs), which were detected in every sample, with the number of CECs 1-58 (median =22). In total, 101 different CECs were detected in leachate samples, including 43 prescription drugs, 22 industrial chems., 15 household chems., 12 nonprescription drugs, 5 steroid hormones, and 4 animal/plant sterols. The most frequently detected CECs were lidocaine (91%, local anesthetic), cotinine (86%, nicotine degradate), carisoprodol (82%, muscle relaxant), bisphenol A (77%, component of plastics and thermal paper), carbamazepine (77%, anticonvulsant), and N,N-diethyltoluamide (68%, insect repellent). Concentrations of CECs spanned 7 orders of magnitude, ranging from 2.0 ng/L (estrone) to 17,200,000 ng/L (bisphenol A). Concentrations of household and industrial chems. were the greatest (∼1000-1,000,000 ng/L), followed by plant/animal sterols (∼1000-100,000 ng/L), nonprescription pharmaceuticals (∼100-10,000 ng/L), prescription pharmaceuticals (∼10-10,000 ng/L), and steroid hormones (∼10-100 ng/L). The CEC concentrations in leachate from active landfills were significantly greater than those in leachate from closed, unlined landfills (p =0.05). The CEC concentrations were significantly greater (p <0.01) in untreated leachate compared with treated leachate. The CEC concentrations were significantly greater in leachate disposed to wastewater treatment plants from modern lined landfills than in leachate released to groundwater from closed, unlined landfills (p =0.04). The CEC concentrations were significantly greater (p =0.06) in the fresh leachate (leachate before storage or treatment) reported in a previous study compared with the final leachate sampled for the present study. Environ Toxicol Chem 2015;9999:1-13, Published 2015 SETAC. This article is a US Government work and is in the public domain in the USA. In the experiment, the researchers used many compounds, for example, 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1Application of 1665-48-1).

5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Application of 1665-48-1

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem