With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.147959-19-1,(S)-tert-Butyl 2,2-dimethyl-4-(2-oxoethyl)oxazolidine-3-carboxylate,as a common compound, the synthetic route is as follows.
n-BuLi (2 M in hexane, 1.7 mL, 3.45 mmol, 1.5 eqv.) was added to a stirred suspension of methyltriphenylphosphonium bromide (1.23 g, 3.45 mmol, 1.5 eqv.) in dry THF (10 mL) under argon at 0 C dropwise over 5 min, and the resulting solution was allowed to stir for 20 min at 0 C. A solution of the aldehyde 4 (560 mg, 2.30 mmol) in THF (5 mL) was then added dropwise over 5 min with stirring at the same temperature. After 20 min, the solution was allowed to come to room temperature and stirred for another 4 h. The reaction mixture was quenched by addition of aq NH4Cl solution (3 mL) and then extracted with ethyl acetate (2 x 50 mL). The combined organic extract was washed successively with H2O (40 mL) and brine solution (40 mL) and then dried over MgSO4. It was then filtered, and the filtrate was concentrated under reduced pressure to leave the crude product which was purified by column chromatography over silica gel (EtOAc-PE, 1:19) to give the olefin 1b as a colourless liquid (410 mg, 74 %)., 147959-19-1
147959-19-1 (S)-tert-Butyl 2,2-dimethyl-4-(2-oxoethyl)oxazolidine-3-carboxylate 10586317, aoxazolidine compound, is more and more widely used in various.
Reference£º
Article; Chattopadhyay, Shital K.; Kundu, Indranil; Synthetic Communications; vol. 44; 14; (2014); p. 2112 – 2120;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem