Day: November 9, 2022

Cobalt/Salox-Catalyzed Enantioselective C-H Functionalization of Arylphosphinamides was written by Yao, Qi-Jun; Chen, Jia-Hao; Song, Hong; Huang, Fan-Rui; Shi, Bing-Feng. And the article was included in Angewandte Chemie, International Edition on June 20,2022.Synthetic Route of C13H17NO2 The following contents are mentioned in the article:

Previous methods on Co(III)-catalyzed asym. C-H activation rely on the use of tailor-made cyclopentadienyl-ligated Co(III) complexes, which require lengthy steps for the preparation Herein, the authors report an unprecedented enantioselective C-H functionalization enabled by a simple Co/salicyloxazoline (Salox) catalysis. The chiral Salox ligands can be easily prepared in one step from salicylonitrile and chiral amino alcs. A broad range of P-stereogenic compounds were synthesized in high yields with excellent enantioselectivities (45 examples, up to 99% yield and >99% ee). The isolation and characterization of several intermediates provided insights into the generation of active catalytic Co species, the action of Salox, and the mode of stereocontrol. This study involved multiple reactions and reactants, such as (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8Synthetic Route of C13H17NO2).

(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Synthetic Route of C13H17NO2

135948-04-8;(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 135948-04-8;New trend of C13H17NO2;function of 135948-04-8

Chiral-at-Iron Catalyst for Highly Enantioselective and Diastereoselective Hetero-Diels-Alder Reaction was written by Hong, Yubiao; Cui, Tianjiao; Ivlev, Sergei; Xie, Xiulan; Meggers, Eric. And the article was included in Chemistry – A European Journal on June 10,2021.Formula: C12H15NO2 The following contents are mentioned in the article:

This study demonstrates that chiral-at-iron complexes, in which all coordinated ligands are achiral and the overall chirality the consequence of a stereogenic iron center, are capable of catalyzing asym. transformations with very high enantioselectivities. The catalyst is based on a previously reported design (J. Am. Chem. Soc. 2017, 139, 4322), in which iron(II) is surrounded by two configurationally inert achiral bidentate N-(2-pyridyl)-substituted N-heterocyclic carbenes in a C2-sym. fashion and complemented by two labile acetonitriles. By replacing mesityl with more bulky 2,6-diisopropylphenyl substituents at the NHC ligands, the steric hindrance at the catalytic site was increased, thereby providing a markedly improved asym. induction. The new chiral-at-iron catalyst was applied to the inverse electron demand hetero-Diels-Alder reaction between β,γ-unsaturated α-ketoester and enol ethers provide 3,4-dihydro-2H-pyrans in high yields with excellent diastereoselectivities (up to 99 : 1 dr) and excellent enantioselectivities (up to 98% ee). Other electron rich dienophiles are also suitable as demonstrated for a reaction with a vinyl azide. This study involved multiple reactions and reactants, such as (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6Formula: C12H15NO2).

(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Formula: C12H15NO2

1045894-43-6;(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol;The future of 1045894-43-6;New trend of C12H15NO2;function of 1045894-43-6

Remarkable reversal of the non-linear effect in the catalytic enantioselective allylic oxidation of cyclohexene using copper proline complexes and t-butyl hydroperoxide was written by Zondervan, Charon; Feringa, Ben L.. And the article was included in Tetrahedron: Asymmetry on July 12,1996.Product Details of 163165-92-2 The following contents are mentioned in the article:

Several examples of efficient catalytic conversions of cyclohexene to optically active 2-cyclohexenyl propionate are reported using t-Bu hydroperoxide as oxidant. With the bis-(S)-prolinato copper(II) complex enantioselectivities up to 63% with good conversions were obtained. A neg. non-linear ligand effect was observed Addition of catalytic amounts of anthraquinone resulted in a higher enantioselectivity as well as a reversal of the non-linear effect. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Product Details of 163165-92-2).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. In another report, the incorporation of an additional substituted oxazolidine ring over a range of new biphenylazepinium salt organocatalysts for the asymmetric epoxidation of alkenes improved enantiocontrol over the parent structures.Product Details of 163165-92-2

163165-92-2;(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-92-2;New trend of C16H15NO2;function of 163165-92-2

Aerobic C(sp2)-H Hydroxylations of 2-Aryloxazolines: Fast Access to Excited-State Intramolecular Proton Transfer (ESIPT)-Based Luminophores was written by Goebel, Dominik; Clamor, Nils; Lork, Enno; Nachtsheim, Boris J.. And the article was included in Organic Letters on July 19,2019.Category: oxazolidine The following contents are mentioned in the article:

The direct hydroxylation of 2-aryloxazolines via a deprotonative magnesiation using TMPMgCl·LiCl and subsequent oxidation with mol. oxygen or air as a green oxidant is reported. This method proceeds under mild conditions at room temperature with high regioselectivity and chemoselectivity. The obtained phenols exhibit tunable luminescence properties, induced by excited-state intramol. proton transfer. This method opens a new opportunity for the sustainable synthesis of luminescent organic mols. This study involved multiple reactions and reactants, such as 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1Category: oxazolidine).

2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.Category: oxazolidine

163165-91-1;2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-91-1;New trend of C11H13NO2;function of 163165-91-1

Chiral-Auxiliary-Mediated Asymmetric Synthesis of Tris-Heteroleptic Ruthenium Polypyridyl Complexes was written by Gong, Lei; Mulcahy, Seann P.; Harms, Klaus; Meggers, Eric. And the article was included in Journal of the American Chemical Society on July 22,2009.Related Products of 1045894-43-6 The following contents are mentioned in the article:

A strategy for the asym. synthesis of chiral-at-metal [Ru(pp)(pp’)(pp”)]+ complexes (Hpp = isopropyl-2-(2′-hydroxyphenyl)oxazoline, pp’ and pp” = achiral 2,2′-bipyridine, 5,5′-dimethyl- and 4,4′-di-tert-butyl-2,2′-bipyridine), is reported. The method employs isopropyl-2-(2′-hydroxyphenyl)oxazolines as chiral auxiliaries, which serve in their deprotonated forms as strong bidentate ligands that provide excellent asym. induction in the coordination chem. and, importantly, can afterward become substituted with complete retention of configuration in the presence of acid. This study involved multiple reactions and reactants, such as (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6Related Products of 1045894-43-6).

(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Related Products of 1045894-43-6

1045894-43-6;(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol;The future of 1045894-43-6;New trend of C12H15NO2;function of 1045894-43-6

Chiral Pd-, Cu- and Ni-chelates and their utilities as catalysts in allylic acetoxylation of alkenes was written by Yang, Hu; Khan, Masood A.; Nicholas, Kenneth M.. And the article was included in Journal of Molecular Catalysis on July 29,1994.Quality Control of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the article:

A series of chiral ML*2 complexes of Pd, Cu and Ni [L = 2-trifluoroacetylcamphorato (tfacam), (R)-N-α-methylbenzylsalicylaldimine, 2-(2′-phenolato)-4-substituted oxazoline (phenox)] were prepared and characterized, including x-ray structures of Pd(tfacam)2 (1) and Pd(4-Ph-phenox)2 (3a). The Pd- and Cu-chelates are active (pre)catalysts for the allylic acetoxylation of alkenes. The yields and chemoselectivities in these reactions are high but little enantioselectivity (0-5%) was found. Several mechanistic probes, including tests of the stability of the product and PdL*2 under the reaction conditions, the product distribution from the acetoxylation of D-1-cyclohexene, and the low acetolysis reactivity of LPd(η3-allyl), indicate the intervention of (η3-allyl)-Pd intermediates in the catalytic process in which either or both L groups dissociate or at least dechelate in the product-forming step. This study involved multiple reactions and reactants, such as (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4Quality Control of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol).

(R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.Quality Control of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol

150699-08-4;(R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol;The future of 150699-08-4;New trend of C15H13NO2;function of 150699-08-4

Chiral Pd-, Cu- and Ni-chelates and their utilities as catalysts in allylic acetoxylation of alkenes was written by Yang, Hu; Khan, Masood A.; Nicholas, Kenneth M.. And the article was included in Journal of Molecular Catalysis on July 29,1994.Related Products of 150699-10-8 The following contents are mentioned in the article:

A series of chiral ML*2 complexes of Pd, Cu and Ni [L = 2-trifluoroacetylcamphorato (tfacam), (R)-N-α-methylbenzylsalicylaldimine, 2-(2′-phenolato)-4-substituted oxazoline (phenox)] were prepared and characterized, including x-ray structures of Pd(tfacam)2 (1) and Pd(4-Ph-phenox)2 (3a). The Pd- and Cu-chelates are active (pre)catalysts for the allylic acetoxylation of alkenes. The yields and chemoselectivities in these reactions are high but little enantioselectivity (0-5%) was found. Several mechanistic probes, including tests of the stability of the product and PdL*2 under the reaction conditions, the product distribution from the acetoxylation of D-1-cyclohexene, and the low acetolysis reactivity of LPd(η3-allyl), indicate the intervention of (η3-allyl)-Pd intermediates in the catalytic process in which either or both L groups dissociate or at least dechelate in the product-forming step. This study involved multiple reactions and reactants, such as (R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-10-8Related Products of 150699-10-8).

(R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-10-8) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. In another report, the incorporation of an additional substituted oxazolidine ring over a range of new biphenylazepinium salt organocatalysts for the asymmetric epoxidation of alkenes improved enantiocontrol over the parent structures.Related Products of 150699-10-8

150699-10-8;(R)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 150699-10-8;New trend of C13H17NO2;function of 150699-10-8

Synthesis of chiral aryloxazoline hydroaluminum and its asymmetric reduction for ketones was written by Wu, Hai-Chen; Xu, Dong-Cheng; Hua, Wen-Ting. And the article was included in Huaxue Xuebao on August 31,2001.Reference of 163165-92-2 The following contents are mentioned in the article:

Title compounds I (R = (CH3)2CHCH2, (CH3)2CH, C6H5CH2) as chiral ligands, were prepared A new type of title compounds I modified lithium aluminum hydride reducing agents (DIOAL-H) were prepared, which exhibited moderate enantioselectivity in the reduction of different ketones, R2COCH3 (R2 = C6H5, 2-naphthyl, CH3(CH2)3). This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Reference of 163165-92-2).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Reference of 163165-92-2

163165-92-2;(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-92-2;New trend of C16H15NO2;function of 163165-92-2

PHOX-Based Phosphite-Oxazoline Ligands for the Enantioselective Ir-Catalyzed Hydrogenation of Cyclic β-Enamides was written by Magre, Marc; Pamies, Oscar; Dieguez, Montserrat. And the article was included in ACS Catalysis on August 5,2016.Recommanded Product: (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the article:

Simple Ir-PHOX-based phosphite-oxazoline catalysts were successfully applied in the asym. hydrogenation of cyclic β-enamides providing better enantioselectivities than previous effective Ru and Rh catalysts. This protocol gave 2-aminotetralines and 3-aminochromanes, key structural units found in many therapeutic agents and biol. active natural products, in high chem. yields and enantioselectivities (ee’s up to 99%). High enantioselectivities also were achieved in the hydrogenation of cyclic α-enamides. This study involved multiple reactions and reactants, such as (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8Recommanded Product: (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol).

(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.Recommanded Product: (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol

135948-04-8;(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 135948-04-8;New trend of C13H17NO2;function of 135948-04-8

Asymmetric Nucleophilic Catalysis with an Octahedral Chiral-at-Metal Iridium(III) Complex was written by Cruchter, Thomas; Medvedev, Michael G.; Shen, Xiaodong; Mietke, Thomas; Harms, Klaus; Marsch, Michael; Meggers, Eric. And the article was included in ACS Catalysis on August 4,2017.Computed Properties of C13H17NO2 The following contents are mentioned in the article:

Herein, we report about the design, synthesis, and application of a nucleophilic octahedral chiral-only-at-metal iridium(III) complex. We demonstrate that the enantiopure form of this complex serves as an efficient catalyst for the asym. Steglich rearrangement of O-acylated azlactones (up to 96% ee and 99% yield) and the related asym. Black rearrangement of O-acylated benzofuranones (up to 94% ee and 99% yield). We provide insight into the mechanisms of these two acyl migration reactions and the catalyst’s manner of chiral recognition with crystal structures of the active catalyst and a catalysis intermediate analog, as well as with quantum chem. calculations based on them. Furthermore, we demonstrate that the presented catalyst also efficiently catalyzes the asym. reaction between aryl alkyl ketenes and 2-cyanopyrrole to give the corresponding α-chiral N-acyl pyrroles (up to 95% ee and 99% yield). This study involved multiple reactions and reactants, such as (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8Computed Properties of C13H17NO2).

(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8) belongs to oxazolidine derivatives. A common way to produce multisubstituted oxazolidines is by means of cycloaddition reactions. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.Computed Properties of C13H17NO2

135948-04-8;(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 135948-04-8;New trend of C13H17NO2;function of 135948-04-8