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The three-component aminoallylation reaction of the activated olefins 2 with the phthalimide 1a and allyl chloride proceeded very smoothly in the presence of Pd2dba3·CHCl3 (5 mol %)/P(4-FC6H4)3 (40 mol %) and Cs2CO3 (3 equiv against 2) in dichloromethane at room temperature to give the corresponding aminoallylated products, N-pent-4-enylphthalimides 3, in 58-99% yields. The reaction of oxazolidinone 1b also proceeded very smoothly to give N-(2,2-dicyano-1-phenylpent-4-enyl)-oxazolidinone in a quantitative yield; however, the Tsuji-Trost-type allylation products 4 were obtained in the case of dibenzylamine, N-tosylaniline, and pyrrolidin-2-one. Further, 2 underwent cycloaddition with N-tosylvinylaziridine 9a in the presence of Pd2dba3·CHCl3 (5 mol %)/P(4-FC6H4)3 (40 mol %) in THF at room temperature, giving the corresponding pyrrolidines 11 in 69-99% yields.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H310NO – PubChem

 

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Formula: C3H5NO2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 497-25-6, name is Oxazolidin-2-one. In an article,Which mentioned a new discovery about 497-25-6

The invention is a process for the preparation of 2-oxazolidinones which comprises contacting a 2-hydroxyalkyl carbamate with an alkylene oxide or alkylene carbonate in the presence of a catalytic amount of a quaternary ammonium halide, quaternary phosphonium halide, a group I metal carbonate, hydroxide, oxide or halide, or a group II metal carbonate, hydroxide, oxide or halide under conditions such that a 2-oxazolidinone is prepared.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H70NO – PubChem

 

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The present invention relates to combination therapies comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and/or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either possess a broad range of anti-bacterial activity and advantageous toxicological properties or are prodrugs of compounds having said activity.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H158NO – PubChem

 

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Carbon dioxide (CO2), a well-known greenhouse gas, is also a nontoxic, readily accessible, and renewable one-carbon (C1) source. However, owing to its thermodynamic stability and kinetic inertness, the efficient utilization of CO2 is challenging. Much effort has been devoted to achieving efficient and selective organic transformations of CO2. Recently, the synthesis of important oxazolidin-2-ones from unsaturated amines by using CO2 has attracted much attention and been heavily studied. This Focus Review presents recent advances in this area by using homogenous catalysis. The cyclization of amines that contain alkynes, alkenes, and allenes with CO2 is discussed, and possible reaction mechanisms and applications of these transformations are also described.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1204NO – PubChem

 

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Synthetic Route of 497-25-6, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 497-25-6, molcular formula is C3H5NO2, introducing its new discovery.

Mercury(II) acetate reacts with 2-oxazolidone (1,3-oxazolidin-2-one, C3H5NO2) in methanol to produce (L = C3H4NO2, the anion of 2-oxazolidone).An X-ray diffraction study has shown that the Hg atom binds to the ring nitrogen atom with a near linear N-Hg-N geometry.There are two HgL2 groups in the asymmetric unit which are orthogonal to one another and linked via pairs of Hg…O interactions to form dimers.These bind to neighbouring units via weaker Hg-O interactions to form a one-dimensional chain polymer.When yttrium or lanthanide(III) nitrates are added to the reaction an isostructural series of compounds of formula <(Hg2L4M(NO3)3)n>, where M = La-Yb or Y, is obtained.A representative member of this group, <(Hg2L4Gd(NO3)3)n>, was studied by single-crystal X-ray diffraction methods.This forms a two-dimensional polymeric array comprising two sizes of metallamacrocyclic rings (16- and 48-membered) fused together, with the gadolinium(III) ion surrounded by nine oxygen atoms in a trigonal tricapped-prismatic arrangement.The IR, UV/VIS reflectance, EPR and solid-state NMR spectroscopic properties of these complexes and, where appropriate, those of and are reported.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H401NO – PubChem

 

Archives for Chemistry Experiments of 1676-86-4

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A series of novel disulfide-containing triblock copolymers, poly(ethylene glycol)-b-poly(l-lysine)-b-poly(rac-leucine) (PEG-SS-PLys-PLeu), were prepared. In an aqueous solution, the copolymers could self-assemble to form core-shell-corona micelles with a disulfide-linked detachable PEG corona, since the PLys middle shell with primary amine groups was linked by a disulfide-containing cross-linker. The morphology and stability of self-assembled micelles were characterized by TEM, DLS and SEM. In the intracellular environment, the micelles underwent destruction of the cross-linked shell with detachment of the PEG corona due to the cleavage of disulfide bonds, followed by the collapse of micelles. The in vitro drug release in response to GSH was further studied. Interestingly, it was found that the micelles not only exhibited reduced drug loss in extracellular environments, but also drastically accelerated drug release at the cytoplasmic GSH level, leading to enhanced growth inhibition of HeLa cells. The glutathione-responsive micelles might have great potential in intracellular drug delivery.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2740NO – PubChem

 

More research is needed about Oxazolidin-2-one

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A novel chalcogen-mediated oxyfunctionalization mode of ynamides for the synthesis of alpha-chalcogenyl acrylamides has been developed. Independent of metal catalysts, external oxidants and additives, this mild process afforded a range of structurally diverse alpha-chalcogenyl acrylamides, including alpha-selanyl acrylamides and alpha-tellanyl acrylamides. Interestingly, diverse ynamides tolerated in this approach gave different stereoselectivities.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H624NO – PubChem

 

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The reaction of five- and six-membered cyclic thiourethanes with acetyl nitrate results in a vigorous reaction that generates copious amounts of red-brown nitrogen oxide fumes and produces the corresponding cyclic N-nitrourethanes in high yields (>95%). The overall yield of the cyclic N-nitrourethanes starting from an aminoalcohol using the ” thiourethane” route is superior to the conventional route going through the cyclic urethane. Copyright

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1133NO – PubChem

 

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The efficient utilization of carbon dioxide (CO2) as a C1-building block in organic synthesis has attracted considerable attention in view of sustainable chemistry and green chemistry concepts. Recently, three-component reaction of amines, epoxides, and carbon dioxide has emerged as a powerful strategy for the synthesis of biologically important organic carbamates. In this review, we try to provide a comprehensive and updated overview of recent developments in this interesting research arena with special emphasis on the mechanistic aspects of the reactions. The review is divided into two major sections. The first section focuses exclusively on synthesis of acyclic carbonates, while the second covers construction of cyclic carbamates.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H619NO – PubChem

 

Brief introduction of (R)-4-Benzyl-2-oxazolidinone

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Aryl GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1636NO – PubChem