95715-86-9, Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
95715-86-9, To a cooled (-78 C) solution of (S)-2,2-dimethyl-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester 4-methyl ester (2 g, 7.7 mmol) in dry toluene (20 mL) in a Schlenk flask was added dropwise 1 M standard solution of diisobutylaluminum hydride in toluene (13.3 mL). The reaction mixture was stirred for 2 h at -78 C. Then the reaction was quenched by adding slowly methanol (5 mL) cooled to -78 C. The resulting white emulsion was slowly poured into ice-cold 1 M HCl (100 mL) and extracted with ethyl acetate (3 x 50 mL). The combined extracts were washed with brine (2 x 50 mL) and water (50 mL), dried over Na2SO4 and concentrated in vacuo. The crude product was purified by column chromatography (hexane – ethyl acetate v/v 9 : 1) and 1.5 g (85%) of a colorless oil was isolated. 1H and 13C NMR spectra were consistent with literature data.5 IR (ATR, cm-1) nu: 3018, 2978, 1697, 1368, 1168, 1095; 1H NMR (400 MHz, CDCl3, rotamers) delta: 9.61 (d, J = 0.8 Hz, 0.4H, CHO), 9.55 (d, J = 2.4 Hz, 0.6H, CHO), 4.34 (m, 0.4H, CH-N), 4.19 (m, 0.6H, CH-N), 4.08 (m, 2H, CH2-O), 1.65 (s, 1.7H), 1.60 (s, 1.3H), 1.56 (s, 2H), 1.51 (s, 4.5H), 1.43 (s, 5.5H) 13C NMR (100 MHz, CDCl3, minor rotamer marked with *) delta: 199.4, 152.6*, 151.3, 95.1, 94.3*, 81.4*, 81.1, 64.7, 63.9, 63.4*, 28.3, 26.7*, 25.8, 24.7*, 23.8; MS (ESI) m/z: [M+Na]+ 252.
95715-86-9 Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate 688220, aoxazolidine compound, is more and more widely used in various fields.
Reference£º
Article; Hryniewicka, Agnieszka; ?otowski, Zenon; Seroka, Barbara; Witkowski, Stanis?aw; Morzycki, Jacek W.; Tetrahedron; vol. 74; 38; (2018); p. 5392 – 5398;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem