Now Is The Time For You To Know The Truth About 67914-60-7

The article 《Synthesis of ketoconazole by phase-transfer catalysis》 also mentions many details about this compound(67914-60-7)SDS of cas: 67914-60-7, you can pay attention to it, because details determine success or failure

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 67914-60-7, is researched, Molecular C12H16N2O2, about Synthesis of ketoconazole by phase-transfer catalysis, the main research direction is ketoconazole synthesis antifungal drug bromomethyldichlorophenyl dioxolanylmethanol.SDS of cas: 67914-60-7.

Antifungal drug ketoconazole was synthesized by utilization of phase-transfer catalysis from [2-bromomethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methanol via acylation, N-alkylation with imidazole and hydrolysis, formation the active ester with methanesulfonyl chloride, and then condensation with the side chain 1-acetyl-4-(4-hydroxyphenyl)piperazine. The overall yield was about 30%.

The article 《Synthesis of ketoconazole by phase-transfer catalysis》 also mentions many details about this compound(67914-60-7)SDS of cas: 67914-60-7, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Discover the magic of the 1194-22-5

The article 《Solution-Phase Synthesis of a Library of 3,5,7-Trisubstituted 3H-[1,2,3]triazolo[4,5-d]pyrimidines》 also mentions many details about this compound(1194-22-5)SDS of cas: 1194-22-5, you can pay attention to it, because details determine success or failure

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Solution-Phase Synthesis of a Library of 3,5,7-Trisubstituted 3H-[1,2,3]triazolo[4,5-d]pyrimidines, published in 2003-10-31, which mentions a compound: 1194-22-5, Name is 6-Hydroxy-2-methylpyrimidin-4(3H)-one, Molecular C5H6N2O2, SDS of cas: 1194-22-5.

An efficient solution-phase parallel synthesis of a library of 3,5,7-trisubstituted [1,2,3]triazolo[4,5-d]pyrimidines I [R1 = H, Me; R2 = Ph, PhCH2, 4-ClC6H4, 4-MeC6H4, 4-MeOC6H4; R3 = H, R4 = HOCH2CH2, cyclohexyl, Ph, PhCH2, PhNH, PhCH2O, etc.; R3R4 = (CH2)2N(CO2CMe3)(CH2)2] is described. 5-Amino-4,6-dichloropyrimidines II, prepared from monosubstituted amidines in four steps, reacted with primary amines R2NH2 to yield, after the following diazotization/intramol. cyclization, the 7-chloro-3,5-disubstituted [1,2,3]triazolo[4,5-d]pyrimidines III as penultimate intermediates. Final nucleophilic substitution of the 7-chloro group in III with an excess of a primary or secondary amine, a hydrazine or a O-alkyl hydroxylamine proceeds efficiently. Scavenging of the excess amine with a resin-bound isocyanate in the presence of resin-bound piperidine as a base afforded the desired 3,5,7-trisubstituted [1,2,3]triazolo[4,5-d]pyrimidines I in good yields and purities.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Discovery of 5451-40-1

The article 《Synthesis and anticancer activity of N-9- and N-7- substituted 1,2,3 triazole analogues of 2,6-di-substituted purine》 also mentions many details about this compound(5451-40-1)Safety of 2,6-Dichloropurine, you can pay attention to it, because details determine success or failure

Safety of 2,6-Dichloropurine. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Synthesis and anticancer activity of N-9- and N-7- substituted 1,2,3 triazole analogues of 2,6-di-substituted purine.

A library of N-9- and N-7-substituted 1,2,3 triazole analogs I [R1 = 2-hydroxyethylamino, benzylamino; R2 = pyrrolidin-1-yl, 1-piperidyl; R3 = H, 4-F, 2-Cl, etc.] and II [R4 = benzylamino; R5 = pyrrolidin-1-yl, 1-piperidyl; R6 = 4-MeO, 4-Br, 4-I] were generated on the 2,6-di-substituted purine upon reaction with various substituted aromatic azides. The synthesized analogs I and II were screened for in-vitro cytotoxic activity against various human cancer cell lines like (HCT-1 (colon), THP-1 (leukemia), IMR-32 (neuroblastoma) and A-549 (lung)). From the bioassay results, it was observed that even though most of the synthesized derivatives I and II exhibited a good potency against various screened cancer cell lines, but few of the analogs like I [R1 = benzylamino; R2 = pyrrolidin-1-yl, 1-piperidyl; R3 = H] and compound I [R1 = benzylamino; R2 = pyrrolidin-1-yl, R3 = 4-Cl] were found to be the most potent analogs in the series, with compound I [R1 = benzylamino, R2 = pyrrolidin-1-yl, R3 = H] showing IC50 values of 0.08 and 0.4 μM against THP-1 and A-549 cell lines, resp.

The article 《Synthesis and anticancer activity of N-9- and N-7- substituted 1,2,3 triazole analogues of 2,6-di-substituted purine》 also mentions many details about this compound(5451-40-1)Safety of 2,6-Dichloropurine, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Some scientific research about 288-42-6

The article 《Towards NIR-Active Hydroxybenzazole (HBX)-Based ESIPT Motifs: A Recent Research Trend》 also mentions many details about this compound(288-42-6)Recommanded Product: Oxazole, you can pay attention to it, because details determine success or failure

Recommanded Product: Oxazole. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Oxazole, is researched, Molecular C3H3NO, CAS is 288-42-6, about Towards NIR-Active Hydroxybenzazole (HBX)-Based ESIPT Motifs: A Recent Research Trend. Author is Mishra, Virendra R.; Ghanavatkar, Chaitannya W.; Sekar, Nagaiyan.

A review. In this review, we have explored the synthetic strategies adopted for designing the hydroxybenzazoles (imidazole, oxazole, and thiazole) i. e. HBX derivatives which show emission in red and NIR region. Further, we have examined the effect of different substituents i. e. either directly attached or with extended conjugation on a phenolic ring/Ph ring of heterocycles to achieve a red to NIR shift in emission. Finally, we have investigated the applications and computational methodologies adopted for red to NIR emitting dyes. In the future, this review will help to design, synthesized and examine the applications of new derivatives of HBX which will show emission in red to NIR region.

The article 《Towards NIR-Active Hydroxybenzazole (HBX)-Based ESIPT Motifs: A Recent Research Trend》 also mentions many details about this compound(288-42-6)Recommanded Product: Oxazole, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Machine Learning in Chemistry about 67914-60-7

The article 《Electrochemical oxidation of 4-(piperazin-1-yl)phenols in the presence of indole derivatives: The unique regioselectivity in the synthesis of highly conjugated bisindolyl-p-quinone derivatives》 also mentions many details about this compound(67914-60-7)Application In Synthesis of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, you can pay attention to it, because details determine success or failure

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Amani, Amene; Khazalpour, Sadegh; Nematollahi, Davood researched the compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone( cas:67914-60-7 ).Application In Synthesis of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone.They published the article 《Electrochemical oxidation of 4-(piperazin-1-yl)phenols in the presence of indole derivatives: The unique regioselectivity in the synthesis of highly conjugated bisindolyl-p-quinone derivatives》 about this compound( cas:67914-60-7 ) in Journal of Electroanalytical Chemistry. Keywords: electrooxidation piperazinylphenol indole derivative regioselectivity electrosynthesis conjugated bisindolyl quinone. We’ll tell you more about this compound (cas:67914-60-7).

The electrochem. oxidation of 4-(piperazin-1-yl)phenols were studied in the presence of indole derivatives as nucleophiles in H2O/MeCN mixture by cyclic voltammetry and controlled-potential coulometry. The reaction mechanism is believed to be oxidation of 4-(piperazin-1-yl)phenols, Michael addition reaction, oxidation of the formed adduct, another Michael addition reaction, oxidation of new adduct and hydrolysis (ECECEC). Bisindolyl-p-quinones were synthesized through the regioselective addition of indoles to electrochem. generated quinone imines in good yields at C electrode in a divided cell.

The article 《Electrochemical oxidation of 4-(piperazin-1-yl)phenols in the presence of indole derivatives: The unique regioselectivity in the synthesis of highly conjugated bisindolyl-p-quinone derivatives》 also mentions many details about this compound(67914-60-7)Application In Synthesis of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Sources of common compounds: 1194-22-5

The article 《Cocrystal structure, thermal behavior, and DFT calculations between FOX-7 and 1,10-Phenanthroline》 also mentions many details about this compound(1194-22-5)Safety of 6-Hydroxy-2-methylpyrimidin-4(3H)-one, you can pay attention to it, because details determine success or failure

Safety of 6-Hydroxy-2-methylpyrimidin-4(3H)-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Cocrystal structure, thermal behavior, and DFT calculations between FOX-7 and 1,10-Phenanthroline. Author is Li, Keyao; Ren, Xiangwen; Fu, Shuqin; Zhu, Jiaping.

Cocrystal of FOX-7 (1,1-diamino-2,2-dinitroethene) and Phen (1,10-Phenanthroline) has been synthesized and characterized by X-ray crystallog. The single crystal results show that FOX-7 and its cocrystal were crystallized in the monoclinic space groups P21/n and P21/c, resp. Thermal stability of FOX-7 and FOX-7·Phen were studied by DSC, the first exothermic peak temperatures (TP) of FOX-7 and FOX-7·Phen occurs at 223.2 and 232.7 °C, resp.; indicating that FOX-7·Phen is more stable than FOX-7. Thermokinetic parameters such as the activation energy Ea and pre-exponential factor A were 321.4 kJ mol-1 and 1.166 x 1033 s-1, resp. DFT studies including geometry optimization, HOMO-LUMO anal., Mulliken charge and UV-visible spectral data were also calculated by DFT-B3LYP/6-31 + G** level.

The article 《Cocrystal structure, thermal behavior, and DFT calculations between FOX-7 and 1,10-Phenanthroline》 also mentions many details about this compound(1194-22-5)Safety of 6-Hydroxy-2-methylpyrimidin-4(3H)-one, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Discovery of 70-23-5

The article 《Synthesis of the deacetoxytubuvaline fragment of pretubulysin and its lipophilic analogs for enhanced permeability in cancer cell lines》 also mentions many details about this compound(70-23-5)Safety of Ethyl 3-bromo-2-oxopropanoate, you can pay attention to it, because details determine success or failure

Safety of Ethyl 3-bromo-2-oxopropanoate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Synthesis of the deacetoxytubuvaline fragment of pretubulysin and its lipophilic analogs for enhanced permeability in cancer cell lines. Author is Reddy, Ramesh B.; Dudhe, Premansh; Chelvam, Venkatesh.

In the last two decades, tubulysins have emerged as alternatives to microtubule depolymerizing agents such as colchicine and vinblastine, which are well-established anticancer agents. However, the complex structure of tubulysins has always posed a challenge for synthetic chemists to scale up the production of these compounds We report a new strategy for the practical gram-scale synthesis of a (4R)-4-[( tert-butoxycarbonyl)amino]-5-methylhexanoic acid through regioselective cleavage of a chiral aziridine ring with a vinyl Grignard reagent to afford tert-Bu [(1R)-1-isopropylbut-3-en-1-yl]carbamate, which was subjected to regioselective hydroboration-oxidation with 9-BBN. The resulting (4R)-4-[( tert-butoxycarbonyl)amino]-5-methylhexanoic acid was successfully transformed into the deacetoxytubuvaline fragment of pretubulysin or its highly lipophilic methyl-substituted thiazole and oxazole analogs for incorporation into pretubulysins. Increasing the lipophilicity of tubulysin or pretubulysin mols. should enhance their cell permeability and cytotoxicity in cancer cell lines.

The article 《Synthesis of the deacetoxytubuvaline fragment of pretubulysin and its lipophilic analogs for enhanced permeability in cancer cell lines》 also mentions many details about this compound(70-23-5)Safety of Ethyl 3-bromo-2-oxopropanoate, you can pay attention to it, because details determine success or failure

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Share an extended knowledge of a compound : 67914-60-7

After consulting a lot of data, we found that this compound(67914-60-7)Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone can be used in many types of reactions. And in most cases, this compound has more advantages.

Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about New process for synthesis of 1-acetyl-4-(4-hydroxyphenyl)piperazine. Author is Zheng, Chun-zhi; Zhang, Guo-hua; Jiang, Da-feng.

The synthesis of the target compound was achieved (37.5% overall yield) by a sequence involving a chlorination, cyclization and acylation using bis(2-chloroethyl)amine hydrochloride and aminophenol as reactants. The product thus obtained [i.e., 1-[4-(4-Hydroxyphenyl)-1-piperazinyl]ethanone] was confirmed by IR, 1H-NMR.

After consulting a lot of data, we found that this compound(67914-60-7)Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

The important role of 1194-22-5

After consulting a lot of data, we found that this compound(1194-22-5)Quality Control of 6-Hydroxy-2-methylpyrimidin-4(3H)-one can be used in many types of reactions. And in most cases, this compound has more advantages.

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Infrared spectra of the biological molecule 4,6-dihydroxy-2-methylpyrimidine, the main research direction is IR spectra hydroxymethylpyrimidine; pyrimidine derivative IR spectra.Quality Control of 6-Hydroxy-2-methylpyrimidin-4(3H)-one.

The IR absorption spectra of 4,6-dihydroxy-2-methylpyrimidine were recorded spectrophotometrically in the region 250-4000 cm-1 using KBr and Nujol mull techniques. The spectra were analyzed assuming C2v point group symmetry for the mol. The assignments were proposed and discussed and the tautomeric behavior of the mol. was also discussed.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

What kind of challenge would you like to see in a future of compound: 7789-45-9

After consulting a lot of data, we found that this compound(7789-45-9)HPLC of Formula: 7789-45-9 can be used in many types of reactions. And in most cases, this compound has more advantages.

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Precise Control of Both Dispersity and Molecular Weight Distribution Shape by Polymer Blending, published in 2021-08-23, which mentions a compound: 7789-45-9, Name is Cupric bromide, Molecular Br2Cu, HPLC of Formula: 7789-45-9.

The breadth and the shape of mol. weight distributions can significantly influence fundamental polymer properties that are critical for various applications. However, current approaches require the extensive synthesis of multiple polymers, are limited in dispersity precision and are typically incapable of simultaneously controlling both the dispersity and the shape of mol. weight distributions. Here we report a simplified approach, whereby on mixing two polymers (one of high D and one of low D), any intermediate dispersity value can be obtained (e.g. from 1.08 to 1.84). Unrivalled precision is achieved, with dispersity values obtained to even the nearest 0.01 (e.g. 1.37→1.38→1.39→1.40→1.41→1.42→1.43→1.44→1.45), while maintaining fairly monomodal mol. weight distributions. This approach was also employed to control the shape of mol. weight distributions and to obtain diblock copolymers with high dispersity accuracy. The straightforward nature of our methodol. alongside its compatibility with a wide range of polymerization protocols (e.g. ATRP, RAFT), significantly expands the toolbox of tailored polymeric materials and makes them accessible to all researchers.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem