One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, COA of Formula: C12H13NO3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 160695-26-1, Name is (R)-4-Phenyl-3-propionyloxazolidin-2-one, molecular formula is C12H13NO3
An enantioselective convergent route to pamamycin 621A
(Figure presented) An effective approach to the total synthesis of natural antibiotic pamamycin 621A is described, in which the stereogenic centers at the C-13 and C-15 were taken from a chiral building block derived from the inexpensive d-glucolactone while all others (except the C-10) were installed via chiral auxiliary-induced asymmetric Evans/Crimmins aldol reactions. In the synthesis of the smaller/lower fragment, an antiselective Evans aldol condensation was found to occur only if a stoichiometric (rather than catalytic as reported in the literature) amount of magnesium chloride was present. A previously unknown effect of the steric bulkiness of the pyridine base employed on the stereochemical outcome of the formation of the THF ring in the presence of a chiral auxiliary was also observed. The THF rings in the larger/upper fragment were similarly synthesized with a high level of stereoselectivity from a linear precursor carrying a chiral auxiliary via intramolecular O-alkylations, most notably even under acidic conditions. The basic dimethylamino functionality at the C-15 was installed at the final stage of the whole synthesis, with those otherwise unavoidable side reactions in the conversion of the azido group effectively circumvented through using a very mild yet largely forgotten tributyltin reduction protocol.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C12H13NO3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 160695-26-1, in my other articles.
Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H2247NO – PubChem