Day: September 27, 2020

16251-45-9, (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 38 [4S-(4alpha,5alpha)]3-(3-Furan-2-yl-propionyl)-4-methyl-5-phenyl-oxazoldin-2-one Compound 29 (11.66 g, 83.19 mmol) was dissolved in THF (190 ML) and cooled in an ice bath.. triethyl amine (43.5 ML, 312.1 mmol) was added, followed by the trimethylacetyl chloride (15.4 ML, 125.0 mmol).. The reaction was stirred at 0 C. for 2 hours, and the LiCl (3.879 g, 91.5 mmol), (4S,5R)-(-)-4-methyl-5-phenyl-2-oxazolidinone (15.02 g, 84.76 mmol), and THF (70 ML) were added.. The reaction was stirred at room temperature overnight.. The solids were filtered, washed with EtOAc, and the filtrate and washings rotovapped to give a brown colored suspension.. The solids were filtered, washed with EtOAc, and the filtrated rotovapped.. The crude material was chromatographed on silica eluding with 10% EtOAc/hexanes to give the title compound 38 (19.967 g, 80%) as an off-white solid. 1H NMR (400 MHz, CDCl3) delta7.42-7.33 (m, 3H), 7.29-7.24 (m, 3H), 6.26 (m, 1H), 6.04 (d, 1H, J=3.17), 5.65 (d, 1H, J=7.33 Hz), 4.74 (q, 1H, J=6.8 Hz), 3.35-3.21 (m, 2H, 3.01 (t, 2H, J=7.4 Hz), 0.87 (d, 3H, J=6.59 Hz). MS (APCI) m/z 300 (M++1). Analysis calculated for C17H17NO4: C, 68.22; H, 5.72; N, 4.68. Found: C, 68.34; H, 5.81; N, 4.63. [alpha]D=-39.5 (c=1 in CHCl3).

16251-45-9, As the paragraph descriping shows that 16251-45-9 is playing an increasingly important role.

Reference£º
Patent; Warner-Lambert Company; US6710190; (2004); B1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2346-26-1,Oxazolidine-2,4-dione,as a common compound, the synthetic route is as follows.

Example 11 A mixture of (E)-4-[2-[5-methyl-2-(2-naphthyl)-4-oxazolyl]vinyl]cinnamaldehyde (2.00 g), 2,4-oxazolidinedione (1.11 g), piperidine (0.23 g), ethanol (100 ml) and tetrahydrofuran (50 ml) was refluxed under heating conditions for 8 hours. After the reaction mixture was concentrated, chloroform was added to the residue; the mixture was then washed with 2N HCl and water. The organic layer was washed with water, dried (MgSO4) and then concentrated. The residue was subjected to silica gel column chromatography. The crystal obtained from the fraction eluted with ethyl acetate-chloroform (1:9, v/v) was dissolved in tetrahydrofuran (100 ml), and subjected to catalytic hydrogenation at 1 atm and room temperature in the presence of palladium-carbon (5%, 0.5 g). After the catalyst was filtered off, the filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to yield 5-[3-[4-[2-[5-methyl-2-(2-naphthyl)-4-oxazolyl]ethyl]phenyl]propyl]-2,4-oxazolidinedione (0.29 g, 12%) from the fraction eluted with methanol-chloroform (2:98, v/v), which was then recrystallized from dichloromethane-isopropyl ether to yield a colorless prisms having a melting point of 168-169 C.

2346-26-1, The synthetic route of 2346-26-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; US5614544; (1997); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

2346-26-1, Oxazolidine-2,4-dione is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

WORKING EXAMPLE 23 In substantially the same manner as in Working Example 11, 4-methoxy-3-(5-methyl-2-phenyl-4-oxazolyl-methoxy)cinnamaldehyde was condensed with 2,4-oxazolidinedione. The condensate was subjected to catalytic reduction to yield 5-[3-[4-methoxy-3-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]propyl]-2,4-oxazolidinedione, which was recrystallized from chloroform-methanol to give colorless prisms, m.p.185-187 C.

2346-26-1, 2346-26-1 Oxazolidine-2,4-dione 97389, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; US5932601; (1999); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

452339-73-0, (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Sodium hydride (60% oil dispersion, 1.4g) was added to a stirred solution of (5R)- (2, 2- DIMETHYL-4H-1, 3-BENZODIOXIN-6YL)-1, 3OXAZOLIDIN-2-ONE (6. 0G) in dry dimethylformamide (80ML) at 0 under nitrogen. After 20 min a solution of 1- {4- [ (6-BROMOHEXYL) oxy] butyl}-4- iodobenzene (12.6g) in dry dimethylformamide (30ML) was added dropwise. The mixture was stirred for 15h at ambient temperature. The mixture was poured into an aqueous ammonium chloride solution (700MI) and extracted into ethyl acetate. The organic extracts were washed with water, dried (NA2SO4) and evaporated. Purification by chromatography on a biotage cartridge (90g) using ether-petroleum ether (40-60) (4: 1) gave the title compound as a clear oil (10G). LCMS RT = 4.19 min.

452339-73-0, As the paragraph descriping shows that 452339-73-0 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/39762; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2346-26-1,Oxazolidine-2,4-dione,as a common compound, the synthetic route is as follows.

)._A solution of the solid from above (500 mg, 5.00 mmol), benzyl chloride (0.569 mL, 5.00 mmol), and TEA (0.69 mL, 5.00 mmol) in CHC13 (5.00 mL) was stirred at 60 C for 48 hours . EtOAc (50.0 mL) and 1M aq HCl (50.0 mL) were added. The aq phase was extracted with CHC13 (3X50 mL), and the combined organic phases were washed with brine (50 mL), dried over MgS04, filtered, and concentrated under reduced pressure to provide the title compound as a solid (0.894 g, 95%) 1H NMR (300 MHz, CDC13) delta 7.44-7.28 (m, 5H), 4.68 (s, 2H), 4.67 (s, 3H)., 2346-26-1

2346-26-1 Oxazolidine-2,4-dione 97389, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; EPIGENETIX, INC.; ALBERT, Jeffrey, S.; JOHNSTONE, Shawn; JONES, Paul; WO2014/152029; (2014); A2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

153652-70-1, (4S,5R)-3-Benzoyl-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Solution OF 2-CHLOR-4, 6-DIPHENOXY-1, 3,5-triazine (CDPHT) (0. 3 g, 1 mmole) in 5 mi THF was mixed with N-methylmorpholine (0.11 ml, 1 mmole) for 30 minutes at temperature of 0-5C to obtain N- (4, 6- DIPHENOXY-1, 3, 5-triazine-2-yl)-N- methylmorpholine chloride. Then, phenyl isoserine derivative with the formula 4b, where R3= R4=CH3 (0.325 g, 1 mmol) was added and mixed for 12 hours. After N-METHYLMORPHOLINE HYDOCHLORIDE was filtered off, and solvent was evaporated it gave respective triazine ester of the formula 6b, where R3= R4=CH3, and R5=R6= OCEHG, with the quantitative yield. TLC: eluent CHCI3, RR0. 65 1H-NMR (CDCI3) : 6=1. 76 (s, 3H); 1.79 (s, 3H) ; 5.19 (d, J=8.0 Hz, 1H); 5.27 (d, J= 8. 0 Hz, 1H) ; 7.19-7. 22 (m, 2H); 7.40-7. 74 (m, 18 H) ppm] JR (KBr): 1780 [CM~1] The triazine ester, in the presence of magnesium bromide and PYROLIDINPYRIDINE, was coupled with protected Baccatin III of the generalized formula 3, where R2=Si (C2H5) 3. The product was chromatographically and SPECTRALLY identical to that described in the 11. Example.

153652-70-1, The synthetic route of 153652-70-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AGROPHARM S.A.; WO2004/56790; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

2346-26-1, Oxazolidine-2,4-dione is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1.64 g (5.70 mmol) of 5-(naphth-1-yl)pent-4-yn-1-yl methanesulphonate, obtained in stage 3.2., and 0.72 g (7.1 mmol) of 1,3-oxazolidine-2,4-dione are dissolved in 9 ml of tetrahydrofuran. 1.3 g (11.4 mmol) of 1,1,3,3-tetramethylguanidine in solution in 3 ml of tetrahydrofuran are added. The mixture is heated at reflux overnight. 25 ml of ethyl acetate and 6 g of silica are added. The mixture is evaporated to dryness. The residue is purified by chromatography on silica gel, elution being carried out with a 90/10 and then 80/20 and 70/30 mixture of cyclohexane and of ethyl acetate, to produce 1.33 g of product in the form of a white solid. M.p. ( C.): 99-101 C.

2346-26-1, 2346-26-1 Oxazolidine-2,4-dione 97389, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; SANOFI-AVENTIS; US2007/21426; (2007); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108149-63-9,(R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate,as a common compound, the synthetic route is as follows.

a) (R)-2,2-Dimethyl-4-phenoxymethyl-oxazolidine-3-carboxylic acid tert-butyl ester To a stirred solution of tert-butyl (R)-4-(hydroxymethyl)-2,2-dimethyl-3- oxazolidinecarboxylate (400 mg; CAS 108149-63-9) in THF (20 ml) were added phenol (197 mg), triphenylphosphine (573 mg) and di-tert-butyl azodicarboxylate (488 mg). The resulting yellow solution was stirred at 70 0C for 18 h overnight, then concentrated in vacuo. The crude product was purified by column chromatography (SiO2; gradient: heptane/EtOAc 100:0 -> 70:30) to give (R)-2,2-dimethyl-4-phenoxymethyl-oxazolidine- 3-carboxylic acid tert-butyl ester (336 mg, 63%) as a colourless viscous oil. MS (ISP): 308.3 ([M+H]+))., 108149-63-9

The synthetic route of 108149-63-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/92785; (2008); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.695-53-4,5,5-Dimethyloxazolidine-2,4-dione,as a common compound, the synthetic route is as follows.

695-53-4, 13-1) Production of 5,5-dimethyl-3-(2-nitrobenzyl)oxazolidine-2,4-dione A mixture of 5,5-dimethyloxazolidine-2,4-dione (1.9 g, 15 mmol), 2-nitrobenzylchloride (2.6 g, 15 mmol), potassium carbonate (2.5 g, 18 mmol) and N, N-dimethylformamide (15 ml) was heated at 80C for 2 hours while stirring. After cooling, the reaction mixture was mixed with water and extracted with ethyl acetate, and the organic layer was washed with water (twice), then with saturated sodium chloride solution and dried with anhydrous magnesium sulfate. After concentrated under reduced pressure, the organic layer was mixed with hexane, and precipitated solid material was collected by filtration to obtain 5,5-dimethyl-3-(2-nitrobenzyl)oxazolidine-2,4-dione (3.7 g). Yield: 93% Properties: melting point 133.5-134.5C

695-53-4 5,5-Dimethyloxazolidine-2,4-dione 3081, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; NIHON NOHYAKU CO., LTD.; EP1852425; (2007); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

2346-26-1, Oxazolidine-2,4-dione is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 2 A mixture of 4-[3-(5-methyl-2-phenyl-4-oxazolyl)propionyl]cinnamaldehyde (3.60 g), 2,4-oxazolidinedione (1.58 g), piperidine (0.27 g) and acetic acid (30 ml) was heated under refluxing conditions for 6 hours. The reaction mixture was cooled; the resulting crystal of 5-[4-[3-(5-methyl-2-phenyl-4-oxazolyl)propionyl]cinnamylidene]-2,4-oxazolidinedione was collected by filtration and washed with ether-methanol. The filtrate and washings were combined together and concentrated under reduced pressure; chloroform was added to the residue., 2346-26-1

2346-26-1 Oxazolidine-2,4-dione 97389, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; US5614544; (1997); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem