875444-08-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.875444-08-9,(4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one,as a common compound, the synthetic route is as follows.
Oxazolidinone 9 (81 mg, 0.257 mmol) was placed in a 5 mL vial, which was purged with nitrogen, and then dissolved in DMF (900 mu, 849.60 mg). The solution was cooled to -20C. NaHMDS (129 mu, 0.257 mmol) was added slowly to maintain the reaction temperature at less than -15C. The mixture was aged for 5 minutes, and then the pyridyl chloride 8 (90 mg, 0.257 mmol) was added as a solution in DMF (900 mu). The reaction was warmed to room temperature slowly. The reaction was complete after 2h at ambient temperature. The reaction was quenched with MTBE and water. The layers were separated. The organic layer was washed with water, then dried with MgSC^, and the solvent was removed by evaporation. Compound 10 (150 mg) was obtained, which could be used directly in the next step.
As the paragraph descriping shows that 875444-08-9 is playing an increasingly important role.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; THOMPSON, Christopher, F.; SWEIS, Ramzi, F.; WO2011/28395; (2011); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem