Day: November 21, 2022

Li, Bijin published the artcileDual-emissive 2-(2′-hydroxyphenyl)oxazoles for high performance organic electroluminescent devices: discovery of a new equilibrium of excited state intramolecular proton transfer with a reverse intersystem crossing process, Safety of 5-(4-Bromophenyl)oxazole, the publication is Chemical Science (2018), 9(5), 1213-1220, database is CAplus and MEDLINE.

The photoluminescence (PL) and electroluminescence (EL) properties of two highly efficient excited state intramol. proton transfer (ESIPT) mols., 2-(2′-hydroxyphenyl)oxazoles containing one triphenylamine (TPA) (1) and two TPAs (2) resp., are studied systematically. The enol-forms of both 1 and 2 possess highly hybridized local and charge transfer (HLCT) excited state character, while their excited-state keto-forms are not of obvious HLCT character. A 1-based device exhibits green-white electroluminescence with Commission Internationale de l’Eclairage (CIE) coordinates of (0.25, 0.41) and a high external quantum efficiency (EQE) up to 5.3%, which is the highest EQE value recorded for single mol. white light-emitting materials. A 2-based device shows sky-blue emission with CIE coordinates of (0.18, 0.16) and an EQE of 8.0%, which is the highest EQE in the reported HLCT materials. The fluorescence intensities of the enol-forms of 1 and 2 in EL spectra are increased remarkably relative to their PL spectra. Exptl. data and theor. calculations reveal a new ESIPT equilibrium with a reverse intersystem crossing (RISC) process arising from the HLCT character. In EL, the RISC of the enol-form excitons from the triplet state to the singlet state triggers an increase in the number of enol-form singlet excitons, which further leads to a shift of the ESIPT equilibrium towards an enhanced enol-form emission. Thus, the difference between the ESIPT equilibrium in PL and EL may be ascribed to the HLCT character of the enol-form excited state.

Chemical Science published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Safety of 5-(4-Bromophenyl)oxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Chen, Peng published the artcileDiscovery of novel, potent, isosteviol-based antithrombotic agents, Recommanded Product: 5-(4-Bromophenyl)oxazole, the publication is European Journal of Medicinal Chemistry (2019), 111722, database is CAplus and MEDLINE.

Thrombosis is a pathol. coagulation process and can lead to many serious thrombotic diseases. Here, we report a novel potent antithrombotic compound (6k) based on isosteviol with anticoagulant and antiplatelet activities. 6k selectively inhibited FXa (K_i = 0.015μM) against a panel of serine proteases and showed excellent anticoagulant activity (significant prolongation of ex vivo PT and aPTT over the vehicle, p < 0.01). 6k also significantly inhibited ADP-induced platelet aggregation in rats relative to the vehicle (p < 0.01). Furthermore, 6k exhibited potent ex vivo and in vivo antithrombotic activity in rats relative to the vehicle (p < 0.01 and p < 0.0001, resp.). Novel structure 6k, with potent antithrombotic activity, is expected to lead a promising approach for the development of antithrombotic agents.

European Journal of Medicinal Chemistry published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Recommanded Product: 5-(4-Bromophenyl)oxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Yang, Ke published the artcileNickel-catalyzed decarboxylative acylation of heteroarenes by sp² C-H functionalization, Category: oxazolidine, the publication is Chemistry – A European Journal (2014), 20(24), 7241-7244, database is CAplus and MEDLINE.

Nickel-catalyzed ligand-free decarboxylative cross-coupling of azole derivatives with α-oxoglyoxylic acids was developed. This work represents the first example of decarboxylative cross-coupling reactions, in a C-H bond functionalization manner, through nickel catalysis, and tolerates various functional groups. Addnl., this approach provides an efficient access to (ox)azole ketones, an important structural motif in many medicinal compounds with a broad range of biol. activities. © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemistry – A European Journal published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C8H7NO4, Category: oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Fullam, Elizabeth published the artcilePhysicochemical properties and Mycobacterium tuberculosis transporters: keys to efficacious antitubercular drugs?, Product Details of C14H17FN4O3, the publication is RSC Medicinal Chemistry (2021), 12(1), 43-56, database is CAplus and MEDLINE.

A review. Securing novel, safe, and effective medicines to treat Mycobacterium tuberculosis remains an elusive goal, particularly influenced by the largely impervious Mtb envelope that limits exposure and thus efficacy of inhibitors at their cellular and periplasmic targets. The impact of physicochem. properties on pharmacokinetic parameters that govern oral absorption and exposure at sites of infection is considered alongside how these properties influence penetration of the Mtb envelope, with the likely influence of transporter proteins. The findings are discussed to benchmark current drugs and the emerging pipeline, while considering tactics for future rational and targeted design strategies, based around emerging data on Mtb transporters and their structures and functions.

RSC Medicinal Chemistry published new progress about 1219707-39-7. 1219707-39-7 belongs to oxazolidine, auxiliary class Other Aliphatic Heterocyclic,Oxazolidine,Chiral,Fluoride,Benzene,Amide,Alcohol,Anti-infection, name is (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one, and the molecular formula is C14H17FN4O3, Product Details of C14H17FN4O3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Ding, Zhenhua published the artcileCobalt-Catalyzed Addition of Azoles to Alkynes, Quality Control of 72571-06-3, the publication is Organic Letters (2010), 12(18), 4180-4183, database is CAplus and MEDLINE.

A ternary catalytic system consisting of a cobalt salt, a diphosphine ligand, and a Grignard reagent promotes syn-addition of an azole C(2)-H bond across an unactivated internal alkyne with high chemo-, regio-, and stereoselectivities under mild conditions. Mechanistic experiments suggest that the reaction involves oxidative addition of the oxazolyl C-H bond to the cobalt center, alkyne insertion into the Co-H bond, and reductive elimination of the resulting diorganocobalt species.

Organic Letters published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Quality Control of 72571-06-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Shibamoto, Takayuki published the artcileFlavor in the cysteine-glucose model system prepared in microwave and conventional ovens, Recommanded Product: 4,5-Dimethyloxazole, the publication is ACS Symposium Series (1994), 457-65, database is CAplus.

Flavors created by cooking in a microwave oven and a conventional oven are significantly different. The difference is due to the formation, both in quality and quantity, of heterocyclic compounds The volatile heterocyclic compounds generated from an aqueous D-glucose/L-cysteine Maillard system upon microwave irradiation or conventional heating were isolated and identified by gas chromatog. and mass spectrometry. Heterocyclic compounds were formed in considerably higher amounts in the microwave-irradiated samples. They included thiazole, 2,5-dimethylthiazole, 4,5-dimethyloxazole, 2-methylpyridine, and 2,3-dihydro-3,5-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one. Compounds formed in significantly higher amounts in the conventionally heated samples were 2-methylpyrazine, 2,6-dimethylpyrazine, 2-furanmethanol, and 4-hydroxy-2,5-dimethyl-3(2H)-furanone. The lack of desirables cooked flavors in microwaved foods may be due to the absence of or decreased formation of pyrazines and furans. The flavor profiles of microwaved and conventionally heated foods suggest that the formation mechanisms of compounds, especially of pyrazines, are different. Various factors such as electrolytes, pH, and moisture content have been shown to alter the generation of volatiles and degree of browning in microwaved systems.

ACS Symposium Series published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C18H28B2O4, Recommanded Product: 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Yang, Ji published the artcileStudy on nonaqueous phase Maillard reaction of glucose/L-lysine model system, Safety of 4,5-Dimethyloxazole, the publication is Yancao Keji (2011), 55-61, 83, database is CAplus.

The thermogravimetric characteristics of glucose, L-lysine and their mixture were determined by thermogravimetry. The pyrolytic products of glucose and L-lysine mixture at 5 temperature ranges were analyzed by the combination of thermogravimetry, solid phase microextraction and gas chromatog.-mass spectrometry (TG-SPME-GC-MS). The effects of the proportion of glucose to L-lysine, and air flow on the yields of 2-ethyl-3,5-dimethylpyrazine and 3,5-diethyl-2-methylpyrazine were investigated as well. The results showed that : (1) the activation energy of reaction of glucose/L-lysine model system was far lower than that of degradation on their own. There was an endothermic process at the early reaction stage. In the temperature range of 135 to 245°C weight loss started, the mixture lost about 40% of its weight (2) 39 Compounds were identified in pyrolytic products of the model system. Ketones and furfurals were the main products at 100 to 250°C. From 250 to 350°C, pyrazine, pyridine, pyrrole, oxazole, imidazole and other nitrogenous heterocyclic compounds were detected. And the important flavor compounds were produced started from 150°C. (3) The yields of 2-ethyl-3,5-dimethylpyrazine and 3,5-diethyl-2-methylpyrazine culminated at air velocity of 200 mL/min and the mass ratio of glucose to L-lysine of 1:1.

Yancao Keji published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C18H34N4O5S, Safety of 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Wang, Shuai published the artcileFormal Carbene C-H Bond Insertion in the Cu(I)-Catalyzed Reaction of Bis(trimethylsilyl)diazomethane with Benzoxazoles and Oxazoles, SDS of cas: 72571-06-3, the publication is Organic Letters (2019), 21(6), 1809-1812, database is CAplus and MEDLINE.

A Cu(I)-catalyzed cross-coupling reaction of bis(trimethylsilyl)diazomethane and benzoxazoles/oxazoles is reported. A wide range of functional groups can be tolerated in this transformation. This reaction provides a new method to directly introduce a 1,1-bis(trimethylsilyl)methyl group into heteroaromatic C-H bonds. Subsequent transformations of 1,1-bis(trimethylsilyl)-methylated heteroaromatic compounds are also presented.

Organic Letters published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C12H21NO3, SDS of cas: 72571-06-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Wang, Shuai published the artcileFormal Carbene C-H Bond Insertion in the Cu(I)-Catalyzed Reaction of Bis(trimethylsilyl)diazomethane with Benzoxazoles and Oxazoles, Application In Synthesis of 20662-83-3, the publication is Organic Letters (2019), 21(6), 1809-1812, database is CAplus and MEDLINE.

A Cu(I)-catalyzed cross-coupling reaction of bis(trimethylsilyl)diazomethane and benzoxazoles/oxazoles is reported. A wide range of functional groups can be tolerated in this transformation. This reaction provides a new method to directly introduce a 1,1-bis(trimethylsilyl)methyl group into heteroaromatic C-H bonds. Subsequent transformations of 1,1-bis(trimethylsilyl)-methylated heteroaromatic compounds are also presented.

Organic Letters published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C15H14O3, Application In Synthesis of 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Zhang, Ling-Juan published the artcileTandem cycloaddition-decarboxylation of α-keto acid and isocyanide under oxidant-free conditions towards monosubstituted oxazoles, Related Products of oxazolidine, the publication is RSC Advances (2016), 6(77), 73450-73453, database is CAplus.

An efficient method, tandem [3+2] cycloaddition-decarboxylation of α-keto acid and isocyanide promoted by copper salt was developed. Under oxidant-free conditions, a series monosubstituted oxazoles was constructed. Different from the traditional application of α-oxo acids as acyl surrogates, the elegant approach ingeniously avoided consuming excess oxidants.

RSC Advances published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C25H29N9O3, Related Products of oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem