November 10, 2022 | Page 2 of 6 | Heterocyclic Building Blocks-Oxazolidine

Haftchenary, Sina’s team published research in ACS Combinatorial Science in 2016-09-12 | CAS: 4042-43-7

ACS Combinatorial Science published new progress about Amino alcohols, chiral Role: RCT (Reactant), RACT (Reactant or Reagent). 4042-43-7 belongs to class oxazolidine, name is (R)-4-Methyloxazolidin-2-one, and the molecular formula is C4H7NO2, Safety of (R)-4-Methyloxazolidin-2-one.

Haftchenary, Sina published the artcileEfficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments, Safety of (R)-4-Methyloxazolidin-2-one, the main research area is amino alc chiral fragment reaction; oxazolidinone morpholinone lactam sultam preparation reaction; amino alcohols; chiral fragments; drug discovery; fragment-based lead discovery.

Efficient syntheses of chiral fragments derived from chiral amino alcs. are described. Several unique scaffolds were readily accessed in 1-5 synthetic steps leading to 45 chiral fragments, including five- to seven-membered oxazolidinones, morpholinones, lactams, and sultams. These fragments have mol. weights ranging from 100 to 255 Da and are soluble in water (0.085 to >15 mM).

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Kelly, Sean M.’s team published research in Organic Letters in 2017-06-02 | CAS: 4042-43-7

Organic Letters published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent) (addnl. nucleophile class). 4042-43-7 belongs to class oxazolidine, name is (R)-4-Methyloxazolidin-2-one, and the molecular formula is C4H7NO2, Computed Properties of 4042-43-7.

Kelly, Sean M. published the artcileChemoselective Copper-Catalyzed Ullmann-Type Coupling of Oxazolidinones with Bromoiodoarenes, Computed Properties of 4042-43-7, the main research area is chemoselective copper catalyzed Ullmann coupling oxazolidinone bromoiodoarene.

We describe the highly selective copper-catalyzed Ullmann-type coupling of bromoiodoarenes with oxazolidinones. 3,4,7,8-Tetramethyl-1,10-phenanthroline (Me4Phen) was identified as an optimal ligand promoting the desired C-N bond formation, while minimizing the competitive bromo-iodo exchange pathway that leads to formation of iodo-substituted and bis-coupled side products. The developed method is highly selective with a >98:2 ratio of the bromo- vs. iodo-substituted compounds obtained in the isolated products.

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Jouvin, Kevin’s team published research in Organometallics in 2012-11-26 | CAS: 4042-43-7

Organometallics published new progress about Alkynylation. 4042-43-7 belongs to class oxazolidine, name is (R)-4-Methyloxazolidin-2-one, and the molecular formula is C4H7NO2, Recommanded Product: (R)-4-Methyloxazolidin-2-one.

Jouvin, Kevin published the artcileCopper-Mediated Selective Cross-Coupling of 1,1-Dibromo-1-alkenes and Heteronucleophiles: Development of General Routes to Heterosubstituted Alkynes and Alkenes, Recommanded Product: (R)-4-Methyloxazolidin-2-one, the main research area is dibromoalkene nitrogen phosphorus oxygen heteronucleophile cross coupling copper catalyst; site selective double alkynylative cross coupling copper catalyst dibromoalkene; bromoenamide ynamide ketene acetal bromoenol ynol ether vinylphosphonate preparation.

Efficient and general procedures for the cross-coupling of 1,1-dibromoalkenes and N-, O-, and P-nucleophiles are reported. Fine-tuning of the reaction conditions allows for either site-selective, double, or alkynylative cross-coupling, therefore providing divergent and straightforward entries to numerous building blocks such as bromoenamides, ynamides, ketene N,N-acetals, bromoenol ethers, ynol ethers, ketene O,O-acetals, or vinylphosphonates and further expanding the copper catalysis toolbox with useful and versatile processes.

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Liu, Li-Juan et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2017 | CAS: 135948-04-8

(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. In another report, the incorporation of an additional substituted oxazolidine ring over a range of new biphenylazepinium salt organocatalysts for the asymmetric epoxidation of alkenes improved enantiocontrol over the parent structures.Recommanded Product: (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol

Correction: Inhibition of TLR1/2 dimerization by enantiomers of metal complexes [Erratum to document cited in CA165:458094] was written by Liu, Li-Juan; Wang, Wanhe; Zhong, Zhangfeng; Lin, Sheng; Lu, Lihua; Wang, Yi-Tao; Ma, Dik-Lung; Leung, Chung-Hang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Recommanded Product: (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the article:

Correction for ′Inhibition of TLR1/2 dimerization by enantiomers of metal complexes′ by Li-Juan Liu et al., Chem. Commun., 2016, 52, 12278-12281. This study involved multiple reactions and reactants, such as (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8Recommanded Product: (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol).

135948-04-8;(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 135948-04-8;New trend of C13H17NO2;function of 135948-04-8

Liu, Li-Juan et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2017 | CAS: 150699-10-8

(R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-10-8) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.Computed Properties of C13H17NO2

Correction: Inhibition of TLR1/2 dimerization by enantiomers of metal complexes [Erratum to document cited in CA165:458094] was written by Liu, Li-Juan; Wang, Wanhe; Zhong, Zhangfeng; Lin, Sheng; Lu, Lihua; Wang, Yi-Tao; Ma, Dik-Lung; Leung, Chung-Hang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Computed Properties of C13H17NO2 The following contents are mentioned in the article:

Correction for ′Inhibition of TLR1/2 dimerization by enantiomers of metal complexes′ by Li-Juan Liu et al., Chem. Commun., 2016, 52, 12278-12281. This study involved multiple reactions and reactants, such as (R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-10-8Computed Properties of C13H17NO2).

150699-10-8;(R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 150699-10-8;New trend of C13H17NO2;function of 150699-10-8

Liu, Li-Juan et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2016 | CAS: 150699-10-8

(R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-10-8) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Related Products of 150699-10-8

Inhibition of TLR1/2 dimerization by enantiomers of metal complexes was written by Liu, Li-Juan; Wang, Wanhe; Zhong, Zhangfeng; Lin, Sheng; Lu, Lihua; Wang, Yi-Tao; Ma, Dik-Lung; Leung, Chung-Hang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.Related Products of 150699-10-8 The following contents are mentioned in the article:

The authors report herein the identification of an immunomodulatory metal-based complex 1 as a direct inhibitor of TLR1/2 heterodimerization. Both enantiomers of complex 1 selectively suppressed TNF-α and TLR1/2 heterodimerization in Pam3CSK4-induced macrophages, with Λ-1 being more potent than Δ-1. Moreover, the complexes inhibited NF-κB transduction via the modulation of TLR1/2 signaling. To the knowledge, complex 1 is the first metal-based inhibitor of TLR1/2 heterodimerization reported to date. This study involved multiple reactions and reactants, such as (R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-10-8Related Products of 150699-10-8).

150699-10-8;(R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 150699-10-8;New trend of C13H17NO2;function of 150699-10-8

Liu, Li-Juan et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2016 | CAS: 135948-04-8

(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8) belongs to oxazolidine derivatives. A common way to produce multisubstituted oxazolidines is by means of cycloaddition reactions. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Related Products of 135948-04-8

Inhibition of TLR1/2 dimerization by enantiomers of metal complexes was written by Liu, Li-Juan; Wang, Wanhe; Zhong, Zhangfeng; Lin, Sheng; Lu, Lihua; Wang, Yi-Tao; Ma, Dik-Lung; Leung, Chung-Hang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.Related Products of 135948-04-8 The following contents are mentioned in the article:

The authors report herein the identification of an immunomodulatory metal-based complex 1 as a direct inhibitor of TLR1/2 heterodimerization. Both enantiomers of complex 1 selectively suppressed TNF-α and TLR1/2 heterodimerization in Pam3CSK4-induced macrophages, with Λ-1 being more potent than Δ-1. Moreover, the complexes inhibited NF-κB transduction via the modulation of TLR1/2 signaling. To the knowledge, complex 1 is the first metal-based inhibitor of TLR1/2 heterodimerization reported to date. This study involved multiple reactions and reactants, such as (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8Related Products of 135948-04-8).

135948-04-8;(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 135948-04-8;New trend of C13H17NO2;function of 135948-04-8

Aitken, R. Alan et al. published their research in Molecules in 2022 | CAS: 163165-92-2

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.Computed Properties of C16H15NO2

Further Studies on the [1,2]-Wittig Rearrangement of 2-(2-Benzyloxy)aryloxazolines was written by Aitken, R. Alan; Harper, Andrew D.; Inwood, Ryan A.. And the article was included in Molecules in 2022.Computed Properties of C16H15NO2 The following contents are mentioned in the article:

The behavior of 14 ortho-functionalized 2-aryloxazolines (11 of them prepared and characterized for the first time) with butyllithium had been examined Significant limitations to the Wittig rearrangement of such systems were revealed. In terms of asym. Wittig rearrangement, good diastereoselectivity was obtained with a valine-derived 4-iso-Pr oxazoline, but this was compromised by racemization upon hydrolysis. More encouraging selectivity was achieved in the Wittig rearrangement of an acyclic phenylalanine-derived ortho-benzyloxy benzamide. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Computed Properties of C16H15NO2).

163165-92-2;(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-92-2;New trend of C16H15NO2;function of 163165-92-2

Aitken, R. Alan et al. published their research in Molecules in 2022 | CAS: 150699-08-4

(R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.Formula: C15H13NO2

Further Studies on the [1,2]-Wittig Rearrangement of 2-(2-Benzyloxy)aryloxazolines was written by Aitken, R. Alan; Harper, Andrew D.; Inwood, Ryan A.. And the article was included in Molecules in 2022.Formula: C15H13NO2 The following contents are mentioned in the article:

The behavior of 14 ortho-functionalized 2-aryloxazolines (11 of them prepared and characterized for the first time) with butyllithium had been examined Significant limitations to the Wittig rearrangement of such systems were revealed. In terms of asym. Wittig rearrangement, good diastereoselectivity was obtained with a valine-derived 4-iso-Pr oxazoline, but this was compromised by racemization upon hydrolysis. More encouraging selectivity was achieved in the Wittig rearrangement of an acyclic phenylalanine-derived ortho-benzyloxy benzamide. This study involved multiple reactions and reactants, such as (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4Formula: C15H13NO2).

150699-08-4;(R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol;The future of 150699-08-4;New trend of C15H13NO2;function of 150699-08-4

Goebel, Peter et al. published their research in European Journal of Inorganic Chemistry in 2015 | CAS: 135948-04-8

(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Computed Properties of C13H17NO2

Probing Chiral Recognition of Enzyme Active Sites with Octahedral Iridium(III) Propeller Complexes was written by Goebel, Peter; Ritterbusch, Florian; Helms, Melanie; Bischof, Matthias; Harms, Klaus; Jung, Manfred; Meggers, Eric. And the article was included in European Journal of Inorganic Chemistry in 2015.Computed Properties of C13H17NO2 The following contents are mentioned in the article:

Chiral bis-cyclometalated octahedral organoiridium(III) complexes were designed to target different classes of enzymes, namely carbonic anhydrases, histone deacetylases, and serine proteases. The stereoselective non-racemic synthesis of selected complexes was used to study the chiral discrimination of enzyme active sites for enantiomers of propeller-type octahedral metal complexes. Cases for negligible, modest, and significant chiral discrimination in the interaction of iridium propeller complexes with enzyme active sites were identified. This study involved multiple reactions and reactants, such as (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8Computed Properties of C13H17NO2).

(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Computed Properties of C13H17NO2

135948-04-8;(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 135948-04-8;New trend of C13H17NO2;function of 135948-04-8