Day: November 21, 2022

Zhuravleva, I. L. published the artcileSchemes for calculation of alkyloxazole and alkylthiazole retention indexes under capillary chromatography conditions, HPLC of Formula: 20662-83-3, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1990), 1338-44, database is CAplus.

Gas-chromatog. retention indexes were determined for the title compounds on 3 capillary columns, and the contributions of Me, Et, and Pr groups in different ring positions were calculated The results were used to predict retention indexes for di- and trisubstituted oxazoles and thiazoles.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C4H11NO, HPLC of Formula: 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Golovnya, R. V. published the artcileUse of the principle of nonadditivity of sorption energies for calculation of retention indexes of alkyloxazoles in capillary chromatography, HPLC of Formula: 20662-83-3, the publication is Zhurnal Analiticheskoi Khimii (1989), 44(11), 2037-42, database is CAplus.

Capillary GC retention indexes were converted to free energies of sorption (ΔG) of variously alkyl-substituted oxazoles. Nonadditive, i.e., portion-dependent alkyl substituent effects on ΔG were observed; thus Me-jump contribution to ΔG, ΔG^Me, increased in the order ΔG^Me(α_N) < ΔG^Me(α_N,O < ΔG^Me(α_O), with locals identified in structure I. Use of nonadditive ΔG^alkyl afforded predictions of GC retentions of alkyloxazoles in good agreement with experiment

Zhurnal Analiticheskoi Khimii published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, HPLC of Formula: 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Wang, T. H. published the artcileAnalysis of trace volatile organic compounds in coffee by headspace concentration and gas chromatography-mass spectrometry, HPLC of Formula: 20662-83-3, the publication is Chromatographia (1983), 17(8), 411-17, database is CAplus.

A exptl. method for the anal. of trace volatile organic compounds was developed and standardized. This new technique involves headspace sampling, heart cutting, collection, and concentration of the volatiles on a porous polymer (Tenax-GC), followed by sensory evaluation and 2-dimensional gas chromatog. with flame ionization and S-sensitive flame photometric detectors and He as carrier gas. Using the modified Purge and Trap Sampler for on-line anal., the loss of organic volatile compounds, which usually occurs during sample transfer, was prevented. A number of aroma-related organic volatile compounds in coffee have been separated and identified by this technique. The method was standardized for the general needs of other related areas of aroma research.

Chromatographia published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C7H13ClNNaO5S, HPLC of Formula: 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Messias Monteiro, Alex France published the artcileIn Silico Studies for Bacterystic Evaluation against Staphylococcus aureus of 2-Naphthoic Acid Analogues, Recommanded Product: (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one, the publication is Current Topics in Medicinal Chemistry (Sharjah, United Arab Emirates) (2020), 20(4), 293-304, database is CAplus and MEDLINE.

Staphylococcus aureus is a gram-pos. spherical bacterium commonly present in nasal fossae and in the skin of healthy people; however, in high quantities, it can lead to complications that compromise health. The pathologies involved include simple infections, such as folliculitis, acne, and delay in the process of wound healing, as well as serious infections in the CNS, meninges, lung, heart, and other areas. This research aims to propose a series of mols. derived from 2-naphthoic acid as a bioactive in the fight against S. aureus bacteria through in silico studies using mol. modeling tools. A virtual screening of analogs was done in consideration of the results that showed activity according to the prediction model performed in the KNIME Analytics Platform 3.6, violations of the Lipinski rule, absorption rate, cytotoxicity risks, energy of binder-receptor interaction through mol. docking, and the stability of the best profile ligands in the active site of the proteins used (PDB ID 4DXD and 4WVG). Seven of the 48 analogs analyzed showed promising results for bactericidal action against S. aureus. It is possible to conclude that ten of the 48 compounds derived from 2-naphthoic acid presented activity based on the prediction model generated, of which seven presented no toxicity and up to one violation to the Lipinski rule.

Current Topics in Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about 1219707-39-7. 1219707-39-7 belongs to oxazolidine, auxiliary class Other Aliphatic Heterocyclic,Oxazolidine,Chiral,Fluoride,Benzene,Amide,Alcohol,Anti-infection, name is (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one, and the molecular formula is C14H17FN4O3, Recommanded Product: (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Trabue, Steven published the artcileSpeciation of volatile organic compounds from poultry production, Formula: C5H7NO, the publication is Atmospheric Environment (2010), 44(29), 3538-3546, database is CAplus.

Volatile organic compounds (VOCs) emitted from poultry production are leading source of air quality problems. However, little is known about the speciation and levels of VOCs from poultry production The objective of this study was the speciation of VOCs from a poultry facility using evacuated canisters and sorbent tubes. Samples were taken during active poultry production cycle and between production cycles. Levels of VOCs were highest in areas with birds and the compounds in those areas had a higher percentage of polar compounds (89%) compared to aliphatic hydrocarbons (2.2%). In areas without birds, levels of VOCs were 1/3 those with birds present and compounds had a higher total percentage of aliphatic hydrocarbons (25%). Of the VOCs quantified in this study, no single sampling method was capable of quantifying more than 55% of compounds and in several sections of the building each sampling method quantified less than 50% of the quantifiable VOCs. Key classes of chems. quantified using evacuated canisters included both alcs. and ketones, while sorbent tube samples included volatile fatty acids and ketones. The top five compounds made up close to 70% of VOCs and included. 1; acetic acid (830.1 μg m^-3), 2; 2,3-butanedione (680.6 μg m^-3). 3; methanol (195.8 μg m^-3). 4; acetone (104.6 μg m^-3), and 5; ethanol (101.9 μg m^-3). Location variations for top five compounds averaged 49.5% in each section of the building and averaged 87% for the entire building.

Atmospheric Environment published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C15H14O3, Formula: C5H7NO.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Yoshizumi, Tomoki published the artcileSynthesis of 2,5-diaryloxazoles through van Leusen reaction and copper-mediated direct arylation, Related Products of oxazolidine, the publication is Tetrahedron Letters (2009), 50(26), 3273-3276, database is CAplus.

The direct arylation of 5-aryloxazoles, prepared by the van Leusen reaction, with various aryl iodides is effectively promoted by a system of CuI combined with PPh₃ and Na₂CO₃ as a ligand and a base, resp., in DMF to produce the corresponding 2,5-diaryloxazoles in good yields.

Tetrahedron Letters published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C8H10O2, Related Products of oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Ok, H. O. published the artcileSubstituted oxazole benzenesulfonamides as potent human β₃ adrenergic receptor agonists, Application In Synthesis of 72571-06-3, the publication is Bioorganic & Medicinal Chemistry Letters (2000), 10(14), 1531-1534, database is CAplus and MEDLINE.

As a part of our investigation into the development of orally bioavailable β₃ adrenergic receptor agonists, we have identified a series of substituted oxazole derivatives that are potent β₃ agonists with excellent selectivity against other β receptors. Several of these compounds showed excellent oral bioavailability in dogs. The cyclopentylethyloxazole (I) is a potent β₃ agonist (EC₅₀=14 nM, 84% activation) with 340-fold and 160-fold selectivity over β₁ and β₂ receptors, resp., and has 38% oral bioavailability in dogs.

Bioorganic & Medicinal Chemistry Letters published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Application In Synthesis of 72571-06-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Motamen, Sara published the artcileAnalysis of Approaches to Anti-tuberculosis Compounds, Formula: C14H17FN4O3, the publication is ACS Omega (2020), 5(44), 28529-28540, database is CAplus and MEDLINE.

Mycobacterium tuberculosis (Mtb) remains a deadly pathogen two decades after the announcement of tuberculosis (TB) as a global health emergency by the World Health Organization. Medicinal chem. efforts to synthesize potential drugs to shorten TB treatments have not always been successful. Here, we analyze physiochem. properties of 39 TB drugs and 1271 synthetic compounds reported in 40 publications from 2006 to early 2020. We also propose a new TB space of physiochem. properties that may provide more appropriate guidelines for design of anti-TB drugs.

ACS Omega published new progress about 1219707-39-7. 1219707-39-7 belongs to oxazolidine, auxiliary class Other Aliphatic Heterocyclic,Oxazolidine,Chiral,Fluoride,Benzene,Amide,Alcohol,Anti-infection, name is (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one, and the molecular formula is C14H17FN4O3, Formula: C14H17FN4O3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Vechorkin, Oleg published the artcileThe Nickel/Copper-Catalyzed Direct Alkylation of Heterocyclic C-H Bonds, Category: oxazolidine, the publication is Angewandte Chemie, International Edition (2010), 49(17), 3061-3064, S3061/1-S3061/94, database is CAplus and MEDLINE.

A combination of the Ni complex I and CuI gave efficient coupling of aromatic heterocycles with nonactivated alkyl halides containing a β-hydrogen atom. The chemo- and regioselectivities were excellent. E.g., alkylation of benzoxazole by octyl bromide gave 72% 2-octylbenzoxazole.

Angewandte Chemie, International Edition published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C4Br2N2O4S, Category: oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Foti, Claudia published the artcileOxazolidinone Antibiotics: Chemical, Biological and Analytical Aspects, Recommanded Product: (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one, the publication is Molecules (2021), 26(14), 4280, database is CAplus and MEDLINE.

A review. This review covers the main aspects concerning the chem., the biol. activity and the anal. determination of oxazolidinones, the only new class of synthetic antibiotics advanced in clin. use over the past 50 years. They are characterized by a chem. structure including the oxazolidone ring with the S configuration of substituent at C5, the acylaminomethyl group linked to C5 and the N-aryl substituent. The synthesis of oxazolidinones has gained increasing interest due to their unique mechanism of action that assures high antibiotic efficiency and low susceptibility to resistance mechanisms. Here, the main features of oxazolidinone antibiotics licensed or under development, such as Linezolid, Sutezolid, Eperezolid, Radezolid, Contezolid, Posizolid, Tedizolid, Delpazolid and TBI-223, are discussed. As they are protein synthesis inhibitors active against a wide spectrum of multidrug-resistant Gram-pos. bacteria, their biol. activity is carefully analyzed, together with the drug delivery systems recently developed to overcome the poor oxazolidinone water solubility Finally, the most employed anal. techniques for oxazolidinone determination in different matrixes, such as biol. fluids, tissues, drugs and natural waters, are reviewed. Most are based on HPLC (High Performance Liquid Chromatog.) coupled with UV-Vis or mass spectrometer detectors, but, to a lesser extent are also based on spectrofluorimetry or voltammetry.

Molecules published new progress about 1219707-39-7. 1219707-39-7 belongs to oxazolidine, auxiliary class Other Aliphatic Heterocyclic,Oxazolidine,Chiral,Fluoride,Benzene,Amide,Alcohol,Anti-infection, name is (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one, and the molecular formula is C14H17FN4O3, Recommanded Product: (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem