With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.139009-66-8,(S)-N-Boc-2,2-dimethyloxazolidine-4-carboxylic Acid,as a common compound, the synthetic route is as follows.
139009-66-8, General procedure: Diazomethane was prepared by adding dropwise a solution of Diazald in Et2O to a stirring solution of KOH in EtOH and H2O at 65 C. The solution of diazomethane in Et2O (125 mL) was obtained by distillation of the mixture and used immediately. Boc-Tyr(tBu)-OH (10.0 g, 29.7 mmol) was dissolved in anh DCM (25 ml). NMM (8.17 ml, 74.3 mmol) was added and the solution was stirred for 10 min under an Ar atmosphere. The reaction was cooled down to -25 C and a solution of isobutylchloroformate (4.66 mL, 35.6 mmol) in anh DCM (10 mL) was added slowly in 10 min. The reaction was stirred at -25 C for 10 min. The salts formed were filtered and the resulting solution was again stirred at -25 C. The diazomethane (59.4 mmol) solution was added. The reaction was allowed to warm to rt and stirred for 16 h. The mixture was quenched using sat. NH4Cl (10 mL), H2O (10 mL) and 1N HCl (8 mL). The two phases were separated and the aqueous phase was extracted with EtOAc (3 x 25 mL). The combined organic phases were dried (MgSO4) and concentrated under vacuum. The crude compound was purified by flash chromatography on silica gel eluting with EtOAc and hexane (1:4) to yield the title compound as a yellow solid which was used immediately in the next reaction. The alpha-diazoketone obtained (10.4 g, 28.9 mmol) was dissolved in MeOH (150 mL). A solution of silver benzoate (659 mg, 2.89 mmol) in triethylamine (10 mL) was added dropwise at 0 C. The reaction darkened in color and was stirred for 16 h at rt. The resulting mixture was filtered through Celite and was concentrated to 50 mL of solvent under vacuum. The remaining solution was diluted in EtOAc (300 mL) and washed with 1N HCl (3 x 100 mL). The organic phase was dried (MgSO4) and concentrated under vacuum. The mixture was purified by flash chromatography on silica gel eluting with EtOAc and hexane (from 3:17). The title ester was obtained as a white solid (10.8 g, 97 %).
The synthetic route of 139009-66-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Proteau-Gagne, Arnaud; Nadon, Jean-Franois; Bernard, Sylvain; Guerin, Brigitte; Gendron, Louis; Dory, Yves L.; Tetrahedron Letters; vol. 52; 49; (2011); p. 6603 – 6605;,
Oxazolidine – Wikipedia
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