Day: September 8, 2020

497-25-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.497-25-6,Oxazolidin-2-one,as a common compound, the synthetic route is as follows.

Synthesis of (IR, 2R) and (IS, 2S)-methyl-3-(2-(4-chlorophenyl)-5′-fluoro-2- isopropyl-2′-oxospiro[cyclopropane-l,3′-indoline]-l’-yl)-5-(2-oxooxazolidin-3- yl)benzoate3-bromo-5-((l S,2S)-2-(4-chlorophenyl)-5′-fluoro-2-isopropyl-2′-oxospiro[cyclopropane- 1 , 3 ‘-indoline] – 1 ‘-yl)benzoate, 3 -bromo-5 -(( 1 R,2R)-2-(4-chlorophenyl)-5 ‘-fluoro-2- isopropyl-2′-oxospiro[cyclopropane-l,3′-indoline]-l’-yl)benzoate (0.545 g, 1 mmol), 2- oxazolidone (0.105 g, 1.2 mmol), Cul (20 mg), and K2C03 (0.276 g, 2 mmol) were placed in a Schlenk tube under Argon atmosphere and dissolved in dry acetonitrile. The N, N’- dimethyl- 1,2-ehtanediamine (21 L, 20%equiv) was added into the mixture. The mixture was strirred at 80 C for 14 hours. The solvent was removed in vacuo and the residue was purified by flash column chromatography to give the title compound as white powder (0.40 g, 73%). LC/MS m/e calcd. for C3oH26ClFN205: 548, observed (M+H)+: 549.5

The synthetic route of 497-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; CHEN, Li; HUANG, Mengwei; FENG, Lichun; HE, Yun; YUN, Hongying; WO2011/69298; (2011); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80-65-9,3-Aminooxazolidin-2-one,as a common compound, the synthetic route is as follows.,80-65-9

Example 8; Preparation of Compound 35; N-(4-chloro-2-propionylphenyl)-trifluoromethanesulfonamide (2.50 g, 7.9 mmol) and 3-amino-2-oxazolidinone (1.225 g, 11.85 mmol) were mixed in toluene (30 mL). The reaction was heated, with a Dean-Stark apparatus to remove water, at reflux for 3 hrs. The reaction mixture was cooled and evaporated to dryness. The residue was purified on a silica column using 20-100% CH2Cl2/PE, followed by 2% MeOH/DCM as solvent. The product was then recrystallized from DCM/PE to give 2.20 g of white solid. M.p. 115-117 C. 1H n.m.r. (CDCl3) delta 11.82, 1H, b; 7.69, 1H, d, J8.9 Hz; 7.60, 1H, d, J2.2 Hz; 7.42, 1H, dd, J18.9 Hz, J22.3 Hz; 4.54, 2H, t, J7.4 Hz; 3.96, 2H, t, J7.4 Hz; 2.93, 2H, q, J7.6 Hz; 1.13, 3H, t, J7.6 Hz.

The synthetic route of 80-65-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Winzenberg, Kevin Norman; Meyer, Adam Gerhard; Yang, Qi; Riches, Andrew Geoffrey; US2007/238700; (2007); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.497-25-6,Oxazolidin-2-one,as a common compound, the synthetic route is as follows.,497-25-6

A 48 mL pressure vessel containing 2-bromo-4-fluorobenzonitrile (1.00 g, 5.00 mmol), 2-oxazolidone (0.390 g, 4.50 mmol), K2CO3 (0.970 g, 7.0 mmol) and xantphos (0.231 g, 0.40 mmol) in dioxane (10 mL) was degassed with argon for 15 min. Pd2dba3 (0.140 g, 0.15 mmol) was introduced and then the reaction mixture was heated at 70 C. for 18 h. The mixture was cooled, diluted with dioxane, and then filtered through Celite. The resulting mixture was concentrated in vacuo and subjected to column chromatography on silica gel with hexanes:ethyl acetate (1:1) to (3:7) gradient as the eluent to afford the title compound as a white solid (0.460 g, 50% yield): 1H NMR (400 MHz, CDCl3) delta ppm: 7.73 (1H, dd, J=5.8, 8.6 Hz), 7.43 (1H, dd, J=2.5, 9.6 Hz), 7.11 (1H, ddd, J=2.5, 7.5, 8.7Hz), 4.60 (2H, t, J=7.1 Hz), 4.29 (2H, t, J=7.1 HJz); LCMS (+ESI, M+H+) m/z 207.

The synthetic route of 497-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bristol-Myers Squibb Company; US2007/111984; (2007); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.695-53-4,5,5-Dimethyloxazolidine-2,4-dione,as a common compound, the synthetic route is as follows.

695-53-4, To a solution of 7-(3-ethyl-heptyl)-6-(4-formyl-phenoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-2- carbonitrile (720 mg, 1.90 MMOL) in MeOH (30 ml) and THF (30 ml) is added portionwise NaBH4 (100 mg, 2.60 MMOL). The reaction mixture is stirred at rt for 4 h, and the bulk of solvents are removed in vacuo. The residue is diluted with water, and extracted with CH2CI2. The combined organic extracts are washed with brine, and dried over NA2S04, filtered, and concentrated in vacuo. The residue is purified by silica gel column chromatography to give the alcohol 7-(3-ethyl-heptyl)-6-(4-hydroxy-methyl-phenoxymethyl)-7h-pyrrolo[2,3- d]pyrimidine-2-carbonitrile. To a solution of said, alcohol (140 mg, 0.36 MMOL), 5,5-dimethyl-oxazolidinedione (46 mg, 360 MMOL), and Ph3P (105 mg, 0.40 MMOL) in THF (2 mL) is added DEAD (0.25 ml, 0.46 MMOL). The reaction mixture is stirred at rt for overnight. After concentration, the residue is purified by RP-HPLC to give the title compound; Rf 0. 38 (n- Hexane: EtOAc=1: 1) ;H-HMR (400 MHz) 0.92-1. 00 (m, 2H), 1. 18-1. 25 (m, 3H), 1. 30-1. 40 (m, 1H), 1. 58 (s, 6H), 1. 68-1. 78 (m, 7H), 4.35-4. 39 (m, 2H), 4.62 (s, 2H), 5.22 (s, 2H), 6. 71 (s, 1H), 6. 95 (dd, 2H), 7.37 (dd, 2H), 8. 96 (s, 1H).

The synthetic route of 695-53-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/69256; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

80-65-9, 3-Aminooxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,80-65-9

[Example 1] 4-fluoro-N-(2-oxo-oxazolidin-3-yl)benzamide (Compound 1) 0.5g (4.9mmol) 3-amino oxazolidinone was put in a 25ml three-necked flask, 10ml water was added, and 0.92g (5.9mmol) 4-fluorobenzoyl chloride was added slowly dropwise at room temperature, the reactiong system was stirred overnight. White precipitate was precipitated, filtrated under vacuum, and recrystallized in ethanol to get white solid (Compound 1) 0.61g, with a yield of 56%. 1H-NMR(400MHz,DMSO)deltappm:10.87(1H,s),7.97(2H,t,J=4.0Hz,J=4.0Hz),7.40 (2H,t,J=8.0Hz,J=12.0Hz),4.46(2H,t,J=8.0Hz,J=8.0Hz), 3.79(2H,t,J=8.0Hz,J=8.0Hz); EI-MS(m/z):225.1[M+H]+; m.p.189-192C.

80-65-9 3-Aminooxazolidin-2-one 65725, aoxazolidine compound, is more and more widely used in various.

Reference£º
Patent; Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China; LI, Song; XIAO, Junhai; ZHAO, Mingming; ZHONG, Wu; WANG, Lili; ZHENG, Zhibing; XIE, Yunde; LI, Xingzhou; ZHAO, Guoming; ZHOU, Xinbo; WANG, Xiaokui; CHEN, Wei; EP2952509; (2015); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

95530-58-8,95530-58-8, (R)-4-Isopropyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The R type EvansAuxiliary base addedTo 250 ml of dry reaction flask,70 ml of anhydrous THF dissolved,Cooled to -78 C,And then slowly adding n-BuLi (18.5 ml, 46.3 mmol)After 30 min reaction,(E) -2-methyl-2-butenoyl chloride (5.0 g, 42.5 mmol) was added and reacted for 30 min. The temperature was raised to 0 C and the reaction was continued for 15 min.20ml saturated ammonium chloride quenching reaction, separationThe organic phase was extracted with ethyl acetate (20 ml x 3). The organic phases were combined, washed with saturated brine (40 ml), dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure.The residue was subjected to column chromatography (elution conditions, petroleum ether: ethyl acetate = 10: 1) to give the product as a white solid, 7.7 g, 94% yield;

The synthetic route of 95530-58-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Fudan University; Lei Xinsheng; Lin Guoqiang; Zhao Qun; Xu Qianqian; Shan Guangsheng; (20 pag.)CN104418707; (2017); B;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.139009-66-8,(S)-N-Boc-2,2-dimethyloxazolidine-4-carboxylic Acid,as a common compound, the synthetic route is as follows.

6.2 Synthesis of tert-butyl (4S)-2,2-dimethyl-4-(morpholin-4-ylcarbonyl)- 1,3- oxazolidine-3-carboxylate a62.; 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (740 mg, 3.86 mmol, 1.1 eq) and 1-hydroxybenzotriazole hydrate (522 mg, 3.86 mmol, 1.1 eq) are added to a cold solution (00C) of (4S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1 ,3-oxazolidine-4-carboxylic acid a61 (860 mg, 3.50 mmol, 1 eq) and morpholine (336 mul, 3.86 mmol, 1.1 eq) in N1N- dimethylformamide (30 ml). The mixture is stirred at room temperature for 6 hours and concentrated to dryness. The residue is dissolved in a 0.5 N aqueous solution of hydrochloric acid and extracted three times with dichloromethane. The combined organic phases are washed with a saturated solution of sodium hydrogenocarbonate, dried over magnesium sulfate and concentrated under vacuum to afford 991 mg of tert-butyl (4S)-2,2- dimethyl-4-(morpholin-4-ylcarbonyl)-1 ,3-oxazolidine-3-carboxylate a62 as a yellow solid. Yield: 90 %. LC-MS (MH+): 315., 139009-66-8

The synthetic route of 139009-66-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UCB PHARMA S.A.; WO2008/128919; (2008); A2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.452339-73-0,(R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.,452339-73-0

Sodium hydride (60% oil dispersion, 1.26 g) was added to a stirred, cooled (ice-bath) solution of (5R)-5- (4H-1, 3-benzodioxin-6-yl)-2-oxazolidinone (5.47 g) in dry DMF (50 ML) under nitrogen and the mixture was stirred for 15 min at 5 C. A solution of 6-bromohexyl 4- (3-IODOPHENYL) BUTYL ether (10.7 g) in DMF (30 ml) was then added dropwise over 10 min. The mixture was stirred for 2 h at ambient temperature, then poured into aqueous solution of ammonium chloride and extracted into ethyl acetate. The combined extracts were washed with water, dried (NA2SO4) and evaporated. The residue was purified on a biotage cartridge (90 g) eluting with ether-hexane (3: 2) to give the title compound (9.8 g). LCMS RT= 4.20 min.

452339-73-0 (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one 10933894, aoxazolidine compound, is more and more widely used in various.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/39762; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80-65-9,3-Aminooxazolidin-2-one,as a common compound, the synthetic route is as follows.,80-65-9

0.5g (4.9mmol) 3-amino oxazolidinone was put in a 25 ml three-necked flask, 10ml 1,2-dimethoxyethane was added, and 1.2g (5.9mmol) n-butyl isocyanate was slowly added dropwise, and then after 30 mins, white solid was precipitated, and the mixture was heated under refluxing for 15 mins, filtrated under vacuum, and recrystallized in isopropanol, to get 0.61g white solid (Compound 15), with a yield of 62%. 1H-NMR(400MHz,DMSO)deltappm:8.01(1H,s),6.69(1H,s),4.30(2H,t,J=8.0Hz,J=8.0Hz ),3.59(2H,t,J=8.0Hz,J=8.0Hz),3.00(2H,m),1.37(2H,m),1.25(2H,m),0.87(3H,m);EI-MS( m/z): 202.2[M+H]+; m.p. 98-100C.

As the paragraph descriping shows that 80-65-9 is playing an increasingly important role.

Reference£º
Patent; Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China; LI, Song; XIAO, Junhai; ZHAO, Mingming; ZHONG, Wu; WANG, Lili; ZHENG, Zhibing; XIE, Yunde; LI, Xingzhou; ZHAO, Guoming; ZHOU, Xinbo; WANG, Xiaokui; CHEN, Wei; EP2952509; (2015); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

497-25-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.497-25-6,Oxazolidin-2-one,as a common compound, the synthetic route is as follows.

General procedure: In a two-neck round-bottom flask equipped with a stir-bar, CuCl2 (0.2 equiv), oxazolidin-2-one (5.0 equiv), Na2CO3 or Cs2CO3 (2.0 equiv) and molecular sieve (4) were combined. The reaction flask was purged with oxygen for 15 min. A solution of pyridine (2.0 equiv) in dry toluene (0.2 M) was added to the reaction flask via a syringe at room temperature. Two balloons filled with oxygen were connected to the reaction flask via a needle. The flask was placed in an oil-bath and heated to 70 C. A solution of alkyne (1.0 equiv) in dry toluene was added over 4 h using a syringe pump. After the addition was completed, the reaction mixture was stirred at 70 C for 8 h and then cooled to room temperature. The crude mixture was concentrated under vacuum and the residue was purified by flash chromatography on silica gel.

The synthetic route of 497-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lingua, Hugo; Vibert, Francois; Mouysset, Dominique; Siri, Didier; Bertrand, Michele P.; Feray, Laurence; Tetrahedron; vol. 73; 25; (2017); p. 3415 – 3422;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem