Day: September 1, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.452339-73-0,(R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.,452339-73-0

A solution of (5R)-5- (2, 2-dimethyl-4H-1, 3-benzodioxin-6-yl)-1, 3-oxazolidin-2-one (EXAMPLE 1VI) (500mg) in DMF (15ML) under nitrogen at 0 was treated with sodium hydride (60% dispersion in mineral oil, 96mg) and the mixture stirred at 20 for 10 min. A SOLUTION OF 6-BROMOHEXYL 4-PENTYN-1-YL ether (WO 02/066422) (545mg) in DMF (1 ML) was added and the mixture stirred at 20 for 18 h. Phosphate buffer solution (pH 6. 5) and water were added and the mixture was extracted with EtOAc. The extract was washed with water and dried (NA2SO4). Solvent EVAPORATION IN VACUO gave a residue, which was purified by flash chromatography on silica gel. Elution with EtOAc-PE (2: 3) gave the title compound (700mg). LCMS RT = 3.48min.

As the paragraph descriping shows that 452339-73-0 is playing an increasingly important role.

Reference£º
Patent; GLAXO WELLCOME HOUSE; WO2004/37773; (2004); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

2346-26-1, Oxazolidine-2,4-dione is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 35 A mixture of 4-[4-[2-(1,3-dioxolan-2-yl) ethyl]phenoxyacetyl]-5-methyl-2-phenyloxazole (1.8 g), 2,4-oxazolidinedione (0.925 g), piperidine (0.12 g) and acetic acid (30 ml) was heated for 15 hours under reflux. The reaction mixture was concentrated under reduced pressure. To the concentrate was added a saturated aqueous solution of sodium hydrogencarbonate, followed by extraction with chloroform. The chloroform layer was washed with water, dried (MgSO4), followed by distilling off the solvent. The oily residue was subjected to a silica gel column chromatography. From the fractions eluted with methanol-chloroform (1:30, v/v) was obtained 5-[3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)-2-oxoethoxy]phenyl]propylidene]-2,4-oxazolidinedione. This compound was dissolved in tetrahydrofuran (THF) (30 ml), to which was added palladium-carbon (5%, 0.3 g).

2346-26-1, As the paragraph descriping shows that 2346-26-1 is playing an increasingly important role.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; US5665748; (1997); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.131685-53-5,(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone,as a common compound, the synthetic route is as follows.

131685-53-5, A solution of oxazolidinone (+)-1a (1.79 g, 7.67 mmol) in degassed CH2CI2 (30 mL, 4 A MS dried, argon sparged) was cooled to 0 C and n-Bu2BOTf (1.0 M in hexane, 7.67 mL) was introduced, followed by addition of NiPr2Et (1.34 mL, 8.05 mmol). The mixture was cooled to-78 C. A precooled (- 78 C, degassed solution of aldehyde (+) -1 (2.2 g, 6.66 mmol) in CH2CI2 (8 mL) was then added via cannula over 0.25 h (2 mL rinse). After an additional 1.0 h at-78 C, the reaction was warmed to-0 C, stirred for 1 h, then quenched with pH 7 potassium phosphate monobasic-sodium hydroxide buffer (0.05 M, 5.5 mL). A solution of 30% H2O2 in MeOH (1: 2,17 mL) was added to the vigorously stirred reaction mixture at such a rate as to maintain an internal temp < 8 C (15 min, 0'C cooling bath). The reaction was stirred 1 h at room temperature, and the resulting layers were separated. The aqueous layer was extracted (3 x CH2CI2), and the combined organic layers were washed with saturated aqueous NaHCO3 (15 mL), water (15 mL) and saturated brine (2 x 10 mL). The organic layer was dried over MgS04, filtered, and concentrated in vacuo. Flash chromatography (20% ethyl acetate/hexanes) provided (+)-2 (3. 4 9, 85%) as a white foam. [a] 2D +17. 0 (c = 1, CHCI3) ; IR (NaCI) 3523,3081, 3052,2971, 2925, 2872, 1780,1699, 1489,1447, 1157,1099, 1070 ; 1H NMR (500 MHz, CDCI3) 8 7.48 (m, 6H), 7.37-7. 29 (m, 8H), 7.28-7. 20 (m, 6H), 4.67 (dddd, J = 8.9, 5.6, 5.2, 3.7 Hz, 1H), 4.17 (d, J = 5.2 Hz, 2H), 4.04 (ddd, J = 5.9, 4.8, 3.3 Hz, 1H), 3.92 (dddd, J = 6.7, 6.7, 6.7, 6.7 Hz, 1H), 3.25 (dd, J = 13.4, 3.4 Hz, 1H), 3.23 (dd, J= 9.3, 5.6 Hz, 1H), 3.17 (dd, J= 9.3, 5.2 Hz, 1H), 2.96 (d, J= 3.35 Hz, 1H), 2.78 (dd, J= 13.4, 9.7 Hz, 1H), 1.89 (m, 1H), 1.32 (d, J = 6. 7 Hz, 3H), 1.09 (d, J = 6. 7 Hz, 3H) ; 13C NMR (125 MHz, CDCI3) 6 176.8, 152.6, 143.9, 135.1, 129.4, 128.9, 128.6, 127.8, 127.4, 126.9, 86.9, 73.8, 67.0, 66.0, 55.1, 40.8, 37.7, 36.5, 13.2, 12.2 ; high resolution mass spectrum (ES+) m/z 586.2561, [ (M) +, calcd for C36H37NOsNa : 586.2569]. The synthetic route of 131685-53-5 has been constantly updated, and we look forward to future research findings. Reference£º
Patent; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; WO2005/35489; (2005); A2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95530-58-8,(R)-4-Isopropyloxazolidin-2-one,as a common compound, the synthetic route is as follows.,95530-58-8

A 2.5M solution of n-butyllithium in hexanes (34.0mL, 85mmol) was added dropwise at -78C to a solution of (4R)-isopropyloxazolidinone (10.0g, 77mmol) in anhydrous THF (100mL). The mixture was stirred at -78C for 15min, and freshly distilled tiglyl chloride (9.3mL, 85mmol), prepared from tiglic acid and SOCl2, was added dropwise to the mixture. The mixture was stirred for 30minat -78C and slowly warmed up to 0C. After 15minat 0C, the mixture was quenched with a satd NH4Cl aqsolution (20mL). The organic solvents were evaporated and the mixture was extracted with AcOEt (50mL¡Á3). The combined extract was washed with brine (30mL), dried over MgSO4, concentrated, and purified by column chromatography (Petroleum ether/ethyl acetate=10:1). Compound 1 was obtained as a white solid (15.5g, 95%); mp 62-63C. Rf (Petroleum ether/ethyl acetate=10:1) 0.40. [alpha]D20 -91.2 (c 0.13, CHCl3). [lit.:20 its enantiomer, mp 63-64C. [alpha]D30 +91.8 (c 0.07, CHCl3)]. 1H NMR (400MHz, CDCl3) delta 6.21 (q, J=6.8Hz, 1H), 4.58-4.46 (m, 1H), 4.32 (dd, J=8.9, 8.9Hz, 1H), 4.17 (dd, J=8.9, 5.6Hz, 1H), 2.42-2.28 (m, 1H), 1.91 (s, 3H), 1.81 (d, J=8.9Hz, 3H), 0.92 (d, J=7.1Hz, 3H), 0.91 (d, J=6.6Hz, 3H). ESI-MS: Calcdfor C11H18NO3+ [M+H]: 212.1, found:

As the paragraph descriping shows that 95530-58-8 is playing an increasingly important role.

Reference£º
Article; Xu, Qian-Qian; Zhao, Qun; Shan, Guang-Sheng; Yang, Xi-Cheng; Shi, Qi-Yuan; Lei, Xinsheng; Tetrahedron; vol. 69; 50; (2013); p. 10739 – 10746;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

875444-08-9, (4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

875444-08-9, A solution of (45,5J?)-5-[3;5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one (12.00 g, 38.3 mmol) in THF (200 mL) was cooled to 0 C. NaH (0.919 g, 38.3 mmol) was added. The mixture was stirred at 0 C for 30 min. The title compound from Step A (10.0 g, 31.9 mmol) in THF (30 mL) was added. The mixture was stirred at 0 C and then room temperature for 4 h. Saturated NH C1 (10 mL) was added. The mixture was extracted with ethyl acetate (3 xlOO mL). The combined organic fractions were washed with brine (saturated, 20 mL), dried (Na2S0 ), filtered and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography on silica gel Biotage 65i, eluting with EtOAc/hexane (20/80) to give the title compound as a colorless solid. NMR (CDCl3s 500 MHz) delta 8.57 (s, 1H), 7.94 (s, 1H), 7.82 (s, 2H), 5.86 (d, J= 8.5 Hz, 1H), 4.97 (d, J- 18.0 Hz, 1H), 4.46 (m5 1H), 4.28 (d, J= 17.5 Hz, 1H), 2.60 (s, 3H), 0.83 (d, J= 6.5 Hz 3H)

As the paragraph descriping shows that 875444-08-9 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; LU, Zhijian; CHEN, Yi-Heng; SMITH, Cameron; LI, Hong; THOMPSON, Christopher, F.; SWEIS, Ramzi; SINCLAIR, Peter; KALLASHI, Florida; HUNT, Julianne; ADAMSON, Samantha, E.; DONG, Guizhen; ONDEYKA, Debra, L.; QIAN, Xiaoxia; SUN, Wanying; VACHAL, Petr; ZHAO, Kake; WO2012/58187; (2012); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

184363-66-4, (S)-4-Phenyl-3-propionyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To the reaction flask was added 150 mL of a 1 M solution of LiHMDS (lithium bis(trimethylsilyl)amide) in tetrahydrofuran. Cool to -50 C. Slowly drip the tetrahydrofuran containing 32.8 g (0.15 mol, 1.1 eq) of (S)-4-phenyl-3-propionyloxazolidinone(60mL) solution,The mixture was further stirred at -50 C for 80 minutes.Dropping 50 g (0.134 mol, 1.0 eq) containing compound IIb Anhydrous tetrahydrofuran (100 mL) solution,Continue to incubate for 30 minutes after the dropwise addition.Slowly warm to room temperature and stir. Complete to the substrateConversion.Wash the organic layer with saturated ammonium chloride solution (100ml), water (100ml), saturated brine (100ml), separate, organicThe layer was dried over anhydrous MgSO4 and evaporated.53.2 g of crude compound IIIb were obtained, The yield was 87.3%., 184363-66-4

The synthetic route of 184363-66-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shanghai Disainuo Chemical Pharmaceutical Co., Ltd.; Yancheng Disainuo Pharmaceutical Co., Ltd.; Jiangsu Puxin Pharmaceutical Co., Ltd.; Shanghai Disainuo Pharmaceutical Co., Ltd.; Li Jinliang; Zhao Nan; Lou Yanpeng; (12 pag.)CN109206419; (2019); A;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

169048-83-3, (S)-5-(Chloromethyl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(S)-6(21.7 mg, 160 mumol) in N,N-dimethylformamide (DMF)(4.0 mL) was added to a solution of 4 (43.5 mg, 123 mumol).K2CO3 (204 mg, 1.48 mmol) was added, and the reactionmixture was stirred at 140C for 45 min. The mixture wasfiltered, and the filtrate was diluted with H2O (5 mL) and thenextracted with CHCl3 (3¡Á30 mL). The combined extract waswashed with brine (20 mL), dried, and concentrated in vacuoto give a residue (60 mg). Chromatography on a silica gel columnwith n-hexane-EtOAc (1 : 2-1 : 1) as the eluent gave (S)-1(26.8 mg, 48%) as a colorless powder. 1H-NMR (400 MHz,CDCl3) delta: 7.35 (2H, s), 5.79 (1H, br), 5.02 (1H, ddt, J=8.7, 6.2,5.0 Hz), 4.82 (1H, br), 4.20 (2H, d, J=5.0 Hz), 3.91 (1H, dd,J=8.7, 6.2 Hz), 3.82 (1H, t, J=8.7 Hz), 3.67 (3H, s), 3.39 (2H, q,J=6.7 Hz), 2.74 (2H, t, J=6.7 Hz). HR-FAB-MS m/z 450.9498[M+H]+ (Calcd for C14H17Br2N2O5: 450.9504). [alpha]D25 +21.4(c=0.1, MeOH).

169048-83-3, As the paragraph descriping shows that 169048-83-3 is playing an increasingly important role.

Reference£º
Article; Sirimangkalakitti, Nachanun; Yokoya, Masashi; Chamni, Supakarn; Chanvorachote, Pithi; Plubrukrn, Anuchit; Saito, Naoki; Suwanborirux, Khanit; Chemical and Pharmaceutical Bulletin; vol. 64; 3; (2016); p. 258 – 262;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2346-26-1,Oxazolidine-2,4-dione,as a common compound, the synthetic route is as follows.

A solution of 3.1 g (11.1 mmol) of 1-[(4-bromobutyl)oxy]naphthalene (Eur. J. Med. Chem. 1997, 32, 175-179) and 1.35 g (13.3 mmol) of 1,3-oxazolidine-2,4-dione (J. Med. Chem. 1991, 34, 1542-1543) in 30 ml of tetrahydrofuran is admixed dropwise with a solution of 2.55 g (22.2 mmol) of 1,1,3,3-tetramethylguanidine in 15 ml of tetrahydrofuran. The mixture is heated at reflux for 8 hours. 0.28 g (2.7 mmol) of 1,3-oxazolidine-2,4-dione and 0.32 g (2.7 mmol) of 1,1,3,3-tetramethylguanidine are added and the mixture is heated at reflux for 4 more hours. The reaction mixture is cooled using an ice bath, and 100 ml of ethyl acetate and then 50 ml of 1M aqueous hydrochloric acid are added. The system is decanted and the aqueous phase is extracted with 2*80 ml of ethyl acetate. The organic phases are subsequently washed with 80 ml of water and then with 80 ml of saturated aqueous sodium chloride solution. They are dried over sodium sulfate and then evaporated to dryness. The product is purified by chromatography on silica gel, eluding with an 80/20 mixture of cyclohexane and ethyl acetate, to give 2.0 g of product, which is used as it is in the following step.

2346-26-1, 2346-26-1 Oxazolidine-2,4-dione 97389, aoxazolidine compound, is more and more widely used in various.

Reference£º
Patent; SANOFI-AVENTIS; US2007/21424; (2007); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.152305-23-2,(S)-4-(4-Aminobenzyl)oxazolidin-2-one,as a common compound, the synthetic route is as follows.

Sodium nitrite (16 gm) in water (120 ml) was added slowly for a period of 30 minutes at 0 deg C to a solution of (S)-4-(4-Aminobenzyl)-2-oxazolidinone (40 gm), concentrated hydrochloric acid (46 ml) and water (480 ml) in round bottomed flask, cooled to 0 deg C and stirred for 1 hour. The above diazotized solution was added for a period of 30 minutes at 0 deg C to sodium sulfite (78.3 gm) in water (200 ml) in another round bottomed flask, cooled to 0 deg C, slowly allowed to room temperature, heated to 55 deg C and stirred for 15 minutes at 60 deg C. Added concentrated hydrochloric acid (80 ml) to the reaction mass, stirred for 16 hours at 60 deg C, nitrogen gas was applied and heated to 90 deg C. Water (80 ml) was added to the reaction mass for 15 minutes at 90 deg C, added 4-(dimethylamino)-butyraldehyde diethylacetal for a period of 40 minutes, heated to reflux, stirred for 3 hours at reflux, cooled to 25 – 30 deg C and the pH was adjusted to 7 by adding sodium hydroxide solution(30percent, 230 ml). Extracted with ethyl acetate (7 X 200 ml), adjusted the pH of the aqueous layer to 10 by adding sodium hydroxide solution (30percent, 100 ml), heated to 50 deg C and again extracted with ethyl acetate (8 X 200 ml) at 50 deg C. Both the organic layers were combined, dried with sodium sulfate, given carbon treatment and the solvent was distilled off completely under vacuum at 50 – 55 deg C, ethyl acetate (80 ml) was added to the reaction mass at 25 deg C, stirred for 1 hour and cooled to 10 deg C. Stirred for 30 minutes at 10 deg C, filtered the material and washed with chilled ethylacetate(20 ml) under nitrogen atmosphere and dried at 45 -50 deg C to yield 40 gm of (4S)-4-[[3-[2-(Dimethylamino)ethyl]~ 1 H-indol-5-yl]methyl]-2-oxazolidinone.(4S)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone (40 gm, Zolmitriptan) was dissolved in isopropanol (200 ml) at 25 deg C, heated to reflux, stirred for 40 minutes at reflux and slowly allowed to cool to 0 deg C. Stirred the reaction mass for 1 hour at 0 deg C, filtered the compound, washed with chilled isopropanol(40 ml) and dried at 40 – 45 deg C under vacuum to yield (4S)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone isopropanol solvate (32 gm, Zolmitriptan isopropanol solvate; HPLC purity. 99.32percent). Zolmitriptan isopropanol solvate obtained above (32 gm) was dissolved in isopropyl acetate (2250 ml) at 25 deg C. Then the contents were heated to reflux and maintained for 30 minutes to form clear solution. The solution was cooled to 25 deg C during a period of 1 hour. The separated solid was filtered, washed with isopropyl acetate (160 ml) to obtain 32 gm of zolmitriptan isopropyl acetate solvate (HPLC purity: 99.8percent)., 152305-23-2

As the paragraph descriping shows that 152305-23-2 is playing an increasingly important role.

Reference£º
Patent; HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; RAJI REDDY, Rapolu; MURALIDHARA REDDY, Dasari; SRINIVASA RAO, Thungathurthy; WO2010/73256; (2010); A2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem

95530-58-8, (R)-4-Isopropyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,95530-58-8

The R-type Evans cofactor was added to a 250 ml dry reaction flask and dissolved in 70 ml of dry THF. The solution was cooled to -78 C and n-BuLi (18.5 ml, 46.3 mmol) was added slowly. After 30 min, (E) -2-methyl-2-butyryl chloride (5.0 g, 42.5 mmol) was added and the reaction was allowed to proceed for 30 min and the temperature was raised to 0 C. (20 ml of X3). The combined organic layers were washed with saturated brine (40 ml), dried over anhydrous sulfuric acid (20 ml) and concentrated in vacuo. The organic layer was extracted with ethyl acetate,Dried and filtered. The filtrate was concentrated under reduced pressure and the residue was subjected to column chromatography (elution conditions, petroleum ether: ethyl acetate = 10: 1) to give the product as a white solid (yield: 94%).

95530-58-8 (R)-4-Isopropyloxazolidin-2-one 641505, aoxazolidine compound, is more and more widely used in various.

Reference£º
Patent; Fudan University; Lei, Xinsheng; Lin, Guojiang; Xu, Qianqian; Zhao, Qun; (29 pag.)CN104341276; (2016); B;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem