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Approaches to Obtaining Fluorinated alpha-Amino Acids

Fluorine does not belong to the pool of chemical elements that nature uses to build organic matter. However, chemists have exploited the unique properties of fluorine and produced countless fluoro-organic compounds without which our everyday lives would be unimaginable. The incorporation of fluorine into amino acids established a completely new class of amino acids and their properties, and those of the biopolymers constructed from them are extremely interesting. Increasing interest in this class of amino acids caused the demand for robust and stereoselective synthetic protocols that enable straightforward access to these building blocks. Herein, we present a comprehensive account of the literature in this field going back to 1995. We place special emphasis on a particular fluorination strategy. The four main sections describe fluorinated versions of alkyl, cyclic, aromatic amino acids, and also nickel-complexes to access them. We progress by one carbon unit increments. Special cases of amino acids for which there is no natural counterpart are described at the end of each section. Synthetic access to each of the amino acids is summarized in form of a table at the end of this article with the aim to make the information easily accessible to the reader.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H838NO – PubChem

 

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Ciprofloxacin-induced acute psychosis in a patient with multidrug-resistant tuberculosis

Tuberculosis (TB) increasingly appears in a multidrug-resistant form (MDR-TB) in Europe, too. Treatment remains difficult due to various side effects of the multi-drug-regimens. Ciprofloxacin is widely used as one of the few TB-second-line drugs. We report on the course of a ciprofloxacin-induced acute psychosis in a patient with MDR(isoniazid, streptomycin)-TB which resolved after cessation of ciprofloxacin treatment and introduction of a novel oxazolidone. Careful treatment considerations particularly in patients with additional predisposing factors to neuropsychiatric symptoms are recommended in the potentially dangerous MDR-TB, thus creating an enormous therapeutic challenge.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H864NO – PubChem

 

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MICROBIOCIDAL OXADIAZOLE DERIVATIVES

Compounds of the formula (I), wherein the substituents are as defined in claim 1, useful as a pesticides, especially as fungicides.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1222NO – PubChem

 

More research is needed about (R)-4-Benzyl-2-oxazolidinone

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Rapid synthesis of 3-amino isocoumarin derivatives from ynamides

A novel and efficient fast synthesis of 3-amino isocoumarins in good to excellent yields is reported. These interesting scaffolds can be obtained either in a single step from readily available ynamides or in a two-step sequence from the corresponding alkynyl bromide after C-N cross-coupling. This protocol, which only requires a Br¡ãnsted or Lewis acid as a promoter, offers an alternative approach toward synthesizing 3-substituted isocoumarins under smooth and fast conditions.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1841NO – PubChem

 

Extended knowledge of (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one

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THIENOPYRIMIDINES AS MKNK1 AND MKNK2 INHIBITORS

The present invention relates to substituted thienopyrimidine compounds of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2122NO – PubChem

 

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BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS

This invention relates to novel benzofuran and benzothiophene derivatives of the general formula and their use for the treatment of hyper-proliferative disorders.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H262NO – PubChem

 

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SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS

The present invention relates generally to substituted isoquinolines and their use as tubulin polymerization inhibitors. In particular, the invention relates to substituted isoquinolines which possess useful therapeutic activity, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2364NO – PubChem

 

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Novel synthetic approaches for the synthesis of Alanine-Proline chimeras

In this review, we reported on the Proline-chimeras characterized by resembling the skeleton of Alanine (Alanine-Proline chimeras). The synthetic approaches were classified according to the position of the methyl group on the pyrrolidine ring. Moreover, the synthesis of pyroglutamic acid derivatives will be discussed due to its importance as building block and chiral pool in the asymmetric synthesis of numerous bioactive compounds. The present review will be focused on the chemical syntheses of mono-methyl substituted proline derivatives, including the contribution to the literature from 2004 to 2016.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H941NO – PubChem

 

Top Picks: new discover of (S)-3-((S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one

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Application of 189028-95-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.189028-95-3, Name is (S)-3-((S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one, molecular formula is C20H20FNO4. In a Patent£¬once mentioned of 189028-95-3

PROCESS FOR PREPARING EZETIMIBE INTERMEDIATE

The present invention refers to […] which can inhibit the cholesterol absorption and are (ezetimibe) used in the manufacture of an intermediate manufacturing method relates to compounds of formula 4, a chelatable metal compounds, and metal of formula 2 in one direction so that at step low id id compound of formula 3 to the asymmetrically reducing according to including of the present invention manufacturing method, a method that of the prior art compared to compounds of formula 4 economically, purity can be produced: < ??? 2> < ??? 3> < ??? 4> Said in formula, The X and Ph as defined during specification. (by machine translation)

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H2829NO – PubChem

 

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Chapter 2 The heterocyclic chemistry associated with the herbicide glyphosate

The search for alternative new aminoalkyl phosphonates or phosphinates with similar or dramatically improved biological activity versus glyphosate has stimulated an enormous research effort in exploratory phosphorus and heterocyclic chemistry. Many new synthetic methods have been developed over the last two decades to prepare a variety of structural analogs of glyphosate containing a modified skeleton. Despite the large numbers of compounds evaluated, none has surpassed the overall biological properties of glyphosate itself, either on the enzymatic level or under field conditions. Consequently, the search for a second-generation, glyphosate-like herbicide continues (2).

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H1002NO – PubChem