Day: November 10, 2022

Alternatives to Phosphinooxazoline (t-BuPHOX) Ligands in the Metal-Catalyzed Hydrogenation of Minimally Functionalized Olefins and Cyclic β-Enamides was written by Biosca, Maria; Magre, Marc; Coll, Merce; Pamies, Oscar; Dieguez, Montserrat. And the article was included in Advanced Synthesis & Catalysis in 2017.Recommanded Product: (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the article:

A new series of readily accessible iridium- and rhodium-phosphite/oxazoline catalytic systems that can efficiently hydrogenate, for the first time, both minimally functionalized olefins and functionalized olefins, such as Et 3-phenylbut-2-enoate, Et (2Z)-3-cyclohexyl-3-phenylprop-2-enoate, [(1E)-1-methyl-1-propen-1-yl]benzene, etc. (62 examples in total), with high enantioselectivities (up to >99% ee) and conversions has been reported. The phosphite-oxazoline ligands, which are readily available in only two synthetic steps, are derived from previous privileged 4-alkyl-2-[2-(diphenylphosphino)phenyl]-2-oxazoline (PHOX) ligands by replacing the phosphine moiety by a biaryl phosphite group and/or the introduction of a methylene spacer between the oxazoline and the Ph ring. The modular design of the ligands has given the opportunity not only to overcome the limitations of the iridium-PHOX catalytic systems in the hydrogenation of minimally functionalized Z-olefins and 1,1-disubstituted olefins, but also to expand their use to unfunctionalized olefins containing other challenging scaffolds (e.g., exocyclic benzo-fused and triaryl-substituted olefins) and also to olefins with poorly coordinative groups (e.g., α,β-unsaturated lactams, lactones, alkenylboronic esters, etc.) with enantioselectivities typically >95% ee. Moreover, both enantiomers of the hydrogenation product could be obtained by simply changing the configuration of the biaryl phosphite moiety. Remarkably, the new catalytic systems also provided excellent enantioselectivities (up to 99% ee) in the asym. hydrogenation of another challenging class of olefins – the functionalized cyclic β-enamides, such as N-(6-bromo-3,4-dihydronaphthalen-2-yl)acetamide, N-(2H-chromen-3-yl)acetamide, N-(8-methoxy-3,4-dihydronaphthalen-2-yl)acetamide, etc. Again, both enantiomers of the reduced amides could be obtained by changing the metal from Ir to Rh. The environmentally friendly propylene carbonate which can be used with no loss of enantioselectivity was also demonstrated. Another advantage of the new ligands over the PHOX ligands is that the best ligands are derived from the affordable (S)-phenylglycinol rather than from the expensive (S)-tert-leucinol. This study involved multiple reactions and reactants, such as (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8Recommanded Product: (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol).

(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Recommanded Product: (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol

135948-04-8;(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 135948-04-8;New trend of C13H17NO2;function of 135948-04-8

Half-Sandwich Ruthenium Phenolate-Oxazoline Complexes: Experimental and Theoretical Studies in Catalytic Transfer Hydrogenation of Nitroarene was written by Jia, Wei-Guo; Ling, Shuo; Zhang, Hai-Ning; Sheng, En-Hong; Lee, Richmond. And the article was included in Organometallics on January 8,2018.Related Products of 163165-91-1 The following contents are mentioned in the article:

Five Ru complexes [Ru(p-cymene)LCl] containing phenolate-oxazoline ligands [LH = 2-(4,5-dihydrooxazol-2-yl)phenol (1), 2-(4-methyl-4,5-dihydrooxazol-2-yl)phenol (2); L = 2-(4-ethyl-4,5-dihydrooxazol-2-yl)phenol (3), 2-(4-phenyl-4,5-dihydrooxazol-2-yl)phenol (4), 2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenol (5)] were synthesized and characterized. The solid-state structures of all Ru complexes were determined by single-crystal x-ray diffraction. The catalytic activities of these complexes in the transfer hydrogenation reaction of nitroarenes to anilines were studied. Aniline and their derivatives were obtained in good to excellent yields with iso-PrOH as the hydride source. The present protocol provides an environmentally benign synthetic method for the reduction of nitroarenes to anilines without employing harsh reaction conditions. Theor. studies employing d. functional theory were carried with the aim to propose a feasible reaction mechanism and to draw insights into the reactivity of the half-sandwich Ru catalyst. This study involved multiple reactions and reactants, such as 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1Related Products of 163165-91-1).

2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Related Products of 163165-91-1

163165-91-1;2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-91-1;New trend of C11H13NO2;function of 163165-91-1

The Role of the Achiral Template in Enantioselective Transformations. Radical Conjugate Additions to α-Methacrylates Followed by Hydrogen Atom Transfer was written by Sibi, Mukund P.; Sausker, Justin B.. And the article was included in Journal of the American Chemical Society on February 13,2002.Safety of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the article:

We have evaluated various achiral templates in conjunction with chiral Lewis acids in the conjugate addition of nucleophilic radicals to α-methacrylates followed by enantioselective H-atom transfer. Of these, a novel naphthosultam template I gave high enantioselectivity in the H-atom-transfer reactions with ee’s up to 90%. A chiral Lewis acid derived from MgBr2 and a bisoxazoline gave the highest selectivity in the enantioselective hydrogen-atom-transfer reactions. Non-C2 sym. oxazolines have also been examined as ligands, and of these, compound II gave optimal results (87% yield and 80% ee). Insights into rotamer control in α-substituted acrylates and the critical role of the tetrahedral sulfone moiety in realizing high selectivity are discussed. This study involved multiple reactions and reactants, such as (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4Safety of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol).

(R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Chiral oxazolidines are widely used as chiral auxiliaries, chiral ligands, protecting and/or directing groups in a variety of asymmetric transformations, thanks also to their easy cleavage or their further elaboration possibilities.Safety of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol

150699-08-4;(R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol;The future of 150699-08-4;New trend of C15H13NO2;function of 150699-08-4

Ligand Design for Isomer-Selective Oxorhenium(V) Complex Synthesis was written by Liu, Jinyong; Su, Xiaoge; Han, Mengwei; Wu, Dimao; Gray, Danielle L.; Shapley, John R.; Werth, Charles J.; Strathmann, Timothy J.. And the article was included in Inorganic Chemistry on February 6,2017.Synthetic Route of C16H15NO2 The following contents are mentioned in the article:

Recently, N,N-trans Re(O)(LN-O)2X (LN-O = monoanionic N-O chelates; X = Cl or Br prior to being replaced by solvents or alkoxides) complexes are superior to the corresponding N,N-cis isomers in the catalytic reduction of perchlorate via oxygen atom transfer. However, reported methods for Re(O)(LN-O)2X synthesis often yield only the N,N-cis complex or a mixture of trans and cis isomers. This study reports a geometry-inspired ligand design rationale that selectively yields N,N-trans Re(O)(LN-O)2Cl complexes. Anal. of the crystal structures revealed that the dihedral angles (DAs) between the two LN-O ligands of N,N-cis Re(O)(LN-O)2Cl complexes are <90°, whereas the DAs in most N,N-trans complexes are >90°. Variably sized alkyl groups (-Me, -CH2Ph, and -CH2Cy) were then introduced to the 2-(2′-hydroxyphenyl)-2-oxazoline (Hhoz) ligand to increase steric hindrance in the N,N-cis structure, and substituents as small as -Me completely eliminate the formation of N,N-cis isomers. The generality of the relation between N,N-trans/cis isomerism and DAs is further established from a literature survey of 56 crystal structures of Re(O)(LN-O)2X, Re(O)(LO-N-N-O)X, and Tc(O)(LN-O)2X congeners. D. functional theory calculations support the general strategy of introducing ligand steric hindrance to favor synthesis of N,N-trans Re(O)(LN-O)2X and Tc(O)(LN-O)2X complexes. This study demonstrates the promise of applying rational ligand design for isomeric control of metal complex structures, providing a path forward for innovations in a number of catalytic, environmental, and biomedical applications. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Synthetic Route of C16H15NO2).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Synthetic Route of C16H15NO2

163165-92-2;(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-92-2;New trend of C16H15NO2;function of 163165-92-2

Ligand Design for Isomer-Selective Oxorhenium(V) Complex Synthesis was written by Liu, Jinyong; Su, Xiaoge; Han, Mengwei; Wu, Dimao; Gray, Danielle L.; Shapley, John R.; Werth, Charles J.; Strathmann, Timothy J.. And the article was included in Inorganic Chemistry on February 6,2017.Category: oxazolidine The following contents are mentioned in the article:

Recently, N,N-trans Re(O)(LN-O)2X (LN-O = monoanionic N-O chelates; X = Cl or Br prior to being replaced by solvents or alkoxides) complexes are superior to the corresponding N,N-cis isomers in the catalytic reduction of perchlorate via oxygen atom transfer. However, reported methods for Re(O)(LN-O)2X synthesis often yield only the N,N-cis complex or a mixture of trans and cis isomers. This study reports a geometry-inspired ligand design rationale that selectively yields N,N-trans Re(O)(LN-O)2Cl complexes. Anal. of the crystal structures revealed that the dihedral angles (DAs) between the two LN-O ligands of N,N-cis Re(O)(LN-O)2Cl complexes are <90°, whereas the DAs in most N,N-trans complexes are >90°. Variably sized alkyl groups (-Me, -CH2Ph, and -CH2Cy) were then introduced to the 2-(2′-hydroxyphenyl)-2-oxazoline (Hhoz) ligand to increase steric hindrance in the N,N-cis structure, and substituents as small as -Me completely eliminate the formation of N,N-cis isomers. The generality of the relation between N,N-trans/cis isomerism and DAs is further established from a literature survey of 56 crystal structures of Re(O)(LN-O)2X, Re(O)(LO-N-N-O)X, and Tc(O)(LN-O)2X congeners. D. functional theory calculations support the general strategy of introducing ligand steric hindrance to favor synthesis of N,N-trans Re(O)(LN-O)2X and Tc(O)(LN-O)2X complexes. This study demonstrates the promise of applying rational ligand design for isomeric control of metal complex structures, providing a path forward for innovations in a number of catalytic, environmental, and biomedical applications. This study involved multiple reactions and reactants, such as 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1Category: oxazolidine).

2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Category: oxazolidine

163165-91-1;2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-91-1;New trend of C11H13NO2;function of 163165-91-1

Octahedral Ruthenium Complex with Exclusive Metal-Centered Chirality for Highly Effective Asymmetric Catalysis was written by Zheng, Yu; Tan, Yuqi; Harms, Klaus; Marsch, Michael; Riedel, Radostan; Zhang, Lilu; Meggers, Eric. And the article was included in Journal of the American Chemical Society on March 29,2017.HPLC of Formula: 1045894-43-6 The following contents are mentioned in the article:

A novel Ru catalyst is introduced which contains solely achiral ligands and acquires its chirality entirely from octahedral centrochirality. The configurationally stable catalyst is demonstrated to catalyze the alkynylation of trifluoromethyl ketones with very high enantioselectivity (up to >99% ee) at low catalyst loadings (down to 0.2 mol%). This study involved multiple reactions and reactants, such as (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6HPLC of Formula: 1045894-43-6).

(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6) belongs to oxazolidine derivatives. A common way to produce multisubstituted oxazolidines is by means of cycloaddition reactions. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.HPLC of Formula: 1045894-43-6

1045894-43-6;(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol;The future of 1045894-43-6;New trend of C12H15NO2;function of 1045894-43-6

Chiral-at-Iron Catalyst: Expanding the Chemical Space for Asymmetric Earth-Abundant Metal Catalysis was written by Hong, Yubiao; Jarrige, Lucie; Harms, Klaus; Meggers, Eric. And the article was included in Journal of the American Chemical Society on March 20,2019.Reference of 1045894-43-6 The following contents are mentioned in the article:

A new class of chiral iron catalysts is introduced that contains exclusively achiral ligands with the overall chirality being the result of a stereogenic iron center. Specifically, iron(II) is cis-coordinated to two N-(2-pyridyl)-substituted N-heterocyclic carbene (PyNHC) ligands in a bidentate fashion in addition to two monodentate acetonitriles, and the dicationic complex is complemented by two hexafluorophosphate ions. Depending on the helical twist of the PyNHC ligands, the metal center adopts either a Λ or Δ absolute configuration. Importantly, the two PyNHC ligands are constitutionally and configurationally inert, while the two acetonitriles are labile and allow asym. transition metal catalysis. This is demonstrated with an enantioselective Cannizzaro reaction (96% yield, 88% ee) and an asym. Nazarov cyclization (89% yield, >20:1 dr, 83% ee). This study involved multiple reactions and reactants, such as (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6Reference of 1045894-43-6).

(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Reference of 1045894-43-6

1045894-43-6;(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol;The future of 1045894-43-6;New trend of C12H15NO2;function of 1045894-43-6

2-(4′,4′-Dimethyl-3′,4′-dihydrooxazol-2′-yl)phenol: some first-row transition metal complexes of this naturally occurring binding group was written by Mugesh, Govindasamy; Singh, Harkesh B.; Butcher, Ray J.. And the article was included in European Journal of Inorganic Chemistry on March 31,2001.Formula: C11H13NO2 The following contents are mentioned in the article:

The synthesis and characterization of monomeric MnIII, CoII, NiII, CuII, and ZnII phenolates derived from a biol. relevant ligand, 2-(4′,4′-dimethyl-3′,4′-dihydrooxazol-2′-yl)phenol (1), are described. The addition of Mn(OAc)2·4H2O to an EtOH solution of 1 affords an unexpected 1:3 [Mn(OR){O(Ox)}2] (2) [R = o-C6H4CONHC(Me2)CH2OH, Ox = 2-(4,4-dimethyl-2-oxazolinyl)phenyl] in which one of the five-membered oxazoline rings is partially hydrolyzed. [M{O(Ox)}2] [M = Co (3), Ni (4), Cu (6), or Zn (7)] were prepared in good yield by the reactions of 1 with the corresponding metal acetates. Novel formation of the six-coordinate NiII complex (Ni{O(Ox)}2(OAc)2, 5) with neutral HOAc was observed during the crystallization process. The complexes were characterized by elemental anal., magnetic susceptibility, as well as EPR, 1H NMR, electronic, and mass spectral techniques. 2, 3, 5, 6, And 7 were characterized by single crystal x-ray diffraction studies. 2 Is six-coordinate whereas 3, 6, and 7 are four-coordinate with two bidentate oxazoline ligands. The geometry around the metal center is distorted tetrahedral for all of the four-coordinate complexes. Complex 5 is octahedral with four coordination sites occupied by the two bidentate oxazoline ligands and the other two are occupied by two neutral HOAc mols. The hydroxy groups of the coordinated HOAc are H-bonded to the phenolate O atoms of the oxazoline ligands. The variable-temperature 1H NMR spectroscopic studies of 7 indicate that the interconversion between the (M) and (P) helix is slow at low temperatures This study involved multiple reactions and reactants, such as 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1Formula: C11H13NO2).

2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Chiral oxazolidines are widely used as chiral auxiliaries, chiral ligands, protecting and/or directing groups in a variety of asymmetric transformations, thanks also to their easy cleavage or their further elaboration possibilities.Formula: C11H13NO2

163165-91-1;2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-91-1;New trend of C11H13NO2;function of 163165-91-1

New phosphite-oxazoline ligands for efficient Pd-catalyzed substitution reactions was written by Pamies, Oscar; Dieguez, Montserrat; Claver, Carmen. And the article was included in Journal of the American Chemical Society on March 23,2005.Recommanded Product: 150699-08-4 The following contents are mentioned in the article:

Nonracemic oxazolinylphenoxy dibenzodioxaphosphepines I (R = Me3C, Ph, Me2CH, Et, H; R1 = H, Ph; R2 = H, Me3C; R3 = H, MeO, Me3C) are prepared from nonracemic oxazolinylphenols and phosphochloridites generated in situ from substituted biphenyldiols; I act as catalysts for enantioselective palladium-catalyzed allylic substitution reactions of cyclic and acyclic allylic acetates with di-Me malonate and benzylamine to give allylic malonates and allylic amines in up to 99% yields and in 42-99% ee. Reaction of 2,2′-biphenols with phosphorus trichloride followed by the addition of nonracemic 4-substituted-2-(2-hydroxyphenyl)oxazolines yields I. In the presence of ligands I (R = H, Ph; R1 = Ph, H; R2 = R3 = Me3C), bis(allylpalladium chloride) acts as a catalyst for enantioselective allylic substitution reactions of 1,3-diphenyl-2-propenyl acetate with either di-Me malonate or benzylamine to yield PhCH:CHCHPhCH(CO2Me)2 or PhCH:CHCHPhNHCH2Ph in 100% conversion and in 98-99% ee. Other allylic acetates such as 3-penten-2-ol acetate, 2-cyclohexenyl acetate, and 1-phenyl-2-propenol acetate undergo palladium-catalyzed regioselective and enantioselective allylic substitution reactions with di-Me malonate to yield products in 74-99% ee; with 1-phenyl-2-propen-1-ol acetate, the product is obtained as a 68:32 mixture of regioisomers with the major regioisomer formed in 86% ee, while 1-(1-naphthyl)-2-propen-1-ol acetate gives a single regioisomer in 92% ee, with both substitution products formed in 100% yield. Ligands I afford excellent reaction rates and enantioselectivities while possessing broad scopes for different substrate types. This study involved multiple reactions and reactants, such as (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4Recommanded Product: 150699-08-4).

(R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Recommanded Product: 150699-08-4

150699-08-4;(R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol;The future of 150699-08-4;New trend of C15H13NO2;function of 150699-08-4

New phosphite-oxazoline ligands for efficient Pd-catalyzed substitution reactions was written by Pamies, Oscar; Dieguez, Montserrat; Claver, Carmen. And the article was included in Journal of the American Chemical Society on March 23,2005.COA of Formula: C13H17NO2 The following contents are mentioned in the article:

Nonracemic oxazolinylphenoxy dibenzodioxaphosphepines I (R = Me3C, Ph, Me2CH, Et, H; R1 = H, Ph; R2 = H, Me3C; R3 = H, MeO, Me3C) are prepared from nonracemic oxazolinylphenols and phosphochloridites generated in situ from substituted biphenyldiols; I act as catalysts for enantioselective palladium-catalyzed allylic substitution reactions of cyclic and acyclic allylic acetates with di-Me malonate and benzylamine to give allylic malonates and allylic amines in up to 99% yields and in 42-99% ee. Reaction of 2,2′-biphenols with phosphorus trichloride followed by the addition of nonracemic 4-substituted-2-(2-hydroxyphenyl)oxazolines yields I. In the presence of ligands I (R = H, Ph; R1 = Ph, H; R2 = R3 = Me3C), bis(allylpalladium chloride) acts as a catalyst for enantioselective allylic substitution reactions of 1,3-diphenyl-2-propenyl acetate with either di-Me malonate or benzylamine to yield PhCH:CHCHPhCH(CO2Me)2 or PhCH:CHCHPhNHCH2Ph in 100% conversion and in 98-99% ee. Other allylic acetates such as 3-penten-2-ol acetate, 2-cyclohexenyl acetate, and 1-phenyl-2-propenol acetate undergo palladium-catalyzed regioselective and enantioselective allylic substitution reactions with di-Me malonate to yield products in 74-99% ee; with 1-phenyl-2-propen-1-ol acetate, the product is obtained as a 68:32 mixture of regioisomers with the major regioisomer formed in 86% ee, while 1-(1-naphthyl)-2-propen-1-ol acetate gives a single regioisomer in 92% ee, with both substitution products formed in 100% yield. Ligands I afford excellent reaction rates and enantioselectivities while possessing broad scopes for different substrate types. This study involved multiple reactions and reactants, such as (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8COA of Formula: C13H17NO2).

(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.COA of Formula: C13H17NO2

135948-04-8;(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 135948-04-8;New trend of C13H17NO2;function of 135948-04-8