Day: October 19, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80-65-9,3-Aminooxazolidin-2-one,as a common compound, the synthetic route is as follows.,80-65-9

To a screw-cap vial containing 3-aminooxazolidin-2-one (0.05 g) suspended in CH2CI2 (12 mL) cooled to 0 C. Then triethylamine (0.14 mL) was introduced followed by 2-fluoro-4-[5-(trifluoromethyl)- 1,2,4-oxadiazol-3-yl]benzoyl chloride (0.15 g) in one portion. The reaction contents were then poured into a separatory funnel and diluted with CH2CI2 and water. The organic layer was separated and thenwashed with 1 N HCI, 1 N NaOH, and brine. The solvent was removed under reduced pressure and the crude residue was purified by flash chromatography over silica gel (heptane:ethyl acetate gradient) togive the title compound as a white solid (mp: 186- 189C). 1H NMR (400 MHz, CDCI3): oe 8.60 (d, 1H),8.32 (d, 1H), 8.10 (d, 1H), 7.97 (d, 1H), 4.55 (t, 2H), 4.00 (t, 2H). LC/MS retention time = 0.85 minutes,361 (M+H)

80-65-9 3-Aminooxazolidin-2-one 65725, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; STIERLI, Daniel; HOFFMAN, Thomas, James; BOU HAMDAN, Farhan; (82 pag.)WO2017/157962; (2017); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

875444-08-9, (4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

875444-08-9, To a solution of (45′,5J?)-5-[3}5-bis(trifluoromethyl)phenyl]-4-methyl-li3-oxazoIidin-2-one (4.94 g, 15.77 mmol) in THF (75 mL) was added NaH (60% dispersion in mineral oil) (0.526 g, 13.14 mmol). After stirring the reaction at room temperature for 10 minutes, 3-bromo-2- (bromomethyl)-6-chloropyridine (3.0 g, 10.51 mmol) was added as a solution in THF (20 mL). The reaction was stirred at room temperature for 16 hours and then quenched with saturated NH4CI (40 mL). The mixture was diluted with EtOAc (100 mL) and hexanes (50 mL). The organic layer was washed with water (2 x 100 mL) and brine (50 mL), dried over Na2S0 , filtered, and concentrated. Purification of the residue by flash chromatography on silica gel with 0 to 50% EtOAc/hexanes afforded (4555^)-5-[3,5-bis(trifiuoromethyl)phenyl]-3-t(3-bromo-6- chloropyridin-2-yl)methyl]-4-methyl-1,3-oxazolidin-2-one. LCMS = 518.8 (M+H)+ 1H MR (CD<, 500 MHz) delta 7.90 (s, 1H), 7.81-7.83 (m, 3H), 7.18 (d, J- 8.5 Hz, 1H), 5.87 (d, J- 8.5 Hz, 1H), 5.02 (d, J= 17.2 Hz, 1H)5 4.42 (m, IE), 4.32 (d, J= 17.1 Hz, 1H), 0.80 (d, J= 6.6 Hz, 3H). 875444-08-9 (4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one 23583229, aoxazolidine compound, is more and more widely used in various fields. Reference£º
Patent; MERCK SHARP & DOHME CORP.; LU, Zhijian; CHEN, Yi-Heng; SMITH, Cameron; LI, Hong; THOMPSON, Christopher, F.; SWEIS, Ramzi; SINCLAIR, Peter; KALLASHI, Florida; HUNT, Julianne; ADAMSON, Samantha, E.; DONG, Guizhen; ONDEYKA, Debra, L.; QIAN, Xiaoxia; SUN, Wanying; VACHAL, Petr; ZHAO, Kake; WO2012/58187; (2012); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.695-53-4,5,5-Dimethyloxazolidine-2,4-dione,as a common compound, the synthetic route is as follows.

695-53-4, (b) A mixture of 4 (0.11 g, 0.77 mmol), 2 (0.10 g, 0.77 mmol), anhydrous NiCl2 (0.1 g, 0.8 mmol), urea (0.6 g, 10 mmol), and a catalytic amount of MOA was ground into a homogeneous mixture, which was transferred to a test tube and reacted at 250 C for 10 min. After cooling to room temperature, the residue was ground, and washed successively with hot water and hot 50% ethanol until the washings were colorless. The purification procedures described above afforded 8 mg of 3 (5.6%).

As the paragraph descriping shows that 695-53-4 is playing an increasingly important role.

Reference£º
Article; Dudkin, Semyon V.; Makarova, Elena A.; Fukuda, Takamitsu; Kobayashi, Nagao; Lukyanets, Evgeny A.; Tetrahedron Letters; vol. 52; 23; (2011); p. 2994 – 2996;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

2346-26-1, Oxazolidine-2,4-dione is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2.90 g (12.99 mmol) of 4′-(2-hydroxyethyl)-3-biphenylcarbonitrile, prepared in step 11.1., 2.7 ml (14.29 mmol) of triethylamine and 0.15 g (1.30 mmol) of 4-dimethylaminopyridine in 30 ml of dichloromethane, cooled with an ice bath, is admixed with 1.1 ml (14.29 mmol) of methanesulphonyl chloride. The mixture is subsequently stirred at ambient temperature for 2 hours. 100 ml of dichloromethane and 30 ml of saturated aqueous sodium chloride solution are added. The organic phase is separated off after settling, dried over sodium sulphate and evaporated to dryness to give 3.5 g of product in the form of an oil. The product is redissolved in 60 ml of tetrahydrofuran, and 1.40 g (13.94 mmol) of 1,3-oxazolidine-2,4-dione and 2.87 ml (23.23 mmol) of 1,1,3,3-tetramethylguanidine are added. The mixture is heated at 70 C. overnight. It is evaporated to dryness. The residue is taken up in a mixture of ethyl acetate and saturated aqueous sodium chloride solution. The organic phase is separated off after settling, dried over sodium sulphate and evaporated to dryness. The residue is purified by chromatography on silica gel, eluting with a 60/40 then 50/50 mixture of cyclohexane and ethyl acetate, to give 3.3 g of product in the form of a white solid. Melting point ( C.): 121-123

2346-26-1, 2346-26-1 Oxazolidine-2,4-dione 97389, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; Sanofi-Aventis; US2006/14830; (2006); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90719-32-7,(S)-4-Benzyloxazolidin-2-one,as a common compound, the synthetic route is as follows.

90719-32-7, EXAMPLE 5; Preparation of (S)-4-benzyl-3-(3-methylbutanoyl)oxazolidin-2-one, compound; 4-Dimethylaminopyridine (2.55 g, 21 .3 mmol) and triethylamine (46.9 ml, 340.8 mmol) in dichloromethane (100 ml) are added to a solution of (S)-(-)-4- benzyl-2-oxazolidinone (37.7g, 213 mmol) in dichloromethane (300 ml). Next, isovaleroyi chloride (33.75 ml, 207 mmol) in dichloromethane (50 ml) is added to the previously prepared mixture and cooled to 0 C keeping the internal temperature below 10 C. The reaction mixture is stirred for 30 minutes at 10 C, then the formed salts are filtered. Water (100 ml) is added and the phases are separated. The organic phase is washed with water (100 ml) and brine (100 ml), dried over sodium sulphate and evaporated to dryness obtaining 53 g of a yellow oil, which solidifies over time (yield 95%).1 H NMR (300 MHz, CDCI3, 298K) delta 7.35-7.15 (m, 5H), 4.71 -4.61 (m, 1 H), 4.21 – 4.10 (m, 2H), 3.35-3.25 (dd, J = 13.2, J = 3.4 Hz.1 H), 2.85-2.72 (dd, J = 14.97 Hz, 6.8 Hz, 1 H), 2.80-2.67 (m, 2H), 2.29-2.12 (sept, J=13.2 Hz.1 H), 1 .03-0.98 (d, J = 6.8 Hz.3H), 0.98-0.95 (d, J = 6.8 Hz, 3H).13C NMR (75 MHz, CDCI3, 298K) delta 175.6, 171 .2, 154.4, 137.1 , 130.5, 130.2, 126.0, 82.1 , 66.1 , 45.6, 42.6, 41 .4, 34.0, 28.7, 27.3, 19.7.

As the paragraph descriping shows that 90719-32-7 is playing an increasingly important role.

Reference£º
Patent; CHEMO IBERICA, S.A.; TADDEI, Maurizio; RUSSO, Adele; CINI, Elena; RIVA, Renata; RASPARINI, Marcello; CARCONE, Luca; BANFI, Luca; VITALE, Romina; ROSEBLADE, Stephen; ZANOTTI-GEROSA, Antonio Carlo; WO2011/151442; (2011); A2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

17016-83-0, (S)-4-Isopropyl-2-oxazolidinone is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (S) -4-isopropyloxazolidin-2-one (5.00 g, 38.7 mmol, 1.0 eq. ) in anhydrous THF (200 mL) at -78 was added n-BuLi (2.5 M in hexanes, 17.0 mL, 1.2 eq. ) in 30 min under N2. The mixture was stirred at -78 for 1 h, and then propionyl chloride (4.0 mL, 42.58 mmol, 1.1 eq. ) was added dropwise. After the mixture was stirred at -78 for another 1 h, TLC analysis indicated the reaction completed. Saturated ammonium chloride solution (250 mL) was added and extracted with EtOAc (3 ¡Á 100 mL) . The combined organic layers were washed with 1N NaOH solution (200 mL) and brine (300 mL) , dried over anhydrous Na2SO4, filtered, concentrated and purified by column chromatography (7: 1 hexanes/EtOAc) to give compound 114 as a colorless oil (6.36 g, 89%yield) . MS ESI m/z calcd for C9H16NO3[M+H]+186.10, found 186.10.1H NMR (400 MHz, CDCl3) delta 4.48 -4.39 (m, 1H) , 4.27 (t, J = 8.7 Hz, 1H) , 4.21 (dd, J = 9.1, 3.1 Hz, 1H) , 3.06 -2.82 (m, 2H) , 2.38 (dtd, J = 14.0, 7.0, 4.0 Hz, 1H) , 1.17 (t, J = 7.4 Hz, 3H) , 0.90 (dd, J = 17.0, 7.0 Hz, 6H) .

17016-83-0, 17016-83-0 (S)-4-Isopropyl-2-oxazolidinone 7157133, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; HANGZHOU DAC BIOTECH CO. LTD; ZHAO, Robert Yongxin; YANG, Qingliang; HUANG, Yuanyuan; ZHAO, Linyao; GAI, Shun; YE, Hangbo; LEI, Jun; XU, Yifang; CAO, Mingjun; GUO, Huihui; JIA, Junxiang; TONG, Qianqian; LI, Wenjun; ZHOU, Xiaomai; XIE, Hongsheng; BAI, Lu; CAI, Xiang; ZHUO, Xiaotao; ZHANG, Xiuzheng; ZHENG, Jun; (424 pag.)WO2019/127607; (2019); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108149-63-9,(R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate,as a common compound, the synthetic route is as follows.

To a dry THF solution (30 mL) of alcohol 2 (3 g, 12.97 mmol) was addedNaH (0.985 g of 60% dispersion in mineral oil, 24.64 mmol) and then MeI wasadded drop wise (1.6 mL, 25.94 mmol), and the mixture was stirred at roomtemperature for 30 min. After the reaction was complete (TLC), it was cooled onan ice bath and quenched by slowly adding cold water (30 mL). The mixture wasextracted with dichloromethane (3 X 40 mL). The combined organic layers weredried over anhydrous Na2SO4.After concentration of the combined organic layers,the residual oil was subjected to flash chromatography (CombiFlash Rf 200i, Teledyne Isco) using RediSep silica gel column (12 g) eluting with petroleumether-EtOAc (9:1, isocratic) to furnish methyl ether 3 as a colourless liquid (2.8 g, 88%); Rf0.35(10% EtOAc in petroleum ether); [alpha]D25 -46.6 (c 1.03, CHCl3) [Lit. [alpha]D25-42.4 (c 1.37, CHCl3)10]; IR (CHCl3) umax: 3370, 3017, 2934, 1688,1464, 1387, 1252, 1217, 1168, 1095, 1030, 851, 766, 668 cm-1; 1HNMR (400 MHz, CDCl3) delta: 4.04-3.88 (m, 3H), 3.50 (m, 1H), 3.37(s, 3H), 3.34-3.26 (m, 1H), 1.61-1.44 (m, 15H); 13C NMR (100 MHz, CDCl3) delta: 152.2,151.7, 93.7, 93.3, 80.3, 79.8, 72.1, 71.3, 65.6, 65.3, 59.0, 58.9, 56.3, 56.1,28.4, 28.4, 27.5, 26.7, 24.3, 23.0; HRMS (ESI): m/zcalcd for C12H23NO4Na [M + Na]+268.1519; found: 268.1506.

108149-63-9, 108149-63-9 (R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate 11053464, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Article; Aratikatla, Eswar K.; Bhattacharya, Asish K.; Tetrahedron Letters; vol. 56; 42; (2015); p. 5802 – 5803;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

80-65-9, 3-Aminooxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

80-65-9, A. 3-[(4-Chromanylidene)amino]-2-oxazolidinone A 62 g (0.61 mole) portion of 3-amino-2-oxazolidinone was charged in a 500 ml, 3-necked flask equipped with a thermometer, stirrer and reflux condenser, and treated successively with 92 ml of H2 O, 8 ml of 10% HCl and 42 g (0.28 mole) of 4-chromanone in 200 ml of ethanol. The reaction mixture was refluxed for 36 hrs., stripped in vacuo to one-half volume and cooled in the refrigerator overnight. The slurry was filtered and the white crystalline solid washed with 50 ml of isopropanol then 200 ml of ether and dried; m.p. 105-108. Yield: 44 g (68%). The filtrate was extracted with 250 ml of CHCl3, and the CHCl3 extract dried over MgSO4, filtered and stripped in vacuo.

The synthetic route of 80-65-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Morton-Norwich Products, Inc.; US4108862; (1978); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

80-65-9, 3-Aminooxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,80-65-9

General procedure: Following the addition of 4-(4-fluorophenoxy) butyric acid (0.71 g, 3.6 mmol) to 20 mL ofdichloromethane in a 50 mL three-necked round-bottom flask, thesolution was agitated until dissolution. Subsequently, EDCI (0.85 g,4.44 mmol) HOBt (0.6 g, 4.44 mmol) and triethylamine (0.84 g,9.25 mmol) were added in turn at 0 C. Stirring in an ice bath for 1 h,3-amino-2-oxazolidinone (0.37 g, 3.6 mmol) was added again. Thesolutionwas brought to 25 C and stirred overnight. Following TLC,the product was filtered by vacuum and dried under rotary evaporation.The product was a white solid weighing 0.51 g with a yieldof 50.2%.

The synthetic route of 80-65-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jiang, Kai; Yan, Xinlin; Yu, Jiahao; Xiao, Zijian; Wu, Hao; Zhao, Meihua; Yue, Yuandong; Zhou, Xiaoping; Xiao, Junhai; Lin, Feng; European Journal of Medicinal Chemistry; vol. 194; (2020);,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17016-83-0,(S)-4-Isopropyl-2-oxazolidinone,as a common compound, the synthetic route is as follows.

To a solution of (5)-4-isopropyl-2-oxazolidonone (1.56 g, 12.1 mmol, 1 equiv) in THF (40 ml) at -78 0C was added M-butyllithium (4.84 ml of a 2.5 M solution in hexanes, 12.1 mmol, 1 equiv). After 15 min acid chloride 8 (2.14 g, 13.3 mmol, 1.1 equiv) was added and the mixture was stirred for 30 min at -78 0C and for 15 min at 0 0C. Saturated aqueous ammonium chloride (10 ml) was added and the resulting slurry was concentrated in vacuo. The residue was diluted with ether and washed successively with saturated aqueous sodium bicarbonate and brine. The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. Purification by flash chromatography (10% EtOAc/hexanes) gave imide 9 ( 2.94 g, 96%) as a colorless oil: [alpha]22D = +66.7 (c= 0.6, CHCl3); TLC R/= 0.40 (silica gel, 25% EtOAc/hexanes); 1H NMR (600 MHz, CDCl3) delta 4.68 (s, IH), 4.66 (s, IH), 4.43-4.40 (m, IH), 4.25 (t, J= 9.0 Hz, IH), 4.19 (dd, J= 3.0 Hz, 9.0 Hz, IH), 3.01- 2.83 (m, 2H), 2.38-2.32 (m, IH), 2.02 (t, J= 7.8 Hz, 2H), 1.69 (s, 3H), 1.67-1.61 (m, 2H), 1.51-1.46 (m, 2H), 0.90 (d, J= 7.2 Hz, 3H), 0.85 (d, J= 7.2 Hz, 3H); 13C NMR (IOO MHz, CDCl3) delta 173.5, 154.3, 145.8, 110.2, 63.6, 58.6, 37.7, 35.6, 28.6, 27.2, 24.3, 22.6, 18.2, 14.9; HRMS calcd for C4H23NO3 + Na+ 276.1576; found 276.1567 [M + Na+]., 17016-83-0

As the paragraph descriping shows that 17016-83-0 is playing an increasingly important role.

Reference£º
Patent; UNIVERSITY OF TOLEDO; WO2008/118327; (2008); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem