Final Thoughts on Chemistry for 67914-60-7

This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Computed Properties of C12H16N2O2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Jiang, Jie; Seel, Catharina Julia; Temirak, Ahmed; Namasivayam, Vigneshwaran; Arridu, Antonella; Schabikowski, Jakub; Baqi, Younis; Hinz, Sonja; Hockemeyer, Joerg; Mueller, Christa E. published the article 《A2B Adenosine Receptor Antagonists with Picomolar Potency》. Keywords: A2B adenosine receptor antagonist benzenesulfonamide.They researched the compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone( cas:67914-60-7 ).Computed Properties of C12H16N2O2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:67914-60-7) here.

The A2B adenosine receptor (A2BAR) was proposed as a novel target for the (immuno)therapy of cancer since A2BAR blockade results in antiproliferative, anti-angiogenic, anti-metastatic, and immuno-stimulatory effects. In this study, we explored the structure-activity relationships of xanthin-8-yl-benzenesulfonamides mainly by introducing a variety of linkers and substituents attached to the sulfonamide residue. A new, convergent strategy was established which facilitated the synthesis of the target compounds Many of the new compounds exhibited subnanomolar affinity for the A2BAR combined with high selectivity. Functional groups were introduced which will allow the attachment of dyes and other reporter groups. 8-(4-((4-(4-Bromophenyl)piperazin-1-yl)sulfonyl)phenyl)-1-propylxanthine (34, PSB-1901) was the most potent A2B-antagonist (Ki 0.0835 nM, KB 0.0598 nM, human A2BAR) with >10,000-fold selectivity vs. all other AR subtypes. It was similarly potent and selective at the mouse A2BAR, making it a promising tool for preclin. studies. Computational studies predicted halogen bonding to contribute to the outstanding potency of 34.

This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Computed Properties of C12H16N2O2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Sources of common compounds: 70-23-5

This compound(Ethyl 3-bromo-2-oxopropanoate)Synthetic Route of C5H7BrO3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Synthetic Route of C5H7BrO3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about A Highly Selective “”Turn-On”” Fluorescent Sensor for Aluminum Ion Detection in Aqueous Solution Based on Imidazo[2,1-b]thiazole Schiff Base. Author is Wang, Haibin; Xu, Xin; Yin, Jichen; Zhang, Zhifeng; Xue, Lei.

Low sensitivity of fluorescent sensors with “”turn-off”” response for identifying Al3+ has limited their wide application in the field of ion sensing. Herein, this paper reports a novel fluorescence sensor (L) endowing with “”turn-on”” fluorescence response based on imidazo[2,1-b]thiazole for recognizing Al3+ in aqueous solutions Results show that the L exhibits high selectivity and sensitivity with “”turn-on”” fluorescence response towards Al3+, but also has strong anti-interference to other common ions. In addition, the excellent color change can be distinguished by naked eyes under UV light and the test papers show great potential for detecting Al3+ in tap water. The supposed sensing mechanism of L to Al3+ could be attributed to the inhibition of photo-induced electron transfer (PET) and chelation-enhanced fluorescence (CHEF). Such a novel design pathway is expected to offer helpful guidance for fabricating various sensors with “”turn-on””; fluorescence response.

This compound(Ethyl 3-bromo-2-oxopropanoate)Synthetic Route of C5H7BrO3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Extracurricular laboratory: Synthetic route of 7789-45-9

《High-temperature phase transition containing switchable dielectric behavior, long fluorescence lifetime, and distinct photoluminescence changes in 2D hybrid CuBr4 perovskite》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Cupric bromide)SDS of cas: 7789-45-9.

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 7789-45-9, is researched, SMILESS is [Cu+2].[Br-].[Br-], Molecular Br2CuJournal, Article, Inorganic Chemistry called High-temperature phase transition containing switchable dielectric behavior, long fluorescence lifetime, and distinct photoluminescence changes in 2D hybrid CuBr4 perovskite, Author is Han, Ding-Chong; Tan, Yu-Hui; Wu, Wei-Chao; Li, Yu-Kong; Tang, Yun-Zhi; Zhuang, Jia-Chang; Ying, Ting-Ting; Zhang, Hao, the main research direction is phase transition switchable dielec behavior fluorescence hybrid perovskite.SDS of cas: 7789-45-9.

A novel organic-inorganic hybrid perovskite crystal, [ClC6H4(CH2)2NH3]2CuBr4 (1), having experienced an invertible high-temperature phase transition near Tc (Curie temperature Tc = 355 K), has been successfully synthesized. The phase-transition characteristics for compound 1 are thoroughly revealed by sp. heat capacity (Cp), DTA, and differential scanning calorimetry tests, possessing 16 K broad thermal hysteresis. Multiple-temperature powder X-ray diffraction anal. further proves the phase-transition behavior of compound 1. Moreover, compound 1 exhibits a significant steplike dielec. response near Tc, revealing that it can be deemed to be a promising dielec. switching material. The variable-temperature fluorescence experiments show distinct photoluminescence (PL) changes of compound 1. Further investigation and calculation disclose that the fluorescence lifetime of compound 1 can reach as long as 55.46 μs, indicating that it can be a potential PL material. All of these researches contribute a substitutable avenue in the design and construction of neoteric phase-transition compounds combining high Curie temperature and PL properties.

《High-temperature phase transition containing switchable dielectric behavior, long fluorescence lifetime, and distinct photoluminescence changes in 2D hybrid CuBr4 perovskite》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Cupric bromide)SDS of cas: 7789-45-9.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

A new application about 67914-60-7

《Substituted phthalocyanines and their electropolymerization properties》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Formula: C12H16N2O2.

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Substituted phthalocyanines and their electropolymerization properties, published in 2016-10-31, which mentions a compound: 67914-60-7, Name is 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, Molecular C12H16N2O2, Formula: C12H16N2O2.

New metal-free and metallo-phthalocyanine complexes (Co, TiO) were synthesized using a piperazine-substituted phthalonitrile derivative All proposed structures were supported by instrumental methods. Electrochem. studies of H2-Pc, TiIVOPc, and CoIIPc were examined using cyclic voltammetry (CV) and square-wave voltammetry (SWV) techniques. Voltammetric analyses of phthalocyanines supported the proposed structure of the synthesized complexes. All studied phthalocyanines were oxidatively electropolymerized on the working electrode during the repetitive anodic potential scans.

《Substituted phthalocyanines and their electropolymerization properties》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Formula: C12H16N2O2.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

The effect of reaction temperature change on equilibrium 5451-40-1

《Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,6-Dichloropurine)Safety of 2,6-Dichloropurine.

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 5451-40-1, is researched, Molecular C5H2Cl2N4, about Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines, the main research direction is benzenesulfonyl fused azolylbenzoxazepine preparation; HER2 inhibition antitumor SAR pyroptosis induction docking; Antitumour; HER2 receptor; benzoxazepines; molecular modelling; pyroptosis.Safety of 2,6-Dichloropurine.

A series of 11 new substituted 1,5-dihydro-4,1-benzoxazepine derivatives I [X = Y = Z = CH, N; R = H, Cl, Me2N, etc.; R1 = H, Cl; R2 = 4-Me, 4-O2N, 4-O2N] were synthesized to study the influence of the Me group in the 1-(benzenesulfonyl) moiety, the replacement of the purine by the benzotriazole bioisosteric analog, and the introduction of a bulky substituent at position 6 of the purine, on the biol. effects. Their inhibition against isolated HER2 was studied and the structure-activity relationships were confirmed by mol. modeling studies. The most potent compound against isolated HER2 was I [X = Y = N, Z = CH, R = C6H5S, R1 = Cl, R2 = 4-O2N] with an IC50 of 7.31μM. The effects of the target compounds on cell proliferation was investigated. The most active compound was I [X = Y = N, Z = CH, R = R1 = Cl, R2 = 4-Me] against all the tumor cell lines studied (IC50 0.42-0.86μM) does not produce any modification in the expression of pro-caspase 3, but increased the caspase 1 expression and promoted pyroptosis.

《Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,6-Dichloropurine)Safety of 2,6-Dichloropurine.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Some scientific research about 1194-22-5

《Effect of pyrimidine derivatives on the incorporation of labeled amino acids into liver proteins》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Electric Literature of C5H6N2O2.

Electric Literature of C5H6N2O2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Effect of pyrimidine derivatives on the incorporation of labeled amino acids into liver proteins. Author is Lifshits, R. I.; Kamilov, F. Kh..

Uracil [66-22-8], cytosine [71-30-7], 6-hydroxy-2,4-dimethylpyrimidine [6622-92-0], 4,6-dihydroxy-2-methylpyrimidine [1194-22-5], 2-amino-6-hydroxy-4-methylpyrimidine [3977-29-5], or 2,5-diamino-6-hydroxy-4-methylpyrimidine [4214-86-2] increased 14C-labeled alanine [56-41-7] incorporation into proteins of the mitochondria-free liver cell fraction when injected i.p. at 100 mg/kg into rats, added at 0.6 mM to the perfusion liquid of the isolated rat liver, or incubated at 0.6 mM with the liver tissue. Orotic acid [65-86-1] had no effect on the liver protein synthesis. The pyrimidine derivatives might affect enzyme synthesis by stimulating DNA-dependent RNA synthesis.

《Effect of pyrimidine derivatives on the incorporation of labeled amino acids into liver proteins》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Electric Literature of C5H6N2O2.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Decrypt The Mystery Of 1194-22-5

《Near-infrared electrophotographic photoreceptor incorporating a hydroxy squaraine》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Application of 1194-22-5.

Application of 1194-22-5. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Near-infrared electrophotographic photoreceptor incorporating a hydroxy squaraine. Author is DiPaola-Baranyi, G.; Hsiao, C. K.; Kazmaier, P. M.; Burt, R.; Loutfy, R. O.; Martin, T. I..

The synthesis and xerog. evaluation of bis(4-dimethylamino-2-hydroxy-6-methylphenyl)squaraine (I) is described. Significant photosensitivity enhancement is observed upon addition of certain phenols during the synthesis of the squaraine. Neg. charged dual layer photoreceptor devices incorporating doped I are characterized by excellent xerog. properties such as low dark decay (<50 V/s), high white light and IR sensitivity (E1/2 ≃ 5 ergs/cm2 at 830 nm) and good short-term cycling stability. The effect of charge generator layer thickness, pigment loading and nature of the polymer binder are discussed. 《Near-infrared electrophotographic photoreceptor incorporating a hydroxy squaraine》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Application of 1194-22-5.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Sources of common compounds: 5451-40-1

《An AIE-Based Probe for Rapid and Ultrasensitive Imaging of Plasma Membranes in Biosystems》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,6-Dichloropurine)COA of Formula: C5H2Cl2N4.

Shi, Lei; Liu, Yan-Hong; Li, Kun; Sharma, Amit; Yu, Kang-Kang; Ji, Myung Sun; Li, Ling-Ling; Zhou, Qian; Zhang, Hong; Kim, Jong Seung; Yu, Xiao-Qi published an article about the compound: 2,6-Dichloropurine( cas:5451-40-1,SMILESS:C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2 ).COA of Formula: C5H2Cl2N4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:5451-40-1) through the article.

The abnormality of the plasma membrane (PM) is an important biomarker for cell status and many diseases. Hence, visualizing the PM, especially in complex systems, is an emerging field in the life sciences, especially in low-resource settings. Herein, we developed a water-soluble PM-specific probe utilizing electrostatic and hydrophobic interaction strategies with aggregation-induced emission as the signal output. The probe could image the PM with many advanced features (wash-free, ultrafast staining process, excellent PM specificity, and good biocompatibility), which were demonstrated by the PM imaging of neurons. The probe allowed for the first time the imaging of erythrocytes in the complex brain environment through a fluorescence-based method. Moreover, the PM of the epidermal and partial view of the eyeball structure of live zebrafish are also revealed.

《An AIE-Based Probe for Rapid and Ultrasensitive Imaging of Plasma Membranes in Biosystems》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,6-Dichloropurine)COA of Formula: C5H2Cl2N4.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Derivation of elementary reaction about 1194-22-5

《The proton magnetic resonance spectra and the structure of 4,6-dihydroxypyrimidine and its derivatives》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)HPLC of Formula: 1194-22-5.

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1194-22-5, is researched, Molecular C5H6N2O2, about The proton magnetic resonance spectra and the structure of 4,6-dihydroxypyrimidine and its derivatives, the main research direction is DIHYDROXYPYRIMIDINES PMR; PYRIMIDINES PMR; HYDROXYPYRIMIDINES PMR.HPLC of Formula: 1194-22-5.

The proton N.M.R. spectra of 4,6-dihydroxypyrimidine and its 2- and 5-substituted derivatives have been compared with the spectra of their O- and N-methyl derivatives of fixed structures, corresponding to possible tautomeric forms. In a Me2SO medium the compounds exist predominantly in the oxohydroxy form. In aqueous solutions of 4,6-dihydroxypyrimidine and its N-methyl derivatives the bipolar-ionic form with delocalized charges probably predominates. 22 references.

《The proton magnetic resonance spectra and the structure of 4,6-dihydroxypyrimidine and its derivatives》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)HPLC of Formula: 1194-22-5.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Archives for Chemistry Experiments of 288-42-6

《Ah receptor ligands and their impacts on gut resilience: structure-activity effects》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Oxazole)Application In Synthesis of Oxazole.

Application In Synthesis of Oxazole. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Oxazole, is researched, Molecular C3H3NO, CAS is 288-42-6, about Ah receptor ligands and their impacts on gut resilience: structure-activity effects. Author is Safe, Stephen; Jayaraman, Arul; Chapkin, Robert S..

A review. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and structurally related halogenated aromatics modulate gene expression and induce biochem. and toxic responses that are mediated by initial binding to the aryl hydrocarbon receptor (AhR). The AhR also binds structurally diverse compound including pharmaceuticals, endogenous biochems., health-promoting phytochems., and microbial metabolites. Many of these AhR ligands do not induce TCDD-like toxic responses and some AhR ligands such as microbial metabolites of tryptophan play a role in maintaining gut health and protecting against intestinal inflammation and cancer. Many AhR ligands exhibit tissue- and response-specific AhR agonist or antagonist activities, and act as selective AhR modulators (SAhRMs) and this SAhRM-like activity has also been observed in AhR-ligand-mediated effects in the intestine. This review summarizes studies showing that several AhR ligands including phytochems. and TCDD protect against dextran sodium sulfate-induced intestinal inflammation. In contrast, AhR ligands such as oxazole compounds enhance intestinal inflammation suggesting that AhR-mediated gut health can be enhanced or decreased by selective AhR modulators and this needs to be considered in development of AhR ligands for therapeutic applications in treating intestinal inflammation.

《Ah receptor ligands and their impacts on gut resilience: structure-activity effects》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Oxazole)Application In Synthesis of Oxazole.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem