Day: September 22, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.152305-23-2,(S)-4-(4-Aminobenzyl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.

Example 1 Synthesis of (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one hydrochloride (IIIa) A mixture of (S)-4-(4-aminobenzyl)-1,3-oxazolidin-2-one (100 gms) and concentrated hydrochloric acid (250 ml) in water (500 ml) was treated with an 50percent aqueous solution of sodium nitrite (46 gms) at ?5 to 10¡ã C. Upon completion of the reaction, as monitored by TLC, the reaction mass was further treated with stannous chloride dihydrate (420 gms) dissolved in concentrated hydrochloric acid (500 ml ) and water (544 ml ) at ?15 to 10¡ã C. When the reaction was complete, as monitored by HPLC, the pH of the reaction mass was adjusted in the range of 2.0 to 6.0 by adding aqueous sodium hydroxide solution. The reaction mass was cooled and filtered to separate the solid. The aqueous layer was extracted with dichloromethane and further made alkaline in the pH range of 6.0 to 10.0 with aqueous sodium hydroxide. The mixture was cooled and filtered to give solid (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one (III), which was then suspended in isopropanol (420 ml) and converted to the hydrochloride salt by treatment with hydrogen chloride at reflux temperature to yield the hydrochloride salt of (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one (IIIa). Yield: 85 g Purity (HPLC)?99percent

152305-23-2, The synthetic route of 152305-23-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; EMCURE PHARMACEUTICALS LIMITED; Gurjar, Mukund Keshav; Kaliaperumal, Neelakandan; Ahirrao, Pravin Prabhakar; Baireddy, Raghuramireddy; Balasubramanian, Prabhakaran; Nandala, Srinivas; Panchabhai, Prasad Pandurang; Mehta, Samit Satish; US2014/228582; (2014); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80-65-9,3-Aminooxazolidin-2-one,as a common compound, the synthetic route is as follows.

80-65-9, General procedure: Following the addition of 4-(4-fluorophenoxy) butyric acid (0.71 g, 3.6 mmol) to 20 mL ofdichloromethane in a 50 mL three-necked round-bottom flask, thesolution was agitated until dissolution. Subsequently, EDCI (0.85 g,4.44 mmol) HOBt (0.6 g, 4.44 mmol) and triethylamine (0.84 g,9.25 mmol) were added in turn at 0 C. Stirring in an ice bath for 1 h,3-amino-2-oxazolidinone (0.37 g, 3.6 mmol) was added again. Thesolutionwas brought to 25 C and stirred overnight. Following TLC,the product was filtered by vacuum and dried under rotary evaporation.The product was a white solid weighing 0.51 g with a yieldof 50.2%.

80-65-9 3-Aminooxazolidin-2-one 65725, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Article; Jiang, Kai; Yan, Xinlin; Yu, Jiahao; Xiao, Zijian; Wu, Hao; Zhao, Meihua; Yue, Yuandong; Zhou, Xiaoping; Xiao, Junhai; Lin, Feng; European Journal of Medicinal Chemistry; vol. 194; (2020);,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

139009-66-8, (S)-N-Boc-2,2-dimethyloxazolidine-4-carboxylic Acid is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 7-amino-6-methoxy-2-(l-methyl-lH-pyrazol-4-yl)-3-(3,4,5- trimethoxybenzoyl)benzo[Z>]furan (entry 21, Table 1) (0.08 Ig, 0.185 mmol), 2,2-dimethyl- 3-(l,l-dimethylethyl-4S-3,4-ozazolidinedicarboxylic acid (0.067g, 0.27 mmol) and N,N- diisopropylethylamine (0.08 ml, 0.46 mmol) in anhydrous CH2Cl2 (1 ml) PyBroP (0.128g, 0.46 mmol) was added at room temperature under N2. The resulting mixture was stirred for Ih at room temperature, than diluted to 15 ml with ethyl acetate and washed with 10% aqueous citric acid (1 ml), water, brine and dried over anhydrous MgSO4 and filtered off. The filtrate was evaporated to dryness under reduced pressure and the residue was purified by flash column chromatography (silica-gel, CH2Cl2/ ethyl acetate 9:1) giving the title compound (0.106g, 87%) as a creamy solid. 1H NMR (300 MHz, CDCl3) 8.09 (s, IH), 7.93 (s, IH), 7.13 (s, 2H), 7.03 (d, J = 8.75 Hz, IH), 6.8 (d, J = 8.75 Hz, IH), 4.1 -4.7 (broad m, 2H), 3.91 (s, 3H), 3.89 (s, 3H), 3.87 (s, 3H), 3.82 (s, 3H), 3.77 (s, 6H), 3.33 (m, IH), 1.23 – 1.7 (m, 14H)., 139009-66-8

139009-66-8 (S)-N-Boc-2,2-dimethyloxazolidine-4-carboxylic Acid 6932187, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; ILIAD CHEMICALS PTY LTD; WO2006/84338; (2006); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

131685-53-5, (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

TiCl3(OiPr) was first prepared using dry glassware under N2. A solution of 1 M TiCl4 in dichloromethane (3.4 mmol, 3.4 mL) was cooled to 0 C, and Ti(OiPr)4 (1.1 mmol, 0.34 mL) was added dropwise over 5 min. The solution was diluted with anhydrous dichloromethane (3.5 mL) and stirred at 0 C for 15 min. Meanwhile, compound 25a (1.0 g, 4.3 mmol) was dissolved in anhydrous dichloromethane (14 mL) in dry glassware under N2, and DIEA (0.79 mL) was added dropwise over 5 min, with stirring, at room temperature and then cooled to 0 C. The TiCl3(OiPr) solution was added to the 25a solution dropwise over 25 min. The TiCl3(OiPr) flask was rinsed with anhydrous dichloromethane (2 mL), and the rinse added to the combined flask. The solution was stirred at 0 C for 30 min, and then acrylonitrile (0.43 mL, 6.5 mmol) was added dropwise over 10 min, and this solution stirred at 0 C for 4 h. The reaction was quenched with the addition of saturated NH4Cl (25 mL) and H2O (15 mL), and the aqueous layer was extracted with diethyl ether (3 ¡Á 40 mL). The organic extracts were combined and washed with saturated NaHCO3 (55 mL) followed by brine (55 mL), dried over MgSO4 and concentrated in vacuo to yield a yellow oil. The oil was purified using the Flash+ system and a mobile phase of 3:7 ethyl acetate-hexanes (Rf = 0.30), to yield 26a as a very slightly yellow oil (890 mg, 72% yield). 1H NMR (500 MHz, CDCl3): delta 7.35 (dd, J1 = 7.6 Hz, J2 = 7.1 Hz, 2H), 7.30 (d, J = 7.3 Hz, 1H), 7.21 (d, J = 7.1 Hz, 2H), 4.69 (m, 1H), 4.20 (m, 2H), 3.83 (sextet, J = 6.9 Hz, 1H), 3.31 (dd, J1 = 13.4 Hz, J2 = 3.2 Hz, 1H), 2.78 (dd, J1 = 13.3 Hz, J2 = 3.6 Hz, 1H), 2.41 (dt, J1 = 7.7 Hz, J2 = 1.2 Hz, 2H), 2.19 (m, 1H), 1.81 (m, 1H), 1.24 (d, J = 6.9 Hz, 3H).

131685-53-5, As the paragraph descriping shows that 131685-53-5 is playing an increasingly important role.

Reference£º
Article; Girnys, Elizabeth A.; Porter, Vanessa R.; Mosberg, Henry I.; Bioorganic and Medicinal Chemistry; vol. 19; 24; (2011); p. 7425 – 7434;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.497-25-6,Oxazolidin-2-one,as a common compound, the synthetic route is as follows.,497-25-6

[0528] General Procedure for Goldberg Reaction [0529] This protocol was performed according to conditions disclosed in Org. Lett. 2003, 5 (7), 963. [0530] To a suspension of copper(I) iodide (0.354 g, 1.86 mmol), potassium carbonate (7.35 g, 53.2 mmol) and (¡À)-trans-1,2-diaminocyclohexane (0.328 ml, 2.67 mmol) in dioxane, (15 ml) 9 (5 g, 26.7 mmol) and 10b (2.352 g, 27.01 mmol) were added and the reaction mixture was stirred at 100 C. for 20 h. Reaction mixture was cooled and filtered through silica gel pad with the help of EtOAc (150 ml). Filtrate was concentrated in vacuo to 11b 4.7 g (91%) [0531] Analogous coupling reactions performed according to the above procedure and utilising the appropriate coupling partners according to the schemes gave the following yields: 11a (81%), 11c (40%), 11d (55%), 24a (74%), 24b (64%) [0532] *The above reaction also works under the microwave conditions at 110 C. in 4 h to give 11 (50-90%).

As the paragraph descriping shows that 497-25-6 is playing an increasingly important role.

Reference£º
Patent; Cambridge Enterprise Limited; Kapadnis, Prashant Bhimrao; Glen, Robert; Hiley, Robin; Bell, James; Spring, David; US2013/53372; (2013); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.497-25-6,Oxazolidin-2-one,as a common compound, the synthetic route is as follows.

497-25-6, Intermediate 46:2-[(frans-4-hydroxycyclohexyl)amino]-6-{[6-(2-oxo-1 ,3-oxazolidin-3-yl)-1 ,3- benzothiazol-2-yl]amino}-4-pyridinecarbaldehyde Under an atmosphere of nitrogen, a mixture of 2-[(6-bromo-1 ,3-benzothiazol-2-yl)amino]- 6-[(trans-4-hydroxycyclohexyl)amino]-4-pyridinecarbaldehyde [intermediate 44] (100mg, 0.224mmol) , 1 ,3-oxazolidin-2-one (58.4mg, 0.671 mmol), caesium carbonate (146mg, 0.45mmol) and copper(l) iodide (85mg, 0.45mmol) in dry Nu,Nu-dimethylformamide (3ml_) was thoroughly degassed by the repeated alternate application of vacuum and nitrogen pressure, then treated with Nu,Nu’-dimethylethylenediamine (0.095ml_, 0.89mmol) and heated at 1 10C for 1 hour. The mixture was cooled to ambient temperature, filtered and evaporated to dryness. The product was purified by chromatography on silica from 0 to 15% methanol in dichloromethane to afford the title compound (98mg, 0.216mmol, 97% yield). LCMS (Method A): Rt 0.78 minutes; m/z 454 (MH+).

The synthetic route of 497-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; ALDER, Catherine Mary; BALDWIN, Ian Robert; BARTON, Nicholas Paul; CAMPBELL, Amanda Jennifer; CHAMPIGNY, Aurelie Cecile; HARLING, John David; MAXWELL, Aoife Caitriona; SIMPSON, Juliet Kay; SMITH, Ian Edward David; TAME, Christopher John; WILSON, Caroline; WOOLVEN, James Michael; WO2011/110575; (2011); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

452339-73-0, (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of (5R)-5-(2, 2-dimethyl-4H-1, 3-benzodioxin-6-yl)-1, 3-oxazolidin-2-one (Example 1 viii) (503mg) in DMF (10mL) was treated with sodium hydride (60% dispersion in mineral oil) (97mg) under nitrogen for 20 min. A solution of 1-[2-(benzyloxy) ethoxy] -4- (2-bromoethyl) benzene (676mg) in DMF (5 mL) was added and the reaction stirred for a further 2 h. The reaction mixture was concentrated in vacuo then the residue was prified by chromatography (Biotage, 40g) eluting with EtOAc-petroleum ether (2: 3) to give the title compound (585mg). LCMS RT = 3.66 min

452339-73-0, 452339-73-0 (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one 10933894, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2003/91204; (2003); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

95530-58-8,95530-58-8, (R)-4-Isopropyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of (R)-4-isopropyl-oxazolidin-2-one (1.3g, 10 mmol) and NaH (480 mg, 60% oildispersion, 12 mmol) in THF (50 ml) was stirred at rt for 2h. then cooled to 0C. A solution ofbromoacetonitrile (1.4 ml, 20 mmol) in THF (30 ml) was added slowly to the reaction mixture. Theresulting mixture was stirred at rt for overnight. The mixture was treated with small amount of waterand then the mixture was passed through a silica pad. The filtrate was concentrated and the residue20 was subjected to a short column to give the crude product. The process was repeated and bothcrude product were combined and further purified by another short column to give the product(3.3g).To a solution of above product (3.3g, 19 mmol) in THF (40 ml) at ooc was added a solution ofBH3THF in THF (1M, 200 ml). The resulting mixture was stirred at ooc for 30 min. then at rt for 4h.25 The mixture was then cooled to ooc again and treated with cold HCI (6 N, 20 ml) to strong acidic pH.The organic solvent was removed under reduced pressure. The residue was treated with NaOH (4 N,-40 ml) to pH>10, then extracted with EtOAc (5 x 80 ml) and DCM (5 x 80 ml). The combined extracts from both solvent were dried (Na2S04) and concentrated. EtOAc concentrate afford 1.9 gdesired product (not clean) and 650 mg of cleaner product was obtained from the DCM concentrate.A mixture of above product (1.9 g, 11 mmol), 3-bromo-6-fluoro-imidazo[1,2-b]pyridazine (650mg, 3 mmol), and triethylamine (1.5 ml) in isopropyl alcohol (8 ml) was heated in a microwave at5 140C for 20 min. twice. The reaction mixture was concentrated and the residue was subjected toISCO (40 g column), to gave the titled compound (345 mg). LRMS (ESI) mjz 368 and 370.2 [(M+H)]+,calc’d for C14H1sBrN502: 368.24.B

As the paragraph descriping shows that 95530-58-8 is playing an increasingly important role.

Reference£º
Patent; LEXICON PHARMACEUTICALS, INC.; BI, Yingzhi; CARSON, Kenneth Gordon; CIANCHETTA, Giovanni; GREEN, Michael Alan; KUMI, Godwin; LIANG, Zhi; LIU, Ying Jade; MAIN, Alan; ZHANG, Yulian; ZIPP, Glenn Gregory; WO2013/134219; (2013); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

80-65-9, 3-Aminooxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

80-65-9, General procedure: Following the addition of 4-(4-fluorophenoxy) butyric acid (0.71 g, 3.6 mmol) to 20 mL ofdichloromethane in a 50 mL three-necked round-bottom flask, thesolution was agitated until dissolution. Subsequently, EDCI (0.85 g,4.44 mmol) HOBt (0.6 g, 4.44 mmol) and triethylamine (0.84 g,9.25 mmol) were added in turn at 0 C. Stirring in an ice bath for 1 h,3-amino-2-oxazolidinone (0.37 g, 3.6 mmol) was added again. Thesolutionwas brought to 25 C and stirred overnight. Following TLC,the product was filtered by vacuum and dried under rotary evaporation.The product was a white solid weighing 0.51 g with a yieldof 50.2%.

80-65-9 3-Aminooxazolidin-2-one 65725, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Article; Jiang, Kai; Yan, Xinlin; Yu, Jiahao; Xiao, Zijian; Wu, Hao; Zhao, Meihua; Yue, Yuandong; Zhou, Xiaoping; Xiao, Junhai; Lin, Feng; European Journal of Medicinal Chemistry; vol. 194; (2020);,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

95530-58-8, (R)-4-Isopropyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,95530-58-8

To a solution of (R) -4-isopropyloxazolidin-2-one (25.0g, 0.194mol, 1.0eq) in anhydrous THF (1150 mL) was added n-BuLi (85.0 mL, 0.213mol, 1.1eq) at -78 under N2and the mixture was stirred at the same temperature for 1 h, a large number of white solids formed. Then propionyl chloride (20.0 mL, 0.232mol, 1.2eq) was added at -78 and the mixture was stirred at the same temperature for 1 h. After the consumption of (S) -4-isopropyloxazolidin-2-one monitored by TLC, the solution was poured into saturated ammonium chloride solution (1.2 L) and the mixture was extracted with EA (700 mL, 350 mL ¡Á 2) . The organic extract was washed with 1.0 N NaOH solution (1.0 L) and brine (1.0 L) , dried over anhydrous sodium sulfate, filtered, concentrated in vacuo and purified by SiO2column chromatography (PE : EA = 10: 1) to give the title compound as a colorless oil (32.6 g, 90.8%) . ESI m/z: calcd for C9H17NO3[M+H]+: 186.1, found 186.1.1H NMR (400 MHz, CDCl3) delta 4.48 -4.37 (m, 1H) , 4.27 (t, J = 8.7 Hz, 1H) , 4.21 (dd, J = 9.1, 3.1 Hz, 1H) , 3.04 -2.82 (m, 2H) , 2.45 -2.30 (m, 1H) , 1.17 (t, J = 7.4 Hz, 3H) , 0.90 (dd, J = 17.1, 7.0 Hz, 6H) .

95530-58-8 (R)-4-Isopropyloxazolidin-2-one 641505, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; HANGZHOU DAC BIOTECH CO. LTD; ZHAO, Robert Yongxin; YANG, Qingliang; HUANG, Yuanyuan; ZHAO, Linyao; GAI, Shun; YE, Hangbo; LEI, Jun; XU, Yifang; CAO, Mingjun; GUO, Huihui; JIA, Junxiang; TONG, Qianqian; LI, Wenjun; ZHOU, Xiaomai; XIE, Hongsheng; BAI, Lu; CAI, Xiang; ZHUO, Xiaotao; ZHANG, Xiuzheng; ZHENG, Jun; (424 pag.)WO2019/127607; (2019); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem