Extracurricular laboratory:new discovery of Oxazolidin-2-one

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COMPOUNDS AND THEIR METHODS OF USE

The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H209NO – PubChem

 

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Tandem chain extension-Mannich reaction: An approach to beta-proline derivatives

A zinc carbenoid-initiated chain extension reaction provides access to an organometallic intermediate, which can be used to capture activated imines. Deprotection of the nitrogen and reduction provides access to racemic derivatives of beta-proline. The relative stereochemistry of the beta-proline can be controlled through use of different activating groups on the imine nitrogen.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H652NO – PubChem

 

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Regioselective Hydroamination Using a Directed Nucleopalladation/Protodepalladation Strategy

Alkene hydroamination is an attractive approach for converting alkenes into structurally complex amine products. Several different strategies have been pursued over the past few decades to achieve this historically challenging reaction. One of the key issues associated with this transformation is control of regioselectivity, which is particularly difficult for internal non-conjugated alkenes. Our group has recently found success using a removable bidentate auxiliary to control regioselectivity and stabilize the key nucleopalladated intermediate in a palladium(II)-catalyzed alkene hydroamination with N-H nucleophiles. This article describes the historical context for this work, the underlying conceptual logic, our results to date, and the future outlook.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H579NO – PubChem

 

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Photo-oxidation of Oxazolidones and Hydantoins in the Presence of Benzophenone

Irradiation in the presence of benzophenone and oxygen of nitrogen-containing heterocycles having an NCO group yields products arising out of regioselective oxidation alpha to the nitrogen atom.Direct irradiation (in the absence of benzophenone and oxygen) of 5-methyl- and 5,5-dimethyl-hydantoins yields allophanates.The first step of this reaction involves the homolysis of the C(4) – C(5) bond of the hydantoin.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H568NO – PubChem

 

Can You Really Do Chemisty Experiments About 695-53-4

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Polymeric and polymer-ligated spirobicyclic zwitterionic Janovsky complexes

A novel approach to the synthesis of spirobicyclic Janovsky complexes is described. The complexes were prepared on silica and polystyrene polymeric supports as well as on a solution-borne poly(carbodiimide) polymer with 100% atom economy. A carbon-centered intramolecular de-aromatizing nucleophilic aromatic substitution ipso-cyclization mechanism describes the synthesis of these spirobicyclics. The molecules were characterized by solution and solid-state 1H and 13C NMR, IR, and MS. Crown Copyright

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1350NO – PubChem

 

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Preparation of 2-aminoalkanesulfonic acid

The invention is a process for the preparation of the metal salt of 2-aminoalkanesulfonic acid which comprises contacting a 2-oxazolidinone with a water-soluble metal sulfite or a water-soluble metal hydrogen sulfite in aqueous solution under conditions such that a metal salt of 2-aminoethanesulfonic acid is prepared.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H124NO – PubChem

 

Properties and Exciting Facts About 5,5-Dimethyloxazolidine-2,4-dione

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Development of novel neural Embryonic Stem Cell Tests for high-throughput screening of embryotoxic chemicals

There is a great demand for appropriate alternative methods to rapidly evaluate the developmental and reproductive toxicity of a wide variety of chemicals. We used the differentiation of mouse embryonic stem cells (mESCs) into cardiomyocytes as a basis for establishing a rapid and highly reproducible in vitro embryotoxicity test known as the Hand1- Luc Embryonic Stem Cell Test (Hand1-Luc EST). In this study, we developed novel neural-Luc ESTs using two marker genes for neural development, tubulin beta-3 (Tubb3) and Reelin (Reln), and evaluated the capacity of these tests to predict developmental toxicity. In addition, we tested whether an integrated approach (a combination of neural-Luc ESTs and the Hand1-Luc EST) improved developmental toxicant detection. To perform our neural-Luc ESTs, we needed to generate stable transgenic mESCs with individual promoters linked to the luciferase gene, and to establish that similar changes in promoter activities and mRNA expression levels occur during neural differentiation. Based on the concentration-response curves of 15 developmental toxicants and 17 non-developmental toxic chemicals, we derived a prediction formula and assessed the capacity of this formula to predict developmental toxicity. Although both were highly sensitive and specific for predicting developmental toxicity, neural-Luc ESTs had similar predictive capacities. In contrast, neural-Luc ESTs and Hand1-Luc EST had significantly different predictive powers. As expected, the combination of these ESTs increased the sensitivity of developmental toxicant detection. These results demonstrate the convenience and the usefulness of this combination of ESTs as an alternative assay system for future toxicological and mechanistic studies of developmental toxicity.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1368NO – PubChem

 

Some scientific research about 102029-44-7

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Studies directed toward the total synthesis of pinnatoxin A: Synthesis of the 6,5,6-dispiroketal (BCD ring) system by double hemiketal formation/hetero-Michael addition strategy

An efficient, highly stereoselective synthesis of the C10-C26 portion of pinnatoxin A has been achieved, wherein the key step is a highly stereoselective construction of the 6,5,6-dispiroketal (BCD ring) system by an intramolecular hetero-Michael addition of a hemiketal alkoxide reversibly formed under the influence of lithium methoxide.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1941NO – PubChem

 

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Iridium catalysts for the asymmetric hydrogenation of olefins with nontraditional functional substituents

Chiral iridium catalysts have now been used in the asymmetric hydrogenation of largely unfunctionalized olefins for a decade. Recently, they have also been applied to substrates with more exotic functional groups, including non-coordinating ones. These, unlike coordinating substituents, cannot direct asymmetric hydrogenation by rhodium- or ruthenium-based catalysts. This review discusses several classes of these less familiar substrates, outlines the progress that has been made toward their stereoselective hydrogenation, and highlights the role of iridium complexes in this emerging field. We hope this will inspire researchers to consider iridium-catalyzed asymmetric hydrogenation as a potential route to a broad range of chiral compounds.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H443NO – PubChem

 

Extended knowledge of (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one

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Process for the stereoselective synthesis of 3-substituted 2-thiomethylpropionic acids

Process for the stereoselective synthesis of 3-substituted 2-thiomethylpropionic acids Compounds of the formula I STR1 in which R1 and R2 are as defined can be prepared stereoselectively by reaction of acrylic acid or derivatives thereof or propionic acid or derivatives thereof with a chiral auxiliary, reaction with a mercaptan, stereoselective alkylation and subsequent hydrolysis and oxidation.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H2114NO – PubChem