Simple exploration of 95715-86-9

95715-86-9 Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate 688220, aoxazolidine compound, is more and more widely used in various fields.

95715-86-9, Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

95715-86-9, To a cooled (-78 C) solution of (S)-2,2-dimethyl-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester 4-methyl ester (2 g, 7.7 mmol) in dry toluene (20 mL) in a Schlenk flask was added dropwise 1 M standard solution of diisobutylaluminum hydride in toluene (13.3 mL). The reaction mixture was stirred for 2 h at -78 C. Then the reaction was quenched by adding slowly methanol (5 mL) cooled to -78 C. The resulting white emulsion was slowly poured into ice-cold 1 M HCl (100 mL) and extracted with ethyl acetate (3 x 50 mL). The combined extracts were washed with brine (2 x 50 mL) and water (50 mL), dried over Na2SO4 and concentrated in vacuo. The crude product was purified by column chromatography (hexane – ethyl acetate v/v 9 : 1) and 1.5 g (85%) of a colorless oil was isolated. 1H and 13C NMR spectra were consistent with literature data.5 IR (ATR, cm-1) nu: 3018, 2978, 1697, 1368, 1168, 1095; 1H NMR (400 MHz, CDCl3, rotamers) delta: 9.61 (d, J = 0.8 Hz, 0.4H, CHO), 9.55 (d, J = 2.4 Hz, 0.6H, CHO), 4.34 (m, 0.4H, CH-N), 4.19 (m, 0.6H, CH-N), 4.08 (m, 2H, CH2-O), 1.65 (s, 1.7H), 1.60 (s, 1.3H), 1.56 (s, 2H), 1.51 (s, 4.5H), 1.43 (s, 5.5H) 13C NMR (100 MHz, CDCl3, minor rotamer marked with *) delta: 199.4, 152.6*, 151.3, 95.1, 94.3*, 81.4*, 81.1, 64.7, 63.9, 63.4*, 28.3, 26.7*, 25.8, 24.7*, 23.8; MS (ESI) m/z: [M+Na]+ 252.

95715-86-9 Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate 688220, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Article; Hryniewicka, Agnieszka; ?otowski, Zenon; Seroka, Barbara; Witkowski, Stanis?aw; Morzycki, Jacek W.; Tetrahedron; vol. 74; 38; (2018); p. 5392 – 5398;,
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Brief introduction of 108149-63-9

108149-63-9, The synthetic route of 108149-63-9 has been constantly updated, and we look forward to future research findings.

108149-63-9, (R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound 35 (4 g, 18 mmol), intermediate 2 (4.8 g, 21.7 mmol) and triphenylphosphine (7.0 g, 27 mmol) in DCM (80mL) was added diisopropylazodicarboxylate (5.4 g, 27 mmol). The reaction mixture was stirred at RT for 3 h. Water was added and the product was extracted with DCM. Purification by flash column chromatography gave compound 36 (5.8 g, 73%).

108149-63-9, The synthetic route of 108149-63-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; EXELIXIS, INC.; XU, Wei; (170 pag.)WO2017/4609; (2017); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

 

New learning discoveries about 108149-63-9

108149-63-9, As the paragraph descriping shows that 108149-63-9 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108149-63-9,(R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of 6 (0.100 g, 0.433 mmol), appropriate substituted phenol (0.649 mmol) and PPh3 (0.182 g,0.693 mmol) in anhydrous toluene (5 mL) was added DIAD(0.14 mL, 0.693 mmol) at 80 C. After 3 h, EtOAc (40 mL)was added to the resulting solution. The organic layer was washed with 0.5 M aqueous NaOH (40 mL) and water (2 X40 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash silica gel column chromatography eluting with Hexanes/EtOAc (9:1) or (95:5) to afford compounds 7a-s.

108149-63-9, As the paragraph descriping shows that 108149-63-9 is playing an increasingly important role.

Reference£º
Article; Andrade, Saulo F.; Campos, Edmar F.S.; Teixeira, Claudia S.; Bandeira, Cristiano C.; Lavorato, Stefania N.; Romeiro, Nelilma C.; Bertollo, Caryne M.; Oliveira, Monica C.; Souza-Fagundes, Elaine M.; Alves, Ricardo J.; Medicinal Chemistry; vol. 10; 6; (2014); p. 609 – 618;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

 

Analyzing the synthesis route of 108149-63-9

The synthetic route of 108149-63-9 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108149-63-9,(R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate,as a common compound, the synthetic route is as follows.

Compound 1-150 TFA salt (60.0 mg, 0.121 mmol) and compound 1-17 (84.0 mg, 0.363 mmol) were dissolved in dry THF (3.0 mL) in a 100 mL rbf under N2. The flask was cooled in an ice/water bath for 5 min. KHMDS (0.5 in toluene, 0.97 mL, 0.49 mmol) was added dropwise. The resulting rxn soln was stirred at 0C for 2 h then slowly warmed to RT in 1.5 h and continued to stir at RT for 1 h. The mixture was cooled to 0C again and quenched with slow addition of sat’d NH4C1 aq soln (4.5 mL). The mixture was diluted with EtOAc (50 mL) and sat’d NaHC03 aq soln (5 mL). The layers were separated and the organic layer was further washed with water (1 mL). The organic layer was then dried over anhydrous sodium sulfate, filtered, and concentrated. The resulting crude pdt was purified by normal phase flash chromatography using 0-10% MeOH/DCM as the gradient to afford compound 1-18., 108149-63-9

The synthetic route of 108149-63-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; EXELIXIS, INC.; XU, Wei; (170 pag.)WO2017/4609; (2017); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

 

Some tips on 13590-42-6

13590-42-6, 13590-42-6 (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate 11736783, aoxazolidine compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13590-42-6,(S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate,as a common compound, the synthetic route is as follows.

3 g (12 mmol) beta -benzyl-L-aspartate N-carboxyanhydride (BLA-NCA) was dissolved in 20 mL of DMF and (MW = 269.51 g / mol, 0.3 g, 1.2 mmol) in a 50 mL CH 2 Cl 2 mixture and polymerized at 40 C starting from the terminal primary amine group of the octadecylamine. The reaction mixture was stirred for 2 days. The reaction mixture was rotary evaporated under high vacuum to remove the CH2CI2. 20 mL of 0.1 N HCl was slowly added to precipitate the polymer, followed by centrifugation (3000 rpm) for 5 minutes. The supernatant was discarded and the remaining residue was lyophilized to remove residual water. PH-sensitive octadecylamine-p (API-Asp) 10 was synthesized by aminolysis of the octadecylamine-PBLA octadecylamine-PBLA using 1- (3-aminopropyl) imidazole. Octadecylamine-p (API-Asp) 10 (0.2, 74.8 mumol) was dissolved in 5 mL of DMSO, and after reaction and API (1 g, 7.9 mmol) in 25 under nitrogen it was stirred for 12 hours. The reaction mixture was added dropwise to 20 mL of 1 N cold HCl aqueous solution and dialyzed against 0.01 N HCl solution three times (Spectra / Por; MWCO: 1,000 Da). The final solution was lyophilized to give octadecylamine-p (API-Asp) 10 as a white solid was obtained.

13590-42-6, 13590-42-6 (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate 11736783, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; Seoul National University Industry-Academic Cooperation Foundation; National Cancer Centre Singapore PTE; Institute For Basic Science; Hyun, Taek Hwan; Huii, Kam Man; Lung, Dae Sun; Jia, Hong Ping; (32 pag.)KR2016/105146; (2016); A;,
Oxazolidine – Wikipedia
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New learning discoveries about 2346-26-1

2346-26-1, As the paragraph descriping shows that 2346-26-1 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2346-26-1,Oxazolidine-2,4-dione,as a common compound, the synthetic route is as follows.

A mixture of (2E)-3- [5- (4-fluorophenyl)-l-methyl-lH- PYRAZOL-4-YL]-N- [4- (HYDROXYMETHYL) phenyl] acrylamide (8.4 g), thionyl chloride (2.59 mL) and tetrahydrofuran (70 mL) was heated under reflux for 3 hrs. The reaction mixture was poured into saturated aqueous sodium hydrogen carbonate, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and then saturated brine, dried (MGSO4) and concentrated to give a solid (6.22 g). To a mixture of 1, 3-oxazolidine-2,4-dione (123.3 mg) and N, N- dimethylformamide (5 mL) was added sodium hydride (60% in oil, 48.8 mg) and the mixture was stirred at room temperature for 30 min. The obtained solid (300 mg) was added to the reaction mixture and the mixture was further stirred overnight at room temperature. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed successively with 0. 1N hydrochloric acid, water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated. The residue was recrystallized from ethyl acetate-hexane to give (2E)-N-14- [ (2, 4-DIOXO-1, 3-oxazolidin-3- yl) METHYL] PHENYL}-3- [5- (4-FLUOROPHENYL)-1-METHYL-LH-PYRAZOL-4- yl] acrylamide as yellow prism crystals (132 mg, yield 37%). melting point: 239-240C.

2346-26-1, As the paragraph descriping shows that 2346-26-1 is playing an increasingly important role.

Reference£º
Patent; TAKEDA CHEMICAL INDUSTRIES, LTD.; WO2004/39365; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

 

Brief introduction of 108149-63-9

108149-63-9, The synthetic route of 108149-63-9 has been constantly updated, and we look forward to future research findings.

108149-63-9, (R)-tert-Butyl 4-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of 6 (0.100 g, 0.433 mmol), appropriate substituted phenol (0.649 mmol) and PPh3 (0.182 g,0.693 mmol) in anhydrous toluene (5 mL) was added DIAD(0.14 mL, 0.693 mmol) at 80 C. After 3 h, EtOAc (40 mL)was added to the resulting solution. The organic layer was washed with 0.5 M aqueous NaOH (40 mL) and water (2 X40 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash silica gel column chromatography eluting with Hexanes/EtOAc (9:1) or (95:5) to afford compounds 7a-s.

108149-63-9, The synthetic route of 108149-63-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Andrade, Saulo F.; Campos, Edmar F.S.; Teixeira, Claudia S.; Bandeira, Cristiano C.; Lavorato, Stefania N.; Romeiro, Nelilma C.; Bertollo, Caryne M.; Oliveira, Monica C.; Souza-Fagundes, Elaine M.; Alves, Ricardo J.; Medicinal Chemistry; vol. 10; 6; (2014); p. 609 – 618;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

 

Downstream synthetic route of 95715-86-9

As the paragraph descriping shows that 95715-86-9 is playing an increasingly important role.

95715-86-9, Methyl (R)-N-Boc-2,2-dimethyloxazolidine-4-carboxylate is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

95715-86-9, 4-Hydroxymethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (12b); A 250-ml two-necked flask was equipped with a magnetic stirring bar, reflux condenser bearing a drying tube and a dropping funnel. The flask was charged with tetrahydrofuran (100 ml) and lithium aluminium hydride (2.16 g, 57.0 mmol). While the suspension in the flask was stirred, a solution of the ester 12a (9.90 g, 38.2 mmol) in THF (50 ml) was added dropwise during 20 min. The reaction was monitored by thin layer chromatography. When the reaction was finished, the mixture was cooled in an ice bath and a solution of 10% potassium hydroxide (20 ml) was added dropwise during 10 min. The mixture was stirred for 2 h at room temperature, whereafter the white precipitate was removed by filtration through celite. The combined organic filtrates were washed with 100 ml of aqueous phosphate buffer (pH 7), and the aqueous layer was extracted with ether. The combined organic phases were dried and concentrated which gave the title compound (8.3 g, 94%). The residue was used without further purification.

As the paragraph descriping shows that 95715-86-9 is playing an increasingly important role.

Reference£º
Patent; MEDIVIR AB; WO2008/107365; (2008); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

 

Some tips on 131685-53-5

131685-53-5 (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone 10966403, aoxazolidine compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.131685-53-5,(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone,as a common compound, the synthetic route is as follows.

To a stirred solution of (S)-4-benzyl-3-propionyl oxazolidin-2-one (30 g, 128.755 mmol) in THF (50 mL), sodium bis(trimethylsilyl)amide (128.7 mL, 128.755 mmol, 1M in THF) was added slowly at -78 C and the mixture was stirred at that temperature for 2h. A solution of 3-iodo-l-propane (64.89 g, 386.265 mmol) was added to the reaction mixture at -78 C and it was stirred for additionally 2h. On completion, the reaction mixture was quenched with saturated NH4CI and extracted twice with EtOAc (2 x 200 mL) . The combined organic layers were washed with brine (200 mL), dried over anhydrous sodium sulfate, concentrated and the resulting residue was purified by silica gel column chromatography (0-10% EtOAc in pet ether as elute) to afford the title compound as colorless liquid.1H NMR (400MHz, CDCl3) delta = 7.36 – 7.30 (m, 2H), 7.30 – 7.27 (m, 1H), 7.24 – 7.19 (m, 2H), 5.83 (tdd, J = 7.2, 10.0, 17.1 Hz, 1H), 5.17 – 5.00 (m, 2H), 4.75 – 4.61 (m, 1H), 4.28 – 4.07 (m, 2H), 3.94 – 3.80 (m, 1H), 3.29 (dd, J = 3.4, 13.2 Hz, 1H), 2.70 (dd, J = 10.0, 13.5 Hz, 1H), 2.53 (td, J = 6.7, 13.9 Hz, 1H), 2.24 (td, J = 7.0, 13.8 Hz, 1H), 1.19 (d, J = 6.8 Hz, 3H).LCMS: 84% (M + H) 274., 131685-53-5

131685-53-5 (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone 10966403, aoxazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; LEO PHARMA A/S; LIANG, Xifu; LARSEN, Jens; (179 pag.)WO2018/108231; (2018); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

 

Brief introduction of 875444-08-9

The synthetic route of 875444-08-9 has been constantly updated, and we look forward to future research findings.

875444-08-9,875444-08-9, (4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4- methyloxazolidin-2-one (46g, 147mol), obtained in step 2, in DMF (150ml) was dropwise added NaHMDS (sodium hexamethyldisilazide) (176 ml, 176 mol) at -40C. The reaction mixture was stirred for 30 min, and slowly added with drops of a dilution of 2-chloro-5- (trifluoromethyl)pyridin-3-yl-methane chloride, obtained in step 1 , in DMF (30ml). The resulting reaction mixture was heated to room temperature, stirred for 3 hrs, diluted with ethyl acetate (200 ml), and added with water (500 ml) to terminate the reaction. The organic layer thus formed was withdrawn, washed with water (2.5 I), and filtered through silica-selite pad at a reduced pressure to afford the title compound (60g, 67%). 1 H NMR (400MHz, CDCI3) . 8.64 (s, 1 H), 8.01 (s, 1 H), 7.90 (s, 1 H), 7.82 (s, 2H), 5.76 (d, J = 8.0Hz, 1 H), 4.84 (d, J = 16.0Hz, 1 H), 4.47 (d, J = 16.4Hz, 1 H), 4.22 (m, 1 H), 083 (d, 3H).

The synthetic route of 875444-08-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DONG-A ST CO.,LTD; PARK, Jang Hyun; SONG, Seung Hyun; CHUNG, Han Kook; KIM, Heung Jae; LEE, Ji Hye; JANG, Byeong Jun; KIM, Eun Jung; JUNG, Hae Hum; RYU, Chae Lim; HWANG, Jae-Sung; LEE, Hyung Ki; KANG, Kyung Koo; KIM, Soon Hoe; WO2014/157994; (2014); A1;,
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