Day: November 10, 2022

Synthesis of Air- and Moisture-Stable, Storable Chiral Oxorhenium Complexes and Their Application as Catalysts for the Enantioselective Imine Reduction was written by Das, Braja Gopal; Nallagonda, Rajender; Dey, Dhananjay; Ghorai, Prasanta. And the article was included in Chemistry – A European Journal in 2015.SDS of cas: 163165-92-2 The following contents are mentioned in the article:

Air-/moisture-stable, crystalline, and storable chiral salicyloxazoline based oxorhenium(V) complexes were synthesized and their catalytic application for the asym. reduction of ketimines using hydrosilane as hydride source was disclosed. A broad substrate scope, high yields, and excellent enantioselectivities (up to 99 %) were attained. Furthermore, the syntheses of enantiopure α-amino esters, γ- and δ-lactams, and isoindolinones were also carried out using this methodol. Finally, the method was applied to synthetic targets of pharmaceutical relevance, such as R-(+)-salsolidine and R-(+)-crispine A. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2SDS of cas: 163165-92-2).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.SDS of cas: 163165-92-2

163165-92-2;(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-92-2;New trend of C16H15NO2;function of 163165-92-2

Synthesis of Air- and Moisture-Stable, Storable Chiral Oxorhenium Complexes and Their Application as Catalysts for the Enantioselective Imine Reduction was written by Das, Braja Gopal; Nallagonda, Rajender; Dey, Dhananjay; Ghorai, Prasanta. And the article was included in Chemistry – A European Journal in 2015.Computed Properties of C13H17NO2 The following contents are mentioned in the article:

Air-/moisture-stable, crystalline, and storable chiral salicyloxazoline based oxorhenium(V) complexes were synthesized and their catalytic application for the asym. reduction of ketimines using hydrosilane as hydride source was disclosed. A broad substrate scope, high yields, and excellent enantioselectivities (up to 99 %) were attained. Furthermore, the syntheses of enantiopure α-amino esters, γ- and δ-lactams, and isoindolinones were also carried out using this methodol. Finally, the method was applied to synthetic targets of pharmaceutical relevance, such as R-(+)-salsolidine and R-(+)-crispine A. This study involved multiple reactions and reactants, such as (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8Computed Properties of C13H17NO2).

(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.Computed Properties of C13H17NO2

135948-04-8;(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 135948-04-8;New trend of C13H17NO2;function of 135948-04-8

Chiral-at-Ruthenium Catalyst with Sterically Demanding Furo[3,2-b]pyridine Ligands was written by Cui, Tianjiao; Qin, Jie; Harms, Klaus; Meggers, Eric. And the article was included in European Journal of Inorganic Chemistry in 2019.Product Details of 1045894-43-6 The following contents are mentioned in the article:

A sterically demanding derivative of a previously introduced chiral-at-metal ruthenium(II) catalyst scaffold, I (Λ-3, Δ-3; Ar = 2,4,6-Me3C6H2) is introduced. It is composed of two bidentate furo[3,2-b]pyridyl functionalized N-heterocyclic carbene ligands. Their cis-coordination generates helical chirality and a stereogenic ruthenium center. Two addnl. labile acetonitriles compose the catalytic site which is highly shielded by two 2-(tert-butyl)furo[3,2-b]pyridine moieties. The synthesis of the non-racemic ruthenium catalyst and its catalytic properties for the enantioselective alkynylation of 2,2,2-trifluoroacetophenone and pentafluorobenzaldehyde are reported and compared with sterically less demanding derivatives This study involved multiple reactions and reactants, such as (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6Product Details of 1045894-43-6).

(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Product Details of 1045894-43-6

1045894-43-6;(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol;The future of 1045894-43-6;New trend of C12H15NO2;function of 1045894-43-6

Adding the right (or left) twist to tris-chelate complexes – coordination chemistry of chiral oxazolylphenolates with M3+ ions (M = Al or lanthanide) was written by Aspinall, Helen C.; Bacsa, John; Beckingham, Oliver D.; Eden, Edward G. B.; Greeves, Nicholas; Hobbs, Matthew D.; Potjewyd, Frances; Schmidtmann, Marc; Thomas, Christopher D.. And the article was included in Dalton Transactions in 2014.Electric Literature of C11H13NO2 The following contents are mentioned in the article:

Homoleptic tris-chelate complexes ML3 (M = Al or rare earth; L = chiral or achiral oxazolyl-phenolate or -naphtholate) is reported. In all cases, complexes crystallize as mer-isomers and complete diastereoselectivity is observed on crystallization of the complexes: ML3 crystallize with Λ-helicity at the metal where L = (S)-oxazolylphenolate. Complexes were characterized in solution by NMR spectroscopy, demonstrating rapid ligand exchange at ambient temperature for rare earth complexes, and slow exchange on the NMR timescale for complexes of Al; in all cases the mer-isomer is observed exclusively. Crystal structures are reported for [YL3]2 (L = (S)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-phenolate), mer-[YbL3] (L = (S)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenolate) and mer-[AlL3] (L = (S)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenolate, (S)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-cyanophenolate, (S)-1-(4-isopropyl-4,5-dihydrooxazol-2-yl)naphthalen-2-olate, 1-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)naphthalen-2-olate). This study involved multiple reactions and reactants, such as 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1Electric Literature of C11H13NO2).

2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Electric Literature of C11H13NO2

163165-91-1;2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-91-1;New trend of C11H13NO2;function of 163165-91-1

Adding the right (or left) twist to tris-chelate complexes – coordination chemistry of chiral oxazolylphenolates with M3+ ions (M = Al or lanthanide) was written by Aspinall, Helen C.; Bacsa, John; Beckingham, Oliver D.; Eden, Edward G. B.; Greeves, Nicholas; Hobbs, Matthew D.; Potjewyd, Frances; Schmidtmann, Marc; Thomas, Christopher D.. And the article was included in Dalton Transactions in 2014.Computed Properties of C16H15NO2 The following contents are mentioned in the article:

Homoleptic tris-chelate complexes ML3 (M = Al or rare earth; L = chiral or achiral oxazolyl-phenolate or -naphtholate) is reported. In all cases, complexes crystallize as mer-isomers and complete diastereoselectivity is observed on crystallization of the complexes: ML3 crystallize with Λ-helicity at the metal where L = (S)-oxazolylphenolate. Complexes were characterized in solution by NMR spectroscopy, demonstrating rapid ligand exchange at ambient temperature for rare earth complexes, and slow exchange on the NMR timescale for complexes of Al; in all cases the mer-isomer is observed exclusively. Crystal structures are reported for [YL3]2 (L = (S)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-phenolate), mer-[YbL3] (L = (S)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenolate) and mer-[AlL3] (L = (S)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenolate, (S)-2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-cyanophenolate, (S)-1-(4-isopropyl-4,5-dihydrooxazol-2-yl)naphthalen-2-olate, 1-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)naphthalen-2-olate). This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Computed Properties of C16H15NO2).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds are well-known chiral auxiliaries and strategic molecular moieties in chemistry since they can effectively mask or mimic amino acid units or amino alcohols. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Computed Properties of C16H15NO2

163165-92-2;(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-92-2;New trend of C16H15NO2;function of 163165-92-2

Synthesis and biological evaluation of 2-oxazoline and salicylic acid derivatives was written by Djurendic, Evgenija; Dojcinovic Vujaskovic, Sanja; Sakac, Marija; Ajdukovic, Jovana; Gakovic, Andrea; Kojic, Vesna; Bogdanovic, Gordana; Klisuric, Olivera; Penov Gasi, Katarina. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2011.Synthetic Route of C11H13NO2 The following contents are mentioned in the article:

Starting from Me salicylate and 2-amino-2-(hydroxymethyl)propane-1,3-diol, or 2-amino-2-methylpropane-1-ol, the 2-oxazoline derivatives of salicylic acid were synthesized. Reactions were performed by microwave irradiation in the presence of tetrabutylammonium bromide or metallic sodium as catalyst, as well as by conventional heating. Microwave-induced reaction of some diols, diamines and amino alcs. with Me salicylate gave mono- and/or bis- derivatives of salicylic acid. The mono- and bis-salicyloyl derivatives were transformed to the corresponding phenyl-azo derivatives The structure of one of the synthesized compound was proved by the X-ray anal. and the R-configuration on its stereocenter was confirmed. The antioxidant and cytotoxic activities of the synthesized derivatives were evaluated in a series of in vitro tests. Some of the compounds e,g., I, exhibited very strong activity against hydroxyl radical. Six tested compounds inhibited growth of MDA-MB-231 cells at a nanomolar concentration Two of the compounds e.g., II, showed high cytotoxicity against MCF7 cells, whereas four of the compounds showed high activity against K562 cells. This study involved multiple reactions and reactants, such as 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1Synthetic Route of C11H13NO2).

2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Chiral oxazolidines are widely used as chiral auxiliaries, chiral ligands, protecting and/or directing groups in a variety of asymmetric transformations, thanks also to their easy cleavage or their further elaboration possibilities.Synthetic Route of C11H13NO2

163165-91-1;2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-91-1;New trend of C11H13NO2;function of 163165-91-1

Method for the Preparation of Nonracemic Bis-Cyclometalated Iridium(III) Complexes was written by Helms, Melanie; Lin, Zhijie; Gong, Lei; Harms, Klaus; Meggers, Eric. And the article was included in European Journal of Inorganic Chemistry in 2013.Recommanded Product: 135948-04-8 The following contents are mentioned in the article:

A practical strategy for the generation of virtually enantiomerically pure bis-cyclometalated iridium(III) complexes is reported. Accordingly, the reactions of [Ir(μ-Cl)(ppy)2]2 (ppy = cyclometalating 2-phenylpyridine) with (S)-4-tert-butyl-2-(2′-hydroxyphenyl)-2-oxazoline [(S)-1a], [Ir(μ-Cl)(pq)2]2 (pq = cyclometalating 2-phenylquinoline) with (S)-2-(2′-hydroxyphenyl)-4-isopropyl-2-oxazoline [(S)-1b], and [Ir(μ-Cl)(pbt)2]2 (pbt = cyclometalating 2-phenylbenzothiazole) with (S)-2-(2′-hydroxyphenyl)-4-isopropyl-2-thiazoline [(S)-1d] afforded diastereomeric mixtures of salicyloxazolinato or salicylthiazolinato complexes Λ/Δ-[Ir(ppy)2{(S)-1a-H}]PF6, Λ/Δ-[Ir(pq)2{(S)-1b-H}]PF6, and Λ/Δ-[Ir(pbt)2{(S)-1d-H}]PF6, resp., which could be resolved by silica gel flash chromatog. With the individual diastereomers in hand, an acid-induced substitution of the chiral auxiliaries by achiral bidentate ligands with retention of configuration afforded several iridium complexes Λ- or Δ-[Ir(C-N)2(N N)]PF6 (C-N = cyclometalating ppy, pq, or pbt; N N = 2,2′-bipyridine, 1,10-phenanthroline, or 2,2′-biquinoline) with enantiomeric ratio (er) values of 24:1 to 230:1. This study involved multiple reactions and reactants, such as (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8Recommanded Product: 135948-04-8).

(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Recommanded Product: 135948-04-8

135948-04-8;(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 135948-04-8;New trend of C13H17NO2;function of 135948-04-8

Inhibition of the Ras/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(III) metal-based compound was written by Liu, Li-Juan; Wang, Wanhe; Huang, Shi-Ying; Hong, Yanjun; Li, Guodong; Lin, Sheng; Tian, Jinglin; Cai, Zongwei; Wang, Hui-Min David; Ma, Dik-Lung; Leung, Chung-Hang. And the article was included in Chemical Science in 2017.Recommanded Product: (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the article:

Targeting protein-protein interactions (PPIs) offers tantalizing opportunities for therapeutic intervention for the treatment of human diseases. Modulating PPI interfaces with organic small mols. has been found to be exceptionally challenging, and few candidates have been successfully developed into clin. drugs. Meanwhile, the striking array of distinctive properties exhibited by metal compounds renders them attractive scaffolds for the development of bioactive leads. Here, we report the identification of iridium(III) compounds as inhibitors of the H-Ras/Raf-1 PPI. The lead iridium(III) compound 1 exhibited potent inhibitory activity against the H-Ras/Raf-1 interaction and its signaling pathway in vitro and in vivo, and also directly engaged both H-Ras and Raf-1-RBD in cell lysates. Moreover, 1 repressed tumor growth in a mouse renal xenograft tumor model. Intriguingly, the Δ-enantiomer of 1 showed superior potency in the biol. assays compared to Λ-1 or racemic 1. These compounds could potentially be used as starting scaffolds for the development of more potent Ras/Raf PPI inhibitors for the treatment of kidney cancer or other proliferative diseases. This study involved multiple reactions and reactants, such as (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8Recommanded Product: (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol).

(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Recommanded Product: (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol

135948-04-8;(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 135948-04-8;New trend of C13H17NO2;function of 135948-04-8

Stereoisomers and functional groups in oxidorhenium(V) complexes: effects on catalytic activity was written by Schachner, J. A.; Berner, B.; Belaj, F.; Moesch-Zanetti, N. C.. And the article was included in Dalton Transactions in 2019.Quality Control of 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the article:

The syntheses of oxidorhenium(V) complexes [ReOCl(L1a-c)2] (3a-c), equipped with the bidentate, mono-anionic phenol-dimethyloxazoline ligands HL1a-c are described. Ligands HL1b-c contain functional groups on the phenol ring, compared to parent ligand 2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-phenol H1a; namely a methoxy group ortho to the hydroxyl position (2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-6-methoxyphenol, H1b), or a nitro group para to the hydroxyl position (2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-4-nitrophenol, H1c). Furthermore, oxidorhenate(V) complexes (NBu4)[ReOCl3(L1a-b)] (2a-b) were synthesized for solid state structural comparisons to 3a-b. All novel complexes are fully characterized including NMR, IR and UV-Vis spectroscopy, MS spectrometry, X-ray crystallog., elemental anal. as well as cyclic voltammetry. The influence of functional groups (R = -H, -OMe and -NO2) on the catalytic activity of 3a-c was investigated in two benchmark catalytic reactions, namely cyclooctene epoxidation and perchlorate reduction In addition, the previously described oxidorhenium(V) complex [ReOCl(oz)2] (4), employing the phenol-oxazoline ligand 2-(4,5-dihydro-2-oxazolyl)phenol Hoz, was included in these catalysis studies. Complex 4 is a rare case in oxidorhenium(V) chem. where two stereoisomers could be separated and fully characterized. With respect to the position of the oxazoline nitrogen atoms on the rhenium atom, these two stereoisomers are referred to as N,N-cis and N,N-trans isomer. A potential correlation between spectroscopic and structural data to catalytic activity was evaluated. This study involved multiple reactions and reactants, such as 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1Quality Control of 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol).

2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. In another report, the incorporation of an additional substituted oxazolidine ring over a range of new biphenylazepinium salt organocatalysts for the asymmetric epoxidation of alkenes improved enantiocontrol over the parent structures.Quality Control of 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol

163165-91-1;2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-91-1;New trend of C11H13NO2;function of 163165-91-1

Isomers in chlorido and alkoxido-substituted oxidorhenium(V) complexes: effects on catalytic epoxidation activity was written by Schachner, Joerg A.; Belaj, Ferdinand; Moesch-Zanetti, Nadia C.. And the article was included in Dalton Transactions in 2020.Reference of 163165-91-1 The following contents are mentioned in the article:

The syntheses and characterizations of oxidorhenium(V) complexes trans-dichlorido [ReOCl2(PPh3)(L1a)] (trans-2a), cis-dichlorido [ReOCl2(PPh3)(L1b)] (cis-2b) and ethoxido-complex [ReO(OEt)(L1b)2] (4b), ligated with the dimethyloxazoline-phenol ligands HL1a and HL1b are described. The bidentate ligand HL1a (2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)phenol) is unsubstituted on the phenol ring; ligand HL1b (2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-4-nitrophenol) contains a nitro group in para-position to the hydroxy group. In the reaction of precursor complex [ReOCl3(PPh3)2] and HL1a the two stereoisomers cis/trans-2a, with respect to chlorido ligands, are formed. The solid state structures of both isomers cis- and trans-2a were determined by single crystal x-ray diffraction anal. In contrast, with ligand HL1b, only the cis-isomer cis-2b was obtained. Ethoxido-complex 4b is exclusively obtained when precursor [ReOCl3(OPPh3)(SMe2)] is reacted with 2 equiv of HL1b in ethanol in the presence of the base 2,6-dimethylpyridine (lutidine). If no lutidine was added, chlorido-complex [ReOCl(L1b)2] (3b) was obtained. Complexes [ReOCl2(PPh3)(L1a)] (cis/trans-2a), [ReOCl2(PPh3)(L1b)] (cis-2b), [ReO(OMe)(L1a)2] (4a) and [ReO(OEt)(L1b)2] (4b) were tested as homogeneous catalysts in the benchmark reaction of cyclooctene epoxidation The influence of isomerism and effects of ligand substitutions on catalytic activity was studied. Based on the time-conversion plots cis/trans-isomerism does not influence catalytic activity, but electron-withdrawing substituents, as in cis-2b, 3b and 4b, show a beneficial effect. This study involved multiple reactions and reactants, such as 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1Reference of 163165-91-1).

2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Reference of 163165-91-1

163165-91-1;2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-91-1;New trend of C11H13NO2;function of 163165-91-1