Day: March 30, 2022

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Energetic Salts with π-Stacking and Hydrogen-Bonding Interactions Lead the Way to Future Energetic Materials, published in 2015-02-04, which mentions a compound: 1194-22-5, Name is 6-Hydroxy-2-methylpyrimidin-4(3H)-one, Molecular C5H6N2O2, Application of 1194-22-5.

Among energetic materials, there are two significant challenges facing researchers: (1) to develop ionic CHNO explosives with higher densities than their parent nonionic mols. and (2) to achieve a fine balance between high detonation performance and low sensitivity. We report a surprising energetic salt, hydroxylammonium 3-dinitromethanide-1,2,4-triazolone, that exhibits exceptional properties, viz., higher d., superior detonation performance, and improved thermal, impact, and friction stabilities, then those of its precursor, 3-dinitromethyl-1,2,4-triazolone. The solid-state structure features of the new energetic salt were investigated with X-ray diffraction which showed π-stacking and hydrogen-bonding interactions that contribute to closer packing and higher d. According to the exptl. results and theor. anal., the newly designed energetic salt also gives rise to a workable compromise in high detonation properties and desirable stabilities. These findings will enhance the future prospects for rational energetic materials design and commence a new chapter in this field.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(SMILESS: CC(N1CCN(C2=CC=C(O)C=C2)CC1)=O,cas:67914-60-7) is researched.Application In Synthesis of 2-(2-Bromoethoxy)tetrahydro-2H-pyran. The article 《1-(4-Hydroxyphenyl)piperazine-1,4-diium tetrachloridocobalt(II) monohydrate》 in relation to this compound, is published in Acta Crystallographica, Section E: Structure Reports Online. Let’s take a look at the latest research on this compound (cas:67914-60-7).

The asym. unit of the title inorganic-organic hybrid compound, (C10H16N2O)[CoCl4]·H2O, consists of a tetrahedral [CoCl4]2- anion, together with a [C10H18N2O]2+ cation and a water mol. Crystal cohesion is achieved through N-H···Cl, O-H···Cl and N-H···O hydrogen bonds between organic cations, inorganic anions and the water mols., building up a three-dimensional network.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Cupric bromide, is researched, Molecular Br2Cu, CAS is 7789-45-9, about A new square pyramidal copper(II) complex [Cu(C10H24N4)Br]Br: Crystal structure, thermal analysis, Hirschfeld surfaces, electrical and semiconducting properties.COA of Formula: Br2Cu.

A new organic-inorganic Cu(II) bromide complex material [Cu(C10H24N4)Br]Br was synthesized by hydrothermal method. Blue-violet crystals were characterized by x-ray single crystal diffraction, crystallizing in the orthorhombic system, noncentrosym. space group P212121, with the following unit-cell parameters: a 8.3536(1) Å, b 12.7161(3) Å, c 14.1982(3) Å. The Cu(II) sites adopt a square pyramidal distorted geometry. The crystal structure first reveals a 1-dimensional (1D) network along the a axis based on N-H···Br interactions. The dimensionality is further increased to (3D) by C-H···Br weak interactions. Hirshfeld surfaces anal. was used to study the intermol. interactions in the crystal lattices. It was then found that X-H···Br (X = N or C) contacts play an important role within the at. architecture. Besides, the phase transitions, elec. and optical properties of [Cu(C10H24N4)Br]Br were investigated and revealed a phase transition at T = 343 K. The temperature dependence of the elec. conductivity confirmed the phase transition that was also well detected with DSC. The calculated activation energies of the conduction process for the two phases are EaI = 0.30 eV, and EaII = 0.69 eV.

If you want to learn more about this compound(Cupric bromide)COA of Formula: Br2Cu, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(7789-45-9).

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Electric Literature of C3H3NO. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Oxazole, is researched, Molecular C3H3NO, CAS is 288-42-6, about Antiproliferative activity of thiazole and oxazole derivatives: A systematic review of in vitro and in vivo studies. Author is Guerrero-Pepinosa, Nancy Y.; Cardona-Trujillo, Maria C.; Garzon-Castano, Sandra C.; Veloza, Luz Angela; Sepulveda-Arias, Juan C..

A review. Thiazole and oxazole are compounds with a heterocyclic nucleus that have attracted the attention of medicinal chem. due to the great variety of biol. activities that they enable. In recent years, their study has increased, finding a wide range of biol. activities, including antifungal, antiparasitic, anti-inflammatory, and anticancer activities. This systematic review provides evidence from the literature on the antiproliferative and antitumor activities of thiazole and oxazole and their derivatives from 2014 to Apr. 2020. Three bibliog. databases were consulted (PubMed, Web of Science, and Scopus), and a total of 32 studies were included in this paper based on our eligibility criteria. The anal. of the activity-structure relationship allows us to conclude that most of the promising compounds identified contained thiazole nuclei or derivatives

If you want to learn more about this compound(Oxazole)Electric Literature of C3H3NO, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(288-42-6).

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Recommanded Product: 6-Hydroxy-2-methylpyrimidin-4(3H)-one. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Investigation of FOX-7 Polymorphs: new polymorphs – ε and ζ. Author is Kushtaev, Alexander A.; Yudin, Nikolay V.; Kondakova, Natalia N.; Ilicheva, Natalia N.; Vu, Tuan Q.; Zbarskiy, Vitold L..

Polymorphism of 1,1-diamino-2,2-dinitroethene (FOX-7, DADNE) has investigated by X-ray powder diffraction (XRD), differential scanning calorimetry (DSC), thermo gravimetric anal. (TGA), IR-spectroscopy. Two previously unknown polymorph modifications of FOX-7 – ε and ζ were discovered. ε-FOX-7 has prepared by hydrolysis of 2-(dinitromethylene)-5,5-dinitropyrimidine-4,6(1H,3H,5H)-dione in a media with pH up 7-8 to Ho≈-3 and 2-(dinitromethylene)imidazolidine-4,5-dione in aqueous ammonia. Ε-FOX-7 is a stable and exists in temperature range 273-378 K. ζ-polymorph of FOX-7 can be obtained at ε-FOX-7 heating to 378-380 K. ζ→ε polymorph transition is a reversible and occurs at 361.7±3.1 K. At 433-453 K ζ-FOX-7 transforms to γ-polymorph. ζ→γ phase transition temperature range was determined using IR-spectroscopy because it is invisible on DSC curves. IR-spectra of ε and ζ polymorphs are significantly distinct from α-, β- and γ-FOX-7. ε-FOX-7, in contrast to monoclinic α-polymorph, has orthorhombic type of crystal system (space group P212121). Based on received data, new scheme of FOX-7 polymorph transition is proposed.

If you want to learn more about this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Recommanded Product: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1194-22-5).

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Bioorganic Chemistry called Design, synthesis and biological evaluation of a novel tubulin inhibitor SKLB0565 targeting the colchicine binding site, Author is Hu, Xi; Li, Lu; Zhang, Qiangsheng; Wang, Qianqian; Feng, Zhanzhan; Xu, Ying; Xia, Yong; Yu, Luoting, which mentions a compound: 5451-40-1, SMILESS is C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2, Molecular C5H2Cl2N4, SDS of cas: 5451-40-1.

A series of 3-(((9H-purin-6-yl)amino)methyl)pyridin-2(1H)-one derivatives were designed, synthesized and confirmed as tubulin polymerization inhibitors. All compounds were evaluated for their anti-proliferative activities on three colorectal carcinoma (CRC) cell lines. Among these compounds, SKLB0565 displayed noteworthy potency against eight CRC cell lines with IC50 values ranging from 0.012μM and 0.081μM. Besides, SKLB0565 inhibited tubulin polymerization, caused G2/M phase cell cycle arrest, depolarized mitochondria and induced cell apoptosis in CRC cells. Furthermore, SKLB0565 suppressed cell migration and disrupted the capillary tube formation of human umbilical vein endothelial cells (HUVECs). In this SKLB0565 is a promising anti-tubulin agent for CRC therapy which is worthy of further evaluation is clarified.

If you want to learn more about this compound(2,6-Dichloropurine)SDS of cas: 5451-40-1, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(5451-40-1).

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Application In Synthesis of Ethyl 3-bromo-2-oxopropanoate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Design, synthesis, in vitro evaluation and molecular docking study of N’-arylidene imidazo[1,2-a]pyridine -2-carbohydrazide derivatives as novel tyrosinase inhibitors.

A novel series of imidazo[1,2-a]pyridine 2-carbohydrazide derivatives bearing different arylidene pendants I [R = 4-OH, 2-MeO, 3-OH-4-MeO, etc.] were designed, synthesized and evaluated for their inhibitory activity against mushroom tyrosinase. It was found that compounds I [R = 3-NO2, 4-OH] exhibited the best tyrosinase inhibitory activity with IC50 values of 7.19 and 8.11μM, resp. These results were comparable to that of kojic acid as the reference drug (IC50 = 9.64±0.5μM). Addnl., mol. docking anal. was performed to study the interactions and binding modes of compounds I [R = 3-NO2, 4-OH, 2,4-di-OH] which showed the potential of two critical pi-pi interactions with His263 and Phe264 in the active site of tyrosinase. The results indicated that compounds I [R = 3-NO2, 4-OH] could be introduced as potent tyrosinase inhibitors that might serve as promising candidates in medicine, cosmetics or food industry.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Formula: C5H2Cl2N4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A3 Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary. Author is Lee, Yoonji; Hou, Xiyan; Lee, Jin Hee; Nayak, Akshata; Alexander, Varughese; Sharma, Pankaz K.; Chang, Hyerim; Phan, Khai; Gao, Zhan-Guo; Jacobson, Kenneth A.; Choi, Sun; Jeong, Lak Shin.

Distinguishing compounds′ agonistic or antagonistic behavior would be of great utility for the rational discovery of selective modulators. We synthesized truncated nucleoside derivatives and discovered 6c (I)(Ki = 2.40 nM) as a potent human A3 adenosine receptor (hA3AR) agonist, and subtle chem. modification induced a shift from antagonist to agonist. We elucidated this shift by developing new hA3AR homol. models that consider the pharmacol. profiles of the ligands. Taken together with mol. dynamics (MD) simulation and three-dimensional (3D) structural network anal. of the receptor-ligand complex, the results indicated that the hydrogen bonding with Thr943.36 and His2727.43 could make a stable interaction between the 3′-amino group with TM3 and TM7, and the corresponding induced-fit effects may play important roles in rendering the agonistic effect. Our results provide a more precise understanding of the compounds′ actions at the at. level and a rationale for the design of new drugs with specific pharmacol. profiles.

If you want to learn more about this compound(2,6-Dichloropurine)Formula: C5H2Cl2N4, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(5451-40-1).

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Cupric bromide, is researched, Molecular Br2Cu, CAS is 7789-45-9, about Bioinspired oil-soluble polymers based on catecholamine chemistry for reduced friction, the main research direction is bioinspired oil polymer catecholamine chem reduced friction.Safety of Cupric bromide.

Reduction of friction and wear contributes significantly to energy saving for mech. system as considerable energy has been consumed in various forms of friction worldwide. In the present study, two kinds of dopamine-based oil-soluble polymers were synthesized by atom transfer radical polymerization (DOPA-BiBB-pLMA) and photopolymerization (DOPA-I2959-pLMA), and modified onto the Ti6Al4V sheet by the “”grafting to”” method. The characterizations of NMR, Fourier transform IR spectrum, water contact angle, and XPS confirmed that the polymers were successfully grafted onto the Ti6Al4V surface. Addnl., a series of tribol. tests were performed in oil environment using a universal materials tester under different exptl. conditions. It was shown that the coefficient of friction using the Ti6Al4V sheets grafted by the dopamine-based polymers was reduced by 23.5-46.2% compared with bare Ti6Al4V sheet. Furthermore, the wear depth and wear volume were also greatly decreased with the introduction of the dopamine-based polymers. DOPA-I2959-pLMA showed slightly better lubrication enhancement than that of DOPA-BiBB-pLMA, which may be attributed to the relatively higher polymerization degree. In summary, a universal “”grafting to”” surface modification approach was proposed bioinspired by catecholamine chem., which remarkably reduced friction and wear of the tribopairs with the introduction of oil-soluble polymers.

If you want to learn more about this compound(Cupric bromide)Safety of Cupric bromide, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(7789-45-9).

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Related Products of 7789-45-9. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Cupric bromide, is researched, Molecular Br2Cu, CAS is 7789-45-9, about Light-Activated Adhesion and Debonding of Underwater Pressure-Sensitive Adhesives. Author is Tseng, Yen-Ming; Narayanan, Amal; Mishra, Kaushik; Liu, Xinhao; Joy, Abraham.

Pressure-sensitive adhesives (PSAs) such as sticky notes and labels are a ubiquitous part of modern society. PSAs with a wide range of peel adhesion strength are designed by tailoring the bulk and surface properties of the adhesive. However, designing an adhesive with strong initial adhesion but showing an on-demand decrease in adhesion has been an enduring challenge in the design of PSAs. To address this challenge, we designed alkoxyphenacyl-based polyurethane (APPU) PSAs that show a photoactivated increase and decrease in peel strength. With increasing time of light exposure, the failure mode of our PSAs shifted from cohesive to adhesive failure, providing residue-free removal with up to 83% decrease in peel strength. The APPU-PSAs also adhere to substrates submerged underwater and show a similar photoinduced decrease in adhesion strength.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem