Day: November 6, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95530-58-8,(R)-4-Isopropyloxazolidin-2-one,as a common compound, the synthetic route is as follows.

95530-58-8, To a cooled (-10 0C) solution of 8-(4-fluoro-3-methylphenyl)octanoic acid (0.486 g, 1.926 mmol) in 15 mL of THF, were added stepwise triethylamine (0.69 mL, 4.952 mmol) and pivaloyl chloride (0.23 mL, 1.889 mmol). The reaction mixture was stirred at -10 0C for 1 h and then LiCl (0.080 g, 1.889 mmol) and (R)-4-iso- propyloxazolidin-2-one (0.237 g, 1.834 mmol) were added stepwise. After being warmed slowly to room temperature and stirred for overnight, the reaction mixture was diluted with ethyl acetate (80 mL) and washed with saturated NaHCO3 solution and brine. The organic layer was dried (Na2SO4), filtered, and concentrated under reduced pressure. The product was isolated by Flash column chromatography(silica gel column) eluting with 0-100 % dichloromethane/hexanes to give the title compound as colorless oil (0.547 g, 82% yield). GC-MS: tR = 6.9 min; m/z 363 (M+).

95530-58-8 (R)-4-Isopropyloxazolidin-2-one 641505, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; PANTHERA BIOPHARNA, LLC; WO2008/94592; (2008); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99395-88-7,(S)-4-Phenyloxazolidin-2-one,as a common compound, the synthetic route is as follows.

4S)-3-{[(4-Methoxybenzyl)thio]acetyl}-4-phenyI-l,3-oxazolidin-2-one; [(4-Methoxybenzyl)thio] acetic acid (1.3 g, 6.1 mmol) was dissolved in dry CH2Cl2 (40 ml) and given O0C. N,N’-Dicyclohexylcarbodiimide (DCC, 6.1 g, 6.1 mmol) and 4- (dimethylamino)pyridine (DMAP, 1.6 g, 12.9 mmol) were added and the mixture was stirred for 30 minutes. (S)-(+)-4-Phenyl-2-oxazolidinone (1,0 g, 6.1 mol) was added and the mixture was stirred at room temperature for 24 hours. The mixture was filtrated, concentrated under reduced pressure and purified by flash-chromatography (Hex : EtOAc 8:2 then 1:1). This afforded the title compound.1H-NMR (CDCl3, 200 MHz): delta 3.46-3.59 (m, 3H), 3.74-3.76 (m, 4Hj, 4.23-4.28 (m, IH), 4.68 (t, J = 8.8 Hz, IH), 5.38-5-42 (m, IH), 6.78 (d, J = 8.6 Hz, 2H), 7.14 (d, / = 8.6 Hz, 2H), 7.32-7.40 (m, 5H)., 99395-88-7

99395-88-7 (S)-4-Phenyloxazolidin-2-one 730424, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; WO2006/137793; (2006); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

99395-88-7, (S)-4-Phenyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In three 500ml flask, was added ( s) -4- phenyl-2-oxazolone 20g (0.122mol, 1eq.) And dichloromethane 200ml, cooled to between 0 ~ 10 , was added chlorotrimethylsilane 15.86g (0.146mol, 1.2eq.), kept under stirring at 0 ~ 10 30 minutes, a solution of diisopropylethylamine 39.30g (0.305mol, 2.50eq.), was added dropwise in the temperature control of the material during 0 ~ between 10 , after completion of the dropwiseaddition, stirring was continued for 2 hours at 0 ~ 10 until (s) -4- phenyl-2-oxazolone starting material by TLC the reaction was complete (monitored by TLC conditions: petroleum ether / ethyl acetate acetate = 2/1).acryloyl chloride WAS the then added 15.46 g (0.171 mol, 1.4 eq.), at The temperature at The Control of Material’s at The Addition During the BETWEEN 0 ~ 10 deg.] C, the After Addition at The Complete WAS, WAS added of 1.6 g of anhydrous Tetrabutylammonium fluoride (of TBAF, 6.1 mmol, 0.05 eq.), at The Reaction WAS AT Stirred Room temperature for 2 hours.the After Completion of at The Reaction, Reaction Solution at The WAS Poured INTO ICE 200ml of Water, and Stirred AT Room temperature for 30 minutes, at The Organic Phase WAS Separated, at The Organic Phase WAS Washed the with 10% (wt) WAS Washed the with Sodium bicarbonate Solution, at The Organic Phase WAS Separated, Evaporated to Dryness to give at The crude Product the After at The Organic Phase.Isopropyl alcohol WAS added to at The crude Product 100ml, Stirred AT 25 Suction Filtration hours to 2 deg.] C to give A White Solid Powder, and dried to give Compound at The Product 24.6 g, a yield 93%.1, 99395-88-7

The synthetic route of 99395-88-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Jiangsu Hengsheng Pharmaceutical Co., Ltd; Wang, Xilin; Ding, Zunliang; Wu, Huafeng; Wang, Zhe; Chen, Zhikuan; (9 pag.)CN105541742; (2016); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

99395-88-7, (S)-4-Phenyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 69.0 g (615 mmol) of 5-hexynoic acid and 214 mL (1540 mmol) of triethylamine in 1.0 L of anhydrous tetrahydrofuran at -25 C. under an atmosphere of nitrogen was added 83.0 mL (677 mmol) of trimethylacetyl chloride over 20 min. Upon addition a white precipitate formed and the resulting suspension was stirred for 2 h. Next, 28.7 g (677 mmol) of anhydrous lithium chloride and 100.0 g (615.0 mmol) of (4S)-4-phenyl-1,3-oxazolidin-2-one were added sequentially and the mixture was allowed to gradually warm to ambient temperature over 12 h. All volatiles were removed in vacuo and the residue was diluted with water (1 L) and extracted with ethyl acetate (3¡Á300 mL). The combined organic layers were washed with brine (250 mL), dried over magnesium sulfate, filtered and concentrated in vacuo. The crude residue was purified by silica gel chromatography eluting with a 5-50% ethyl acetate in hexanes gradient to afford the title compound as a colorless solid (135 g, 85.4%). 1H NMR (500 MHz, CDCl3): delta 7.40-7.37 (m, 2H), 7.36-7.32 (m, 1H), 7.31-7.28 (m, 2H), 5.42 (dd, J=8.9, 3.7 Hz, 1H), 4.69 (t, J=8.9 Hz, 1H), 4.28 (dd, J=9.2, 3.7 Hz, 1H), 3.13-3.02 (m, 2H), 2.24-2.21 (m, 2H), 1.94 (t, J=2.6 Hz, 1H), 1.84 (quintet, J=7.1 Hz, 2H). LC-MS: m/z (ES) 258.2 (MH)+., 99395-88-7

99395-88-7 (S)-4-Phenyloxazolidin-2-one 730424, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; Berger, Richard; Chang, Lehua; Edmondson, Scott D.; Goble, Stephen D.; Ha, Sookhee Nicole; Kar, Nam Fung; Kopka, Ihor E.; Li, Bing; Morriello, Gregori J.; Moyes, Chris R.; Shen, Dong-Ming; Wang, Liping; Zhu, Cheng; US2009/253705; (2009); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.145589-03-3,(R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.

EXAMPLE 6; Preparation of (S)-ie f-butyl-3-((S)-4-benzyloxazolidin-2-on-3-yl)-carbonyl-4- methyl-pentanoate, compound (XVI) in which Z = terf-butyl.; A solution of hexyllithium 2.3 M in hexane (18.3 ml, 42.1 mmol) is added at 0 C and under nitrogen to a solution of diisopropylamine (5.19 ml, 42.1 mmol) in anhydrous tetrahydrofuran (10 ml). After 15 minutes the solution is cooled to -78 C and a solution of (S)-4-benzyl-3-(3-methylbutanoyl)oxazolidin-2-one (compound (XV), 10 g, 38.3 mmol), in THF (5 ml) is added dropwise. After 45 minutes at -78 C, terf-butylbromoacetate (10.7 ml, 72.7 mmol) is added. The temperature is raised to 20 C in 4 hours, then a saturated solution of ammonium chloride (50 ml) is added, the tetrahydrofuran is evaporated and the suspension thus obtained is extracted twice with ethyl acetate (2 x 100 ml). The combined organic phases are washed with 0.5N HCI, brine and are dried over sodium sulphate. After evaporating the solvent in a rotary evaporator, 16.48 g of raw product are obtained (orange-coloured solid), which is purified by flash chromatography (8:2 cyclohexane/ethyl acetate), obtaining 6.1 g of product as white solid (yield 50%). Alternatively the product can be purified by crystallizing the raw reaction product from isopropanol.1 H NMR (300 MHz, CDCI3, 298K) delta 7.37-7.20 (m, 5H), 4.70-4.60 (m, 1 H), 4.20- 4.08 (m, 3H), 3.35-3.25 (dd, J = 13.5 Hz, 3.1 Hz.1 H), 2.85-2.75 (dd, J = 28.9, 10.1 Hz, 1 H), 2.75-2.65 (dd, J = 13.8, 10.1 1 Hz, 1 H), 2.47-2.37 (dd, J = 16.8 Hz, 3.1 Hz, 1 H), 2.01 -1 .91 (m, 1 H), 1 .45-1 .35 (s, 9H).1 .05-0.95 (d, J = 6.7 Hz, 3H), 0.95-0.85 (d, J = 6.7 Hz, 3H).13C NMR (75 MHz, CDCI3, 298K) delta 176.8, 173.1 , 154.4, 137.1 , 130.5, 130.2, 178.3, 81 .6, 66.9, 57.0, 45.4, 38.5, 34.6, 31 .1 , 29.2, 21 .7, 19.5., 145589-03-3

As the paragraph descriping shows that 145589-03-3 is playing an increasingly important role.

Reference£º
Patent; CHEMO IBERICA, S.A.; TADDEI, Maurizio; RUSSO, Adele; CINI, Elena; RIVA, Renata; RASPARINI, Marcello; CARCONE, Luca; BANFI, Luca; VITALE, Romina; ROSEBLADE, Stephen; ZANOTTI-GEROSA, Antonio Carlo; WO2011/151442; (2011); A2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99395-88-7,(S)-4-Phenyloxazolidin-2-one,as a common compound, the synthetic route is as follows.

(S)-4-phenyloxazolidin-2-one (25g), dichloromethane (125 mL) and triethylamine (38 g) were charged into a round bottom flask at room temperature and stirred. To the reactionmixture, DMF (10 mL) and DMAP (5g) were added and stirred. The reaction mass wascooled to 0-5C and added valeryl chloride (23 g). The reaction mass was stirred followedby addition of water (125 mL). The organic layer was separated, washed with HC1 (150mL), sodium bicarbonate solution (150 mL) and distilled under reduced pressure to obtain a residue. To the residue n-Heptane (250 mL) was added under stirring, cooled the reaction mass to 10-15C and filtered. The obtained solid was washed with n-heptane (75 mL), suck dried and dried under vacuum to give the title compound as off-white to pale yellow solid. Yield: 33 g (86%)

99395-88-7, 99395-88-7 (S)-4-Phenyloxazolidin-2-one 730424, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; MICRO LABS LIMITED; KUMAR, Pramod; SANKARESWARAN, Srimurugan; MANNAM, Madhavarao; GADDAM, Venugopal Reddy; CHILUUKURU, Srikanth; CHAUBEY, Bipin Kumar; (43 pag.)WO2018/42393; (2018); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108149-60-6,(S)-(-)-3-tert-Butoxycarbonyl-4-methoxycarbonyl-2,2-dimethyl-1,3-oxazolidine,as a common compound, the synthetic route is as follows.

(iS)-ter/-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate (2). To an ice cold solution of commercially available 1 (35 g, 135 mmol) in THF MeOH (500 mL (95:5)) was added LiBH4 (5.9 g, 271 mmol) portionwise and the suspension was stirred for 2 h at RT. The reaction mixture was cooled and quenched with ice. Solvent was removed under reduced pressure, and water was added. The aqueous layer was extracted with EtOAc, concentrated and chromatographed (EtOAc:hexanes, 3:7) to yield 2 (23 g, 74 % yield).

108149-60-6, 108149-60-6 (S)-(-)-3-tert-Butoxycarbonyl-4-methoxycarbonyl-2,2-dimethyl-1,3-oxazolidine 688221, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; EXELIXIS, INC.; XU, Wei; (106 pag.)WO2017/4608; (2017); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99395-88-7,(S)-4-Phenyloxazolidin-2-one,as a common compound, the synthetic route is as follows.

Method 59; (4S)-3-{[(4-Methoxybenzyl) thio] acetyl}-4-phenyl-1, 3-oxazolidin-2-one; (4-Methoxy-benzylsulfanyl) -acetic acid (1.3 g, 6.1 mmol) was dissolved in dry DCM (40 ml) and cooled to 0C. N, N’-dicyclohexylcarbodiimide (6.1 g, 6.1 mmol) and DMAP (1.6 g, 12.9 mmol) were added and the mixture was stirred for 30 minutes. (S)- (+)-4-Phenyl-2- oxazolidinone (1,0 g, 6.1 mol) was added and the mixture was stirred at room temperature for 24 hours. The mixture was filtrated, concentrated under reduced pressure and purified by flash-chromatography (Hex: EtOAc 8: 2 then 1 : 1). This afforded 1.7 g (77 %) of the title compound as a white solid. NMR (200 MHz) : 3.46-3. 59 (m, 3H), 3.74-3. 76 (m, 4H), 4.23- 4.28 (m, 1H), 4.68 (t, 1H), 5.38-5-42 (m, 1H), 6.78 (d, 2H), 7.14 (d, 2H), 7. 32-7. 40 (m, 5H)., 99395-88-7

The synthetic route of 99395-88-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; WO2005/61452; (2005); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

99395-88-7, (S)-4-Phenyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(4S)-3-{[(4-Methoxybenzyl)thio]acetyl}-4-phenyl-l,3-oxazolidin-2-one[(4-Methoxybenzyl)thio]acetic acid (1.3 g, 6.1 mmol) was dissolved in dry CH2Cl2 (40 ml) and given O0C. N,N’-Dicyclohexylcarbodiimide (DCC, 6.1 g, 6.1 mmol) and 4- EPO (dimethylamino)pyridine (DMAP, 1.6 g, 12.9 mmol) were added and the mixture was stirred for 30 minutes. (S)-(+)-4-Phenyl-2-oxazolidinone (1,0 g, 6.1 mol) was added and the mixture was stirred at room temperature for 24 hours. The mixture was filtrated, concentrated under reduced pressure and purified by flash-chromatography (Hex : EtOAc 8:2 then 1:1). This 5 afforded the title compound as a white solid.1H-NMR (CDCl3, 200 MHz): delta 3.46-3.59 (m, 3H), 3.74-3.76 (m, 4H), 4.23-4.28 (m, IH), 4.68 (t, J = 8.8 Hz, IH), 5.38-5-42 (m, IH), 6.78 (d, /= 8.6 Hz, 2H), 7.14 (d, J = 8.6 Hz, 2H), 7.32-7.40 (m, 5H)

99395-88-7, The synthetic route of 99395-88-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; WO2006/137796; (2006); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99395-88-7,(S)-4-Phenyloxazolidin-2-one,as a common compound, the synthetic route is as follows.

In anhydrous and oxygen-free environment, 36g of 4-[2-(4-fluoro-phenyl)-[1,3]dithiacyclolan-2-yl]-butyric acid (IV) was added and 300ml of dichloromethane was added. ,Add 50ml triethylamine, temperature -20C-10C,A mixture of 20 ml of pivaloyl chloride + 50 ml of tetrahydrofuran is added dropwise.Reaction for 2 hours. Add 6.4g of anhydrous lithium chloride and stir for 2 hours.27g 4-phenyl-2-oxazolidone added,The reaction mixture was stirred for 5-7 h, and extracted and crystallized to obtain Intermediate VI.Yield 96.1%., 99395-88-7

As the paragraph descriping shows that 99395-88-7 is playing an increasingly important role.

Reference£º
Patent; Shandong New Age Pharmaceutical Co., Ltd.; Zhang Guimin; Zang Chao; Xia Mingjun; (14 pag.)CN107488165; (2017); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem